Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC212210.15690/vramn2122EPIDEMIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭПИДЕМИОЛОГИИReview ArticleCOVID-19 in Russia: Evolution of Views on the Pandemic. Report IICOVID-19 в России: эволюция взглядов на пандемию. Сообщение 2https://orcid.org/0000-0002-3625-42787223-9834StarodubovVladimir I.СтародубовВладимир Иванович
Russian Federation

MD, PhD, Professor, Academician of the RAS

д.м.н., профессор, академик РАН

starodubov@mednet.ruhttps://orcid.org/0000-0002-0210-45705940-7554BeregovykhValery V.БереговыхВалерий Васильевич
Russian Federation

PhD in Technical Sciences, Professor, Academician of the RAS

д.т.н., профессор, академик РАН

beregovykh@ramn.ruhttps://orcid.org/0000-0003-4228-90444038-7455AkimkinVasily G.АкимкинВасилий Геннадьевич
Russian Federation

MD, PhD, Professor, Academician of the RAS

д.м.н., профессор, академик РАН

vgakimkin@yandex.ruhttps://orcid.org/0000-0002-6686-90118375-2270SemenenkoTatiana A.СемененкоТатьяна Анатольевна
Russian Federation

MD, PhD, Professor

д.м.н., профессор

meddy@inbox.ruhttps://orcid.org/0000-0002-1322-01558840-5814UglevaSvetlana V.УглеваСветлана Викторовна
Russian Federation

MD, PhD, Associate Professor

д.м.н., профессор

uglevas@bk.ruhttps://orcid.org/0000-0002-5999-21501645-5524AvdeevSergey N.АвдеевСергей Николаевич
Russian Federation

MD, PhD, Professor, Corresponding Member of the RAS

д.м.н., профессор, член-корреспондент РАН

serg_avdeev@list.ruhttps://orcid.org/0000-0003-3385-26326269-7990ZykovKirill A.ЗыковКирилл Алексеевич
Russian Federation

MD, PhD, Professor of the RAS

д.м.н., профессор РАН

kiriliaz@inbox.ruhttps://orcid.org/0000-0003-4871-23419733-2755TrofimovaTatiana N.ТрофимоваТатьяна Николаевна
Russian Federation

MD, PhD, Professor

д.м.н., профессор

ttrofimova@sogaz-clinic.ruhttps://orcid.org/0000-0002-4165-804X4168-6400PogosovaNana V.ПогосоваНана Вачиковна
Russian Federation

MD, PhD, Professor

д.м.н., профессор

nanapogosova@gmail.comhttps://orcid.org/0000-0001-7166-02908770-6877PerekhodovSergey N.ПереходовСергей Николаевич
Russian Federation

MD, PhD, Professor

д.м.н., профессор

persenmd@mail.ruhttps://orcid.org/0000-0002-0616-97771372-7623KuzinStanislav N.КузинСтанислав Николаевич
Russian Federation

MD, PhD, Professor

д.м.н., профессор

kuzin@cmd.suhttps://orcid.org/0000-0003-4737-941X7156-2948YacyshinaSvetlana B.ЯцышинаСветлана Борисовна
Russian Federation

PhD in Biology, Senior Research Associate

к.б.н., с.н.с.

svetlana.yatsyshina@pcr.mshttps://orcid.org/0000-0002-3503-23669852-8292PetrovVadim V.ПетровВадим Викторович
Russian Federation

head of the scientific group for the development of new molecular biological technologies

руководитель научной группы разработки новых молекулярно-биологических технологий

petrov@pcr.mshttps://orcid.org/0000-0001-5524-02969082-5749KhafizovKamil F.ХафизовКамиль Фаридович
Russian Federation

PhD in Biology

к.б.н.

khafizov@cmd.suhttps://orcid.org/0000-0003-3093-57314860-7909DubodelovDmitry V.ДубоделовДмитрий Васильевич
Russian Federation

MD, PhD

к.м.н.

