Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC22610.15690/vramn.v68i1.539SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯINTRODUCTION INTO PPPM: EXPERIENCE OF THE PAST AND TOMORROW’S REALITYВВЕДЕНИЕ В ПРЕДИКТИВНО-ПРЕВЕНТИВНУЮ МЕДИЦИНУ: ОПЫТ ПРОШЛОГО И РЕАЛИИ ДНЯ ЗАВТРАШНЕГОBodrovaT. A.БодроваТ. А.
Russian Federation

Master of Science, Researcher of National Research University «Higher School of Economics» Address: 101000, Moscow, Myasnitskaya St., 20, tel.: (495) 771-32-32, fax: (495) 628-79-31

tatianabodrova@gmail.comKostushevD. S.КостюшевД. С.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University. Address: 119991, Moscow, Trubetskaya St., 8/2

dkostushev@gmail.comAntonovaE. N.АнтоноваЕ. Н.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University. Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (495) 609-67-00

dkostushev@gmail.comGnatenkoD. A.ГнатенкоД. А.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University.Address: 119991, Moscow, Trubetskaya St., 8/2

gnatenkodmitrij@gmail.comBocharovaM. O.БочароваМ. О.
Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University. Address: 119991, Moscow, Trubetskaya St., 8/2

maria.bocciarova@gmail.comLopukhinYu. M.ЛопухинЮ. М.
Russian Federation

PhD, Academician of the Russian Academy of Medical Science, Honorary Director of Scientific Research Institute of Physical-Chemical Medicine Address: Moscow, Malaya Pirogovskaya 1a; tel.: (499) 246-45-16

yuri.lopukhin@ripcm.org.ruPal'tsevM. A.ПальцевМ. А.
Russian Federation

PhD, the Academician of the Russian Academy of Medical Sciences, Deputy Director for Medical-Biological Research, Research Center «Kurchatov Institute» Address: 123182, Moscow, Academician Kurchatov Square, 1; tel.: (499) 196-95-39

tatianabodrova@gmail.comSuchkovS. V.СучковС. В.
Russian Federation

PhD, Professor of Department of Pathology I.M. Sechenov First Moscow State Medical University, Professor of Department of A.I. Evdokimov Clinical Immunology, Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (495) 708-31-56

ssuchkov57@gmail.comNational Research University «Higher School of Economics», Moscow, Russian Federation University of World Politics and Law, The Diplomatic Academy of the Ministry of Foreign Affairs of Russian Federation, Moscow, Russian FederationНациональный исследовательский университет «Высшая школа экономики», Москва, Российская Федерация Университет мировой политики и права Дипломатической академии МИД России, Москва, Российская ФедерацияA.I. Evdokimov Moscow State Medical Stomatological University Moscow, Russian FederationМосковский государственный медико-стоматологический университет им. А.И. Евдокимова, Российская ФедерацияScientific-Research Institute of Physical Chemical Medicine Moscow, Russian FederationНаучно-исследовательский институт физико-химической медицины ФМБА РФ, Москва, Российская ФедерацияNational Research Centre «Kurchatov Institute», Moscow, Russian FederationНациональный исследовательский центр «Курчатовский институт», Москва, Российская ФедерацияI.M. Sechenov First Moscow State Medical University, Russian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация22012013681Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук586407082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/226

Health service today is on the verge of broad changes. The intensive practical application of the achievements of genomics, proteomics, metabolomics and bioinformatics has significantly deepened and continues to deepen our view of the pathological processes taking place at a level of biostructures. In the nearest future this progress will give medical practitioners the opportunity to focus on a subclinical stage of the disease, i.e. on the earliest stages of the pathological process. This will require the prediction of disease development risks, subclinical diagnostics with the precise staging of the pathological process, and, finally, the application as early as possible of targeted pharmacotherapeutic methods in order to prevent the manifestation of the disease or its progression into more severe stages. All these principles create the framework of a fundamentally new «3P» strategy in medicine: predictive, preventive and personalized medicine.

