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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">225</article-id><article-id pub-id-type="doi">10.15690/vramn.v68i1.538</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PHYSIOLOGY: CURRENT ISSUES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ФИЗИОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE MECHANISMS OF ADAPTATION OF THE VASCULAR BED TO HEMODYNAMIC CHANGES IN PORTAL HYPERTENSION</article-title><trans-title-group xml:lang="ru"><trans-title>МЕХАНИЗМЫ АДАПТАЦИИ СОСУДИСТОГО РУСЛА К ГЕМОДИНАМИЧЕСКИМ НАРУШЕНИЯМ ПРИ ПОРТАЛЬНОЙ ГИПЕРТЕНЗИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Garbuzenko</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Гарбузенко</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate Professor, Professor of Department of Surgery, Chelyabinsk State Medical Academy Address: 454092, Chelyabinsk, Vorovskogo St., 64; tel.: (351) 268-77-72</p></bio><email>garb@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Chelyabinsk State Medical Academy, Russian Federation</institution></aff><aff><institution xml:lang="ru">Челябинская государственная медицинская академия, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-01-22" publication-format="electronic"><day>22</day><month>01</month><year>2013</year></pub-date><volume>68</volume><issue>1</issue><issue-title xml:lang="en">Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciences</issue-title><issue-title xml:lang="ru">Вестник Российской академии медицинских наук</issue-title><fpage>52</fpage><lpage>57</lpage><history><date date-type="received" iso-8601-date="2015-08-07"><day>07</day><month>08</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, Издательство "Педиатръ"</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/225">https://vestnikramn.spr-journal.ru/jour/article/view/225</self-uri><abstract xml:lang="en"><p><italic>The data of the literature on the mechanisms of restructuring of vascular bed in response to hemodynamic changes due to portal hypertension.. Despite the fact that these changes are compensatory-adaptive reaction to the deteriorating conditions of blood circulation, they contribute to its progression, promoting the development of serious complications, one of which was bleeding from esophageal varices.</italic><italic/></p></abstract><trans-abstract xml:lang="ru"><p><italic>Представлены данные литературы о механизмах структурной перестройки сосудистого русла в ответ на гемодинамические нарушения, обусловленные портальной гипертензией. Несмотря на то, что эти изменения служат компенсаторно-приспособительной реакцией на ухудшающиеся условия кровообращения, они приводят к её прогрессированию, способствуя развитию тяжелых осложнений, одним из которых являются кровотечения из варикозно расширенных вен пищевода. </italic></p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>liver cirrhosis</kwd><kwd>portal hypertension</kwd><kwd>pathogenesis</kwd><kwd>vascular remodeling</kwd><kwd>angiogenesis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>цирроз печени</kwd><kwd>портальная гипертензия</kwd><kwd>патогенез</kwd><kwd>ремоделирование сосудов</kwd><kwd>ангиогенез</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	Garbuzenko D.V. Multiorgan hemodynamic abnormalities in liver cirrhosis. Ter. arkhiv = Therapeutic archive. 2007; 79 (2): 73–77.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2.	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