dubodelov@cmd.suhttps://orcid.org/0000-0002-0121-521X9726-9380GasanovGasan A.ГасановГасан Алиевич
Russian Federation
gasanovgt500@gmail.comhttps://orcid.org/0000-0001-7524-3080SvanadzeNino Kh.СванадзеНино Хвичаевна
Russian Federation

MD

врач-эпидемиолог

svanadze@cmd.suhttps://orcid.org/0000-0001-7970-74957854-7358CherkashinaAnna S.ЧеркашинаАнна Сергеевна
Russian Federation

PhD in Chemistry

к.х.н.

cherkashina@pcr.mshttps://orcid.org/0000-0002-8813-59323156-7024SinitsynEvgeny A.СиницынЕвгений Александрович
Russian Federation

Chief Physician of the Medical Center

главный врач медицинского центра

sinymlad@list.ruhttps://orcid.org/0000-0001-9277-22915267-9598RvachevaAnna V.РвачеваАнна Валерьевна
Russian Federation

MD, PhD

к.м.н.

arvatcheva@mail.ruSergeevaNatal'ya V.СергееваНаталья Васильевна
Russian Federation

assistant of the Department of Infectious Diseases

ассистент кафедры инфекционных болезней

Tkb_3@mail.ruPolosovaTatiana A.ПолосоваТатьяна Александровна
Russian Federation

MD, PhD, Associate Professor

к.м.н., доцент

uglevas@bk.ruhttps://orcid.org/0000-0001-9577-4815ZykovaAlexandra A.ЗыковаАлександра Алексеевна
Russian Federation

MD, PhD

к.м.н.

zykova.aal@medsigroup.ruhttps://orcid.org/0000-0001-6622-47349418-3070ZeleninDmitrii A.ЗеленинДмитрий Александрович
Russian Federation

MD, PhD

к.м.н.

zelenin@68gkb.ruhttps://orcid.org/0000-0003-4678-54598064-1419GorbenkoMihail Yu.ГорбенкоМихаил Юрьевич
Russian Federation

MD, PhD

к.м.н.

gorbenko@pochta.ruhttps://orcid.org/0000-0001-9548-64268161-4082RodyukovaIrina S.РодюковаИрина Сергеевна
Russian Federation

MD, PhD, Associate Professor

к.м.н., доцент

irina.rodyukova@gmail.comhttps://orcid.org/0000-0001-5891-3417ChausNikolay I.ЧаусНиколай Иванович
Russian Federation

MD, PhD, Associate Professor

к.м.н., доцент

nikchaus@yandex.ruhttps://orcid.org/0000-0001-6053-46513059-5317SnitsarArtem V.СницарьАртем Владимирович
Russian Federation

MD

сердечно-сосудистый хирург

snitsar@68gkb.ruRussian Research Institute of HealthЦентральный научно-исследовательский институт организации и информатизации здравоохраненияI.M. Sechenov First Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingЦентральный НИИ эпидемиологииNational Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. GamaleyaНациональный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. ГамалеиPulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russian FederationНаучно-исследовательский институт пульмонологии Федерального медико-биологического агентства РоссииА.I. Yevdokimov Moscow State University of Medicine and DentistryМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваPavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет имени И.П. ПавловаNational Medical Research Center of Cardiology named after Academician E.I. ChazovНациональный медицинский исследовательский центр кардиологии имени академика Е.И. ЧазоваProfessor G.A. Zakharyin Tuberculosis Clinical Hospital No. 3Туберкулезная клиническая больница № 3 имени профессора Г.А. ЗахарьинаCity Clinical Hospital named after V.P. DemihovГородская клиническая больница имени В.П. ДемиховаPirogov Russian National Research Medical University (Pirogov Medical University)Российский научно-исследовательский институт имени Н.И. ПироговаRussian Medical Academy of Continuous Professional EducationРоссийская медицинская академия непрерывного профессионального образования141120227742913062106202217092022Copyright ©; 2022, "Paediatrician" Publishers LLCCopyright ©; 2022, Издательство "Педиатръ"2022"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/2122