Сегодня здравоохранение стоит на пороге больших перемен. Активное внедрение достижений геномики, протеомики, метаболомики и биоинформатики в практическую деятельность существенно расширило и продолжит расширять наше представление о патологических процессах, происходящих на уровне биоструктур. Этот прогресс в скором времени даст клиницисту возможность фокусировать внимание на доклиническом этапе заболевания, т.е. на самых ранних стадиях развития патологии. Основными звеньями работы с пациентом должны стать предикция риска заболевания, доклиническая диагностика с определением стадии и как можно более раннее таргетное фармакотерапевтическое вмешательство с целью превенции развития заболевания или его перехода в более тяжелую стадию. Эти принципы легли в основу принципиально новой стратегии «трех П»: предиктивной, превентивной и персонифицированной медицины.

preventionpredictionpreclinical diagnosticsgenomicsproteomicsmetabolomicsbioinformaticsпревенцияпредикциядоклиническая диагностикабиомаркерыгеномикапротеомикаметаболомикабиоинформатика1. Ray R. The future of medicine. Am. J. Med. 2012; 125 (3): 236–239.2. Jones T, Price P. Development and experimental medicine applications of PET in oncology: a historical perspective. Lancet Oncol. 2012 Mar;13(3); 116–125.3. Patel N.R., McPhail M.J., Shariff M.I., Keun H.C., Taylor-Robinson S.D. Biofluid metabonomics using (1)H NMR spectroscopy: the road to biomarker discovery in gastroenterology and hepatology. Exp. Rev. Gastroenterol. Hepatol. 2012 Apr;6(2); 239–251.4. Henderson J. Health economics and Policy. Cincinnati, Ohio: South-Western College publishing. 1999. P. 1–30, 290–321, 378–414.5. Hood L., Balling R., Auffray C. Revolutionizing medicine in the 21(st) century through systems approaches. Biotechnol. J. 2012; 002/biot.2011003066. Tran B., Dancey J.E., Kamel-Reid S., McPherson J.D., Bedard P.L., Brown A.M., Zhang T., Shaw P., Onetto N., Stein L., Hudson T.J., Neel B.G., Siu L.L. Cancer genomics: technology, discovery, and translation. J. Clin. Oncol. 2012; 30 (6): 647–660.7. Hagmann H., Thadhani R., Benzing T., Karumanchi S.A., Stepan H. The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Clin. Chem. 2012; 58 (5): 837–845.8. Moons K.G., Kengne A.P., Woodward M., Royston P., Vergouwe Y., Altman D.G., Grobbee D.E. Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker. Heart. 2012; 98 (9): 683–690.9. Moons K.G., Kengne A.P., Grobbee D.E., Royston P., Vergouwe Y., Altman D.G., Woodward M. Risk prediction models: II. External validation, model updating, and impact assessment. Heart. 2012; 98 (9): 691–698.10. Saubermann A.J., Lagasse R.S. Prediction of rate and severity of adverse perioperative outcomes: «normal accidents» revisited. Mt. Sinai J. Med. 2012; 79 (1): 46–55. doi: 10.1002/msj.21295.11. Farra N., Manickaraj A.K., Ellis J., Mital S. Personalized medicine in the genomics era: highlights from an international symposium on childhood heart disease. Future Cardiol. 2012; 8 (2): 157–160.12. Suchkov S.V., Martynov L.A,, Vinokurov I.A., Kostyushe D.S., Andreeva A.A., Gadzhieva S.I., Gnatenko D.A., Shonfild I., Lopukhin Yu.M., Notkins A., Pal'tsev M.A. On the prospects of preclinical diagnosis within the objectives of preventive and preventive and predictive medicine. Efferentnaya i fiziko-khimicheskaya meditsina – Efferent and physico-chemical medicine. 