Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC222910.15690/vramn2229ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИReview ArticleSystemic Inflammatory Response as a Prognostic Factor in Breast Cancer. Part I. Tumor-Promoting Inflammation. Serum Inflammatory MarkersСистемная воспалительная реакция как фактор прогноза при раке молочной железы. Часть I. Опухоль-промотирующее воспаление. Сывороточные маркеры воспаленияhttps://orcid.org/0000-0001-7406-99737102748586I-2033-20141805-8141SergeevaNatalia S.СергееваНаталья Сергеевна
Russian Federation

PhD in Biology, Professor

д.б.н., профессор

prognoz.01@mail.ruhttps://orcid.org/0000-0002-8017-56576603382243L-3592-20184364-6134KarmakovaTatiana A.КармаковаТатьяна Анатольевна
Russian Federation

PhD in Biology

д.б.н.

kalmar123@yandex.ruhttps://orcid.org/0000-0003-3347-31061134-3930PolyakMarianna A.ПолякМарианна Александровна
Russian Federation
marianna29@yandex.ruhttps://orcid.org/0000-0002-5920-5823546833463009992-7676AlentovIgor I.АлентовИгорь Игоревич
Russian Federation

PhD in Biology

к.б.н.

igoralentov@yandex.ruhttps://orcid.org/0000-0001-8784-841566027098531759-8101KaprinAndrey D.КапринАндрей Дмитриевич
Russian Federation

MD, PhD, Professor, Academician of the Russian Academy of Medical Sciences

д.м.н., профессор, академик РАМН

kaprin@mail.ruP.A. Herzen Moscow Oncology Research InstituteМосковский научно-исследовательский онкологический институт им. П.А. ГерценаNational Medical Radiology Research CenterНациональный медицинский исследовательский центр радиологииPeoples’ Friendship University of RussiaРоссийский университет дружбы народов281220227753453530310202203112022Copyright ©; 2022, "Paediatrician" Publishers LLCCopyright ©; 2022, Издательство "Педиатръ"2022"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/2229

Chronic inflammation caused by exposure to external or internal factors increases the risk of developing malignancies and promotes tumor progression due to the influence on the key elements of carcinogenic mechanisms. At the system level signs of a chronic inflammation are manifested by an increase of inflammatory mediators and acute phase proteins levels in the blood, a change in the ratio of circulating leukocyte populations, and disturbances in the hemostasis system. This review is devoted to serum and hematological parameters of the systemic inflammatory response (SIR) in breast cancer (BC). The first part of the review outlines general concept about the role of inflammatory factors in the development of malignant tumors. It provides information on the most well studied serum inflammatory markers in breast cancer: cytokines, including interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), as well as C-reactive protein (CRP). The main properties of these polypeptides, which link them with tumor-promoting inflammation, are considered. An analysis of the data on the clinical significance of the serum level of cytokines and CRP in breast cancer accumulated to date is presented. Correlations of the elevated levels of the serum inflammatory markers with clinical and morphological characteristics of the disease, tumor response to chemotherapy, overall and relapse-free survival of patients indicate the feasibility of in-depth investigation of the issue for the purpose of the practical application of the systemic inflammatory markers as predictive and prognostic indicators in BC.

Хроническое воспаление, вызванное воздействием внешних или внутренних факторов, увеличивает риск развития злокачественных новообразований и способствует опухолевой прогрессии, оказывая промотирующее действие на ведущие патогенетические звенья канцерогенеза. Признаки хронического воспалительного процесса на системном уровне проявляются увеличением в крови содержания медиаторов воспаления и белков острой фазы, изменением соотношения популяций циркулирующих лейкоцитов, нарушениями со стороны системы гемостаза. Настоящий обзор посвящен исследованиям сывороточных и гематологических показателей системной воспалительной реакции (СВР) при раке молочной железы (РМЖ). В первой части обзора изложены общие представления о роли факторов хронического воспаления в развитии злокачественных опухолей. Представлены сведения о наиболее хорошо изученных при РМЖ сывороточных маркерах воспаления: цитокинах — интерлейкине-6 (ИЛ-6), интерлейкине-8 (ИЛ-8), факторе некроза опухолей-альфа (ФНО-α), а также С-реактивном белке (СРБ). Рассматриваются основные свойства этих полипептидов, связывающие их с механизмами опухоль-промотирующего воспаления. Приводится анализ накопленных на сегодняшний день данных о клинической значимости сывороточного уровня цитокинов и СРБ при РМЖ. Наблюдаемые корреляции выраженности системного воспалительного ответа с клинико-морфологическими характеристиками заболевания, частотой ответа на химиотерапию, общей и безрецидивной выживаемостью свидетельствуют о целесообразности углубленных исследований системных маркеров воспаления при РМЖ с целью их практического использования как дополнительных предиктивных и прогностических показателей.

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