Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC225910.15690/vramn2259OBSTETRICS AND GYNAECOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ АКУШЕРСТВА И ГИНЕКОЛОГИИReview ArticleImmune Landscape Characteristics in EndometriosisХарактеристика иммунного ландшафта при эндометриозеhttps://orcid.org/0000-0003-4620-39226460-1758PatsapOlga I.ПацапОльга Игоревна
Russian Federation

МD, PhD

к.м.н.

Cleosnake@yandex.ruhttps://orcid.org/0000-0003-3526-0366KhabarovaMarina B.ХабароваМарина Борисовна
Russian Federation

МD, PhD

к.м.н.

khabarovaMB@yandex.ru57218589485AGU-7781-20225725-7792BuyanovaAnastasiia A.БуяноваАнастасия Александровна
Russian Federation

Laboratory Assistant

лаборант

anastasiiabuianova97@gmail.comhttps://orcid.org/0000-0002-4822-09568105-7908MikhalevSergey A.МихалевСергей Александрович
Russian Federation

МD, PhD

к.м.н.

mikhalev@me.comhttps://orcid.org/0000-0002-8347-45563830-8152AtyakshinDmitriy A.АтякшинДмитрий Андреевич
Russian Federation

МD, PhD

д.м.н.

atyakshin-da@rudn.ruhttps://orcid.org/0000-0001-5485-58033815-4541BabkinaAlexandra V.БабкинаАлександра Владимировна
Russian Federation

MD

врач-патологоанатом

nikanorovaalex@gmail.comhttps://orcid.org/0000-0003-2052-914X2086-7513MikhalevaLiudmila M.МихалеваЛюдмила Михайловна
Russian Federation

МD, PhD, Professor, Corresponding Member of the RAS

д.м.н., профессор, член-корреспондент РАН

mikhalevalm@yandex.ruPeoples’ Friendship University of RussiaРоссийский университет дружбы народовI.M. Sechenov First Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)Pirogov Russian National Research Medical UniversityРоссийский национальный исследовательский медицинский университет имени Н.И. ПироговаCity Clinical Oncological Hospital No. 1Городская клиническая онкологическая больница № 1B.V. Petrovsky Russian Scientific Center of SurgeryРоссийский научный центр хирургии имени академика Б.В. Петровского040320237815102710202203022023Copyright ©; 2023, "Paediatrician" Publishers LLCCopyright ©; 2023, Издательство "Педиатръ"2023"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/2259

This review is devoted to endometriosis-associated immune cells and immune molecules, analysis of various databases, new insights, theories, biomarkers, reviews of research in this area. To date, many attempts have been made to establish a certain role of immune cells and the microenvironment in the development of endometriosis. Nevertheless, despite intensive studies of endometriosis, the role of inflammatory cells and molecules has not yet been fully studied. As we know, the pathobiology of endometriosis is not fully understood, and its progression is associated with a local and systemic inflammatory reaction. It is important to clarify the role of the immune system to better understand its significance in the pathogenesis of endometriosis, especially in the case of atypical and endometriosis-associated ovarian tumors. The above requires further study of this problem in order to optimize the pathogenetically justified modern therapy of endometriosis.

Обзор посвящен эндометриоз-ассоциированным иммунным клеткам и иммунным молекулам, анализу различных баз данных, а также полученным новым представлениям, теориям, биомаркерам, исследованиям в этой области. До настоящего времени было предпринято много попыток определения роли иммунных клеток и микроокружения в развитии эндометриоза. Тем не менее, несмотря на интенсивные исследования эндометриоза, роль клеток и молекул воспаления освещена не в полном объеме. Сегодня достаточно поверхностно изучены патобиология эндометриоза и роль в прогрессировании заболевания местной и системной воспалительной реакции. Не уточнены роль иммунной системы и ее значение в патогенезе эндометриоза, в том числе в случаях атипичного эндометриоза и эндометриоз-ассоциированных опухолей яичников. Вышеизложенное требует дальнейшего изучения данной проблемы с целью оптимизации патогенетически обоснованной современной терапии эндометриоза.

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