Over the two years of the novel coronavirus infection (COVID-19) pandemic, there has been an evolution of views in various fields of medicine, which has led to a powerful development of scientific research in the field of epidemiology, clinic, diagnosis and therapy of COVID-19. This article discusses the evolution of views and approaches to the study of the clinic and therapy of COVID-19. The symptoms and aggravation of the course of cardiovascular diseases with COVID-19 have been established. The main strategy for organizing surgical care for patients with COVID-19 is indicated. The main criteria for the treatment of COVID-19, the need to prescribe SGCS on an individual basis, and the need to search for new methods of anti-inflammatory therapy for COVID-19, one of which may be the use of alkylating drugs in ultra-low doses, are described.

За два года пандемии новой коронавирусной инфекции (COVID-19) произошла эволюция взглядов в различных областях медицины, что привело к мощному развитию научных исследований в области эпидемиологии, клиники, диагностики и терапии COVID-19. В данной статье освещены вопросы эволюции взглядов и подходов к изучению клиники и терапии COVID-19. Установлены симптомы и утяжеление течения сердечно-сосудистых заболеваний при COVID-19. Указана основная стратегия организации хирургической помощи пациентам с COVID-19. Описаны основные критерии терапии COVID-19, необходимости назначения CГКС на индивидуальной основе и необходимости поиска новых методов противовоспалительной терапии COVID-19, одним из которых может стать применение алкилирующих препаратов в ультранизких дозах.

