Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC22710.15690/vramn.v68i1.540SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯPROTEOMICS AS A FUNDAMENTAL TOOL FOR SUBCLINICAL SCREENING, TESTS VERIFICATION AND ASSESSMENT OF APPLIED THERAPYПРОТЕОМИКА КАК ФУНДАМЕНТАЛЬНЫЙ ИНСТРУМЕНТ ДОКЛИНИЧЕСКОГО СКРИНИНГА, ВЕРИФИКАЦИИ АНАЛИЗОВ И ОЦЕНКИ ПРИМЕНЯЕМОЙ ТЕРАПИИSuchkovS. V.СучковС. В.
Russian Federation

PhD, Professor of Department of A.I. Evdokimov Clinical Immunology, Professor of Department of Pathology I.M. Sechenov First Moscow State Medical University Address: 101000, Moscow, Miasnitskaya St., 20; tel.: (495) 771-32-32; fax: (495) 708-31-56

ssuchkov57@gmail.comKostushevD. S.ГнатенкоД. А.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (425) 037-08-54

dkostushev@gmail.comKrynskiiS. A.КостюшевД. С.
Russian Federation

First Moscow State Medical University Student Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (425) 037-08-54

dkostushev@gmail.comGnatenkoD. A.КрынскийС. А.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University Address: 119991, Moscow, Trubetskaya St., 8/2

gnatenkodmitrii@gmail.comPal'tsevM. A.ПальцевМ. А.
Russian Federation

PhD, the Academician of the Russian Academy of Medical Sciences, Professor, Deputy Director for Science of Research Center «Kurchatov Institute» Address: 123182, Moscow, Academician Kurchatov Square, 1; tel.: (499) 196-95-39; fax: (499) 196-17- 04; e-mail: paltsev_ma@rrcki.ru

paltsev_ma@rrcki.ruI.M. Sechenov First Moscow State Medical University, Russian Federation A.I. Evdokimov Moscow State Medical Dental University, Russian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация Московский государственный медико-стоматологический университет им. А.И. Евдокимова, Российская ФедерацияA.I. Evdokimov Moscow State Medical Stomatological University Moscow, Russian FederationМосковский государственный медико-стоматологический университет им. А.И. Евдокимова, Российская ФедерацияI.M. Sechenov First Moscow State Medical University, Russian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская ФедерацияNational Research Centre «Kurchatov Institute», Moscow, Russian FederationРНЦ «Курчатовский институт», Москва, Российская Федерация22012013681Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук657107082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/227

Proteomics is a science which studies proteins of the body, interactions of proteins and their biological functions. Today, it is an essential partner in establishing preclinical diagnosis protocols. In conjunction with other sciences such as genomics and bioinformatics it will be possible to diagnose diseases on the earliest stages before its clinical onset or to gain the dynamics of pathological processes in the body and response to drug therapy. This article discusses general aspects of proteomics as well as special ones on the basis of models of cardiac diseases and cancer.

Протеомика ― наука, изучающая белки живых организмов, их функции и взаимодействие, на сегодняшний день является незаменимым компонентом в создании протоколов доклинической диагностики. В сочетании с достижениями геномики, биоинформатики, использование технологий протеомики ― мощный инструмент ранней диагностики заболеваний, а также динамической оценки протекания патологических процессов (в частности, на фоне проводимой фармакотерапии). В статье рассмотрены общие и частные аспекты протеомики, основанные на базе моделей кардио- и онкозаболеваний.

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