Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC23210.15690/vramn.v67i12.477IMMUNOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ИММУНОЛОГИИMECHANISMS OF ANTIBIOFILM IMMUNITYМЕХАНИЗМЫ АНТИБИОПЛЕНОЧНОГО ИММУНИТЕТАChebotar'I. V.ЧеботарьИ. В.
Russian Federation

Candidate of Medical Sciences, Associate Professor, Chair of Microbiology and Immunology, State Education Institute Nizhniy Novgorod State Medical Academy, Ministry of Health, Russian Federation Address: 603005, Nizhniy Novgorod, Minin and Pozharskiy square, 10/1; Tel.: (831) 439-09-43

rector@gma.nnov.ruNizhny Novgorod State Medical AcademyНижегородская государственная медицинская академия, Российская Федерация101220126712Вестник Российской академии медицинских наук222907082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/232

The formation of microbial biomembranes complicates clinical course of infectious diseases. The review deals with the problem of interaction between immune system and specific components of microbial biofilms. The immune mechanisms which may destroy biomembranes and damage biomembrane-associated microorganisms are analyzed. The vulnerable spots of immune defense against microbal biomembranes are described. This review also issues future prospects of immune-based control of microbal biomembrane processes.

Образование микробных биопленок осложняет течение инфекционного процесса. Обзор посвящен проблеме взаимодействия иммунной системы человека с элементами, специфичными для микробных биопленок. Проанализированы иммунные механизмы, которые могут приводить к отторжению биопленок и повреждению биопленочных микробов. Описаны уязвимые места в иммунной обороне макроорганизма от биопленок. Обсуждаются перспективы использования знаний об антибиопленочных рекциях иммунитета в процессах управления биопленочным процессом.

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