SARS-CoV-2COVID-19therapycardiologysurgerySARS-CoV-2COVID-19терапиякардиологияхирургическая помощьWuhan Municipal Health Commission. Report of clustering pneumonia of unknown etiology in Wuhan City. Wuhan, China: Wuhan Municipal Health Commission. Available from: http://wjw.wuhan.gov.cn/ front/web/showDetail/2019123108989 (In Chin.)COVID-19 Research and Innovation. Powering the world’s pandemic response – now and in the future. Available from: https://cdn.who.int/media/docs/default-source/blue-print/achievement-report-_grif_web_finalversion15.pdf?sfvrsn=39052c73_9&download=trueCOVID-19, MERS & SARS/NIH: National Institute of Allergy and Infectious Diseases. (n.d.). Retrieved September 6, 2020. Available from: https://www.niaid.nih.gov/diseases-conditions/covid-19Коронавирус. Available from: https://coronavirus-monitor.info/Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052–2059. doi: https://doi.org/10.1001/jama.2020.6775Xu J, Xiao W, Liang X, et al. A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity. BMC Public Health. 2021;21(1):1533. doi: https://doi.org/10.1186/s12889-021-11051-wTian W, Jiang W, Yao J. Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis. J Med Virol. 2020;92(10):1875–1883. doi: https://doi.org/10.1002/jmv.26050Бойцов С.А., Погосова Н.В., Палеев Ф.Н., и др. Клиническая картина и факторы, ассоциированные с неблагоприятными исходами у госпитализированных пациентов с новой коронавирусной инфекцией COVID-19 // Кардиология. — 2021. — Т. 61. — № 2. — С. 4–14. [Boytsov SA, Pogosova NV, Paleev FN, et al. Clinical Characteristics and Factors Associated with Poor Outcomes in Hospitalized Patients with Novel Coronavirus Infection COVID-19. Kardiologiia. 2021;61(2):4–14. (In Russ.)] doi: https://doi.org/10.18087/cardio.2021.2.n1532Шляхто Е.В., Конради А.О., Арутюнов Г.П., и др. Руководство по диагностике и лечению болезней системы кровообращения в контексте пандемии COVID-19 // Российский кардиологический журнал. — 2020. — Т. 25. — № 3. — С. 3801. [Shlyakho EV, Konradi AO, Arutyunov GP, et al. Guidelines for the diagnosis and treatment of circulatory diseases in the context of the COVID-19 pandemic. Russian Journal of Cardiology. 2020;25(3):3801. (In Russ.)] doi: https://doi.org/10.15829/1560-4071-2020-3-3801Banerjee A, Chen S, Pasea L, et al. Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic. Eur J Prev Cardiol. 2021;28(14):1599–1609. doi: https://doi.org/10.1093/eurjpc/zwaa155Ayoubkhani D, Khunti K, Nafilyan V, et al. Post-covid syndrome in individuals admitted to hospital with COVID-19: retrospective cohort study. BMJ. 2021;372:n693. doi: https://doi.org/10.1136/bmj.n693Xie Y, Xu E, Bowe B, et al. Long-term cardiovascular outcomes of COVID-19. Nat Med. 2022;28(3):583–590. doi: https://doi.org/10.1038/s41591-022-01689-3Smeeth L, Thomas SL, Hall AJ, et al. Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med. 2004;351(25):2611–2618. doi: https://doi.org/10.1056/NEJMoa041747Libby P, Luscher T. COVID-19 is, in the end, an endothelial disease. Eur Heart J. 2020;41(32):3038–3044. doi: https://doi.org/10.1093/eurheartj/ehaa623Бурячковская Л.И., Мелькумянц А.М., Ломакин Н.В., и др. Повреждение сосудистого эндотелия и эритроцитов у больных COVID-19 // Consilium Medicum. — 2021. — Т. 23. — № 6. — С. 469–476. [Buryachkovskaya LI, Melkumyants AM, Lomakin NV, et al. Injury of vascular endothelium and erythrocytes in COVID-19 patients. Consilium Medicum. 2021;23(6):469–476. (In Russ.)] doi: https://doi.org/10.26442/20751753.2021.6.200939Ahmed H, Patel K, Greenwood DC, et al. Long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) outbreaks after hospitalization or ICU admission: a systematic review and meta-analysis. J Rehabil Med. 2020;52(5):jrm00063. doi: https://doi.org/10.2340/16501977-2694Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature. 2021;594(7862):259–264. doi: https://doi.org/10.1038/s41586-021-03553-9Арутюнов Г.П., Тарловская Е.И., Арутюнов А.Г., и др. Международный регистр «Анализ динамики коморбидных заболеваний у пациентов, перенесших инфицирование SARS-CoV-2 (aктив SARS-CoV-2)»: анализ 1000 пациентов // Российский кардиологический журнал. — 2020. — Т. 25. — № 11. — С. 4165. [Arutyunov GP, Tarlovskaya EI, Arutyunov AG. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients. Russian Journal of Cardiology. 