Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC212410.15690/vramn2124CARDIOLOGY AND CARDIOVASCULAR SURGERY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИ И СЕРДЕЧНО-СОСУДИСТОЙ ХИРУРГИИReview ArticleThe Relationship between Inflammation and Hemostasis Disorders in Cardiovascular and Infectious DiseasesВзаимосвязь воспаления и нарушений гемостаза при сердечно-сосудистых и инфекционных заболеванияхhttps://orcid.org/0000-0002-5145-21841202-3719BykovVladimir V.БыковВладимир Валерьевич
Russian Federation

MD, PhD

к.м.н.

vladimir.b.1989@gmail.comhttps://orcid.org/0000-0001-5094-3742P-8522-20168818-0543VengerovskiiAleksandr I.ВенгеровскийАлександр Исаакович
Russian Federation

MD, PhD, Professor

д.м.н., профессор

pharm-sibgmu@rambler.ruhttps://orcid.org/0000-0002-3829-7132A-4208-20178645-9815UdutVladimir V.УдутВладимир Васильевич
Russian Federation

MD, PhD, Professor, Corresponding Member of the RAS

д.м.н., профессор, член-корреспондент РАН

udutv@mail.ruInnovative Pharmacological Research LLCООО «Инновационные фармакологические разработки»Siberian State Medical UniversityСибирский государственный медицинский университетGoldberg Research Institute of Pharmacology and Regenerative MedicineНаучно-исследовательский институт фармакологии и регенеративной медицины им. Е.Д. ГольдбергаTomsk National Research Medical Center of the Russian Academy of SciencesТомский национальный исследовательский медицинский центр Российской академии наук141120227742612662206202217092022Copyright ©; 2022, "Paediatrician" Publishers LLCCopyright ©; 2022, Издательство "Педиатръ"2022"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/2124

Thrombosis and inflammation develop concomitantly during inflammatory, cardiovascular and infectious diseases. Thrombosis induces inflammation and immune system disruption, while inflammation leads to increased hemostasis a vascular thrombosis. Combined use of anti-inflammatory and antithrombotic drugs often leads to adverse effects, for example, nonsteroidal anti-inflammatory drugs induce gastric ulcers, aggravated by bleeding. Vascular endothelial dysfunction plays an important role in the development of thrombosis and inflammation, therefore, research and development of drugs improving endothelial function is a promising approach to preventing thrombotic events arising from inflammation or infectious disease.

Тромбоз и воспаление взаимно активируются при воспалительных, сердечно-сосудистых и инфекционных заболеваниях. Тромбоз сопровождается развитием воспаления и изменениями иммунного ответа, при воспалении активируется гемостаз и формируются внутрисосудистые тромбы. При совместном применении противовоспалительных и антитромботических средств нередко возникают побочные эффекты, например, нестероидные противовоспалительные средства вызывают образование язв в желудке, осложненных кровотечением. В патогенезе тромбоза и воспаления большое значение имеет дисфункция сосудистого эндотелия, и разработка лекарственных средств, улучшающих функции эндотелия, представляется перспективным подходом для предотвращения тромботических событий, являющихся следствием воспаления или инфекционного заболевания.

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