2010; 63–74.13. Maeng J.H., Lee B.C., Ko Y.J., Cho W., Ahn Y., Cho N.G., Lee S.H., Hwang S.Y. A novel microfluidic biosensor based on an electrical detection system for alpha-fetoprotein. Biosens Bioelectron. 2008; 23 (9): 1319–1325. Epub 2007 Dec 5.14. Stewart S.E., Yu D., Scharf J.M., Neale B.M., Fagerness J.A., Mathews C.A., Arnold P.D., Evans P.D., Gamazon E.R., Osiecki L., McGrath L., Haddad S., Crane J., Hezel D., Illman C., Mayerfeld C., Konkashbaev A., Liu C., Pluzhnikov A., Tikhomirov A., Edlund C.K., Rauch S.L., Moessner R., Falkai P., Maier W., Ruhrmann S., Grabe H.J., Lennertz L., Wagner M., Bellodi L., Cavallini M.C., Richter M.A., Cook E.H. Jr., Kennedy J.L., Rosenberg D., Stein D.J., Hemmings S.M., Lochner C., Azzam A., Chavira D.A., Fournier E., Garrido H., Sheppard B., Umaña P., Murphy D.L., Wendland J.R., Veenstra-Vanderweele J., Denys D., Blom R., Deforce D., Van Nieuwerburgh F., Westenberg H.G., Walitza S., Egberts K., Renner T., Miguel E.C., Cappi C., Hounie A.G., Conceição do Rosário M., Sampaio A.S., Vallada H., Nicolini H., Lanzagorta N., Camarena B., Delorme R., Leboyer M., Pato C.N., Pato M.T., Voyiaziakis E., Heutink P., Cath D.C., Posthuma D., Smit J.H., Samuels J., Bienvenu O.J., Cullen B., Fyer A.J., Grados M.A., Greenberg B.D., McCracken J.T., Riddle M.A., Wang Y., Coric V., Leckman J.F., Bloch M., Pittenger C., Eapen V., Black D.W., Ophoff R.A., Strengman E., Cusi D., Turiel M., Frau F., Macciardi F., Gibbs J.R., Cookson M.R., Singleton A., Hardy J., Crenshaw A.T., Parkin M.A., Mirel D.B., Conti D.V., Purcell S., Nestadt G., Hanna G.L., Jenike M.A., Knowles J.A., Cox N., Pauls D.L. Genome-wide association study of obsessive-compulsive disorder. Mol. Psychiatry. 2012; doi: 10.1038/mp.2012.85.15. Pal'tsev M.A., Cherepakhina N.E., Shoenfeld Y., Shogenov Z.S., Tabaksoeva Zh.A., Agirov M.M., Suchkov S.V. Post-infection clinico-immunologic syndrome: fundamentals of etiopathogenesis and immunogenodiagnostic strategy Vestn. Ross. Akad. Med. Nauk – Annals of Academy of Medical Sciences. 2009; 10: 25–31.16. Suchkov S., Kostyushev D., Gnatenko D., Gadzhieva S. and Paltsev M. Preclinical and predictive algorithms in monitoring patients with autoimmune diseases and their relatives-at-risk. Autoimmune disorders ― current concepts and advances from bedside to mmechanistic insights. Fang-Ping Huang (ed.). 2011. ISBN: 978-953-307-653-9, InTech17. Kostyushev D., Tsarev I., Gnatenko D., Paltsev M., Suchkov S. Myelin-associated serological targets as applicable to diagnostic tools to be used at the preclinical and transient stages of multiple sclerosis progression. Open J. Immunol. 2011; 1 (3): 80–86. doi:10.4236/oji.2011.13010 Copyright18. Kelloff G.J., Sigman C.C. Cancer biomarkers: selecting the right drug for the right patient. Nat. Rev. Drug Discov. 2012; 11 (3): 201–214.19. Robinton D.A., Daley G.Q. The promise of induced pluripotent stem cells in research and therapy. Nature. 2012; 481 (7381): 295–305.20. Sheiman I., Shishkin S. New challenges and new objectives problems of economic transition. Russian Health Care. 2010; 52 (12): 4–49.21. Pozgar, George D. Legal aspects of health care administration. 10th ed. NY, 2007. Chapter 21.