2020;25(11):4165. (In Russ.)] doi: https://doi.org/10.15829/1560-4071-2020-4165Погосова Н.В., Палеев Ф.Н., Аушева А.К., и др. Последствия COVID-19 на отдаленном этапе после госпитализации // Рациональная фармакотерапия в кардиологии. — 2022. — Т. 18. — № 2. — С. 118–126. [Pogosova NV, Paleev FN, Ausheva AK, et al. Sequelae of COVID-19 at long-term follow-up after hospitalization. Rational Pharmacotherapy in Cardiology. 2022;18(2):118–126. (In Russ.)] doi: https://doi.org/10.20996/1819-6446-2022-04-03Ti LK, Ang LS, Foong TW, et al. What we do when a COVID-19 patient needs an operation: operating room preparation and guidance. Can J Anaesth. 2020;67(6):756–758. doi: https://doi.org/10.1007/s12630-020-01617-4Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020;158(6):1518–1519. doi: https://doi.org/10.1053/j.gastro.2020.02.054Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020;323(14):1406–1407. doi: https://doi.org/10.1001/jama.2020.2565Kampf G, Todt D, Pfaender S, et al. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–251. doi: https://doi.org/10.1016/j.jhin.2020.01.022Письмо Роспотребнадзора от 11.04.2020 № 02/6673-2020-32 «О направлении рекомендаций по применению СИЗ для различных категорий граждан при рисках инфицирования COVID-19» (вместе с МР 3.1/3.5.0172/1-20. 3.1. Профилактика инфекционных болезней. 3.5. Дезинфектология. Рекомендации по применению средств индивидуальной защиты (в том числе многоразового использования) для различных категорий граждан при рисках инфицирования COVID-19. Методические рекомендации).Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017;12:29. doi: https://doi.org/10.1186/s13017-017-0141-6Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27. doi: https://doi.org/10.1186/s13017-020-00306-3De Simone B, Chouillard E, Di Saverio S, et al. Emergency surgery during the COVID-19 pandemic: what you need to know for practice. Ann R Coll Surg Engl. 2020;102(5):323–332. doi: https://doi.org/10.1308/rcsann.2020.0097Ansaloni L, Pisano M, Coccolini F, et al. 2016 WSES guidelines on acute calculous cholecystitis. World J Emerg Surg. 2016;11:25. doi: https://doi.org/10.1186/s13017-016-0082-5Loozen CS, van Santvoort HC, van Duijvendijk P, et al. Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial. BMJ. 2018;363:k3965. doi: https://doi.org/10.1136/bmj.k3965Щеголев А.А. (ред.). Желчекаменная болезнь: учебно-метод. пособие. — М.: РНИМУ, 2015. — 35 с. [Shchegolev AA (red.). Zhelchekamennaya bolezn': uchebno-metod. posobie. Moscow: RNIMU; 2015. 35 s. (In Russ.)]Pisano M, Zorcolo L, Merli C, et al. 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation. World J Emerg Surg. 2018;13:36. doi: https://doi.org/10.1186/s13017-018-0192-3Ten Broek RP, Krielen P, Di Saverio S, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the World Society of Emergency Surgery ASBO working group. World J Emerg Surg. 2018;13:24. doi: https://doi.org/10.1186/s13017-018-0185-2Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033–2040. doi: https://doi.org/10.1182/blood.2020006000Bahloul M, Chaari A, Ben Algia N, et al. Pulmonary embolism in intensive care unit “literature review”. Trends Anaesth Crit. 2012;2(1):25–29. doi: https://doi.org/10.1016/j.tacc.2011.11.005Reyes Valdivia A, Aracil Sanus E, Duque Santos Á, et al. Adapting vascular surgery practice to the current COVID-19 era at a tertiary academic center in Madrid. Ann Vasc Surg. 2020;67:1–5. doi: https://doi.org/10.1016/j.avsg.2020.06.001Ivashchenko AA, Dmitriev KA, Vostokova NV, et al. AVIFAVIR for Treatment of Patients with Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial. Clin Infect Dis. 2021;73(3):531–534. doi: https://doi.org/10.1093/cid/ciaa1176Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the Treatment of Covid-19 — Final Report. N Engl J Med. 2020;383:1813–1826. doi: https://doi.org/10.1056/NEJMoa2007764Jayk Bernal A, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for Oral Treatment of COVID-19 in Nonhospitalized Patients. N Engl J Med. 2022;386(6):509–520. doi: https://doi.org/10.1056/NEJMoa2116044Hammond J, Leister-Tebbe H, Gardner A, et al. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with COVID-19. N Engl J Med. 2022;386(15):1397–1408. doi: https://doi.org/10.1056/NEJMoa2118542Bruzzesi E, Ranzenigo M, Castagna A, et al. Neutralizing monoclonal antibodies for the treatment and prophylaxis of SARS-CoV-2 infection. New Microbiol. 2021;44(3):135–144.RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, et al. Dexamethasone in Hospitalized Patients with COVID-19. N Engl J Med. 2021;384(8):693–704. doi: https://doi.org/10.1056/NEJMoa2021436WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group; Sterne JAC, Murthy S, Diaz JV, et al. Association Between Administration of Systemic Corticosteroids And Mortality Among Critically Ill Patients with COVID-19: A Meta-Analysis. JAMA. 2020;324(13):1330–1341. doi: https://doi.org/10.1001/jama.2020.17023REMAP-CAP Investigators; Gordon AC, Mouncey PR, Al-Beidh F, et al. Interleukin-6 Receptor Antagonists in Critically Ill Patients with COVID-19. N Engl J Med. 2021;384(16):1491–1502. doi: https://doi.org/10.1056/NEJMoa2100433RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021;397(10285):1637–1645. doi: https://doi.org/10.1016/S0140-6736(21)00676-0ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, et al. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with COVID-19. N Engl J Med. 2021;385(9):790–802. doi: https://doi.org/10.1056/NEJMoa2105911Баутин А.Е., Авдеев С.Н., Сейлиев А.А., и др. Ингаляционная терапия сурфактантом в комплексном лечении тяжелой формы COVID-19-пневмонии // Туберкулез и болезни легких. — 2020. — Т. 98. — № 9. — С. 6–12. [Bautin АE, Аvdeev SN, Seyliev АА, et al. А. Inhalation surfactant therapy in the integrated treatment of severe COVID-19 pneumonia. Tuberculosis and Lung Diseases. 2020;98(9):6–12. (In Russ.)] doi: http://doi.org/10.21292/2075-1230-2020-98-9-6-12Avdeev SN, Trushenko NV, Chikina SY, et al. Beneficial effects of inhaled surfactant in patients with COVID-19-associated acute respiratory distress syndrome. Respir Med. 2021;185:106489. doi: https://doi.org/10.1016/j.rmed.2021.106489Tsareva NA, Avdeev SN, Kosanovic D, et al. Inhaled iloprost improves gas exchange in patients with COVID-19 and acute respiratory distress syndrome. Crit Care. 2021;25(1):258. doi: https://doi.org/10.1186/s13054-021-03690-7Авдеев С.Н., Царева Н.А., Мержоева З.М., и др. Практические рекомендации по кислородотерапии и респираторной поддержке пациентов с COVID-19 на дореанимационном этапе // Пульмонология. — 2020. — Т. 30. — № 2. — С. 151–163. [Avdeev SN, Tsareva NA, Merzhoeva ZM, et al. Practical guidelines for oxygen therapy and respiratory support for patients with COVID-19 in the pre-life support. Pulmonology. 2020;30(2):151–163 (In Russ.)] doi: https://doi.org/10.18093/0869-0189-2020-30-2-151-163Faculty of Intensive Care Medicine, Intensive Care Society, Association of Anaesthetists and Royal College of Anaesthetists. Critical care preparation and management in the COVID-19 pandemic. Available at: https://www.icmanaesthesiacovid-19.org/critical-care-preparation-and-management-in-the-covid-19-pandemicOranger M, Gonzalez-Bermejo J, Dacosta-Noble P, et al. Continuous positive airway pressure to avoid intubation in SARS-CoV-2 pneumonia: a two-period retrospective case-control study. Eur Respir J. 2020;56(2):2001692. doi: https://doi.org/10.1183/13993003.01692-2020Bellani G, Grasselli G, Cecconi M, et al. Noninvasive Ventilatory Support of COVID-19 Patients Outside the Intensive Care Units. Ann Am Thorac Soc. 2021;18(6):1020–1026. doi: https://doi.org/10.1513/AnnalsATS.202008-1080OCAvdeev S, Yaroshetskiy A, Tsareva N, et al. Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19. Am J Emerg Med. 2021;39:154–157. doi: https://doi.org/10.1016/j.ajem.2020.09.075Grieco DL, Menga LS, Cesarano M, et al. Effect of helmet noninvasive ventilation vs high-flow nasal oxygen on days free of respiratory support in patients with COVID-19 and moderate to severe hypoxemic respiratory failure: the HENIVOT randomized clinical trial. JAMA. 2021;325(17):1731–1743. doi: https://doi.org/10.1001/jama.2021.4682Perkins GD, Ji C, Connolly BA, et al. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients with Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial. JAMA. 2022;327(6):546–558. doi: https://doi.org/10.1001/jama.2022.0028Авдеев С.Н. Неинвазивная вентиляция легких при новой коронавирусной инфекции COVID-19 // Пульмонология. — 2020. — Т. 30. — № 5. — С. 679–687. [Avdeev SN. Non-invasive ventilation in patients with novel coronavirus infection COVID-19. Pulmonologiya. 2020;30(5):679-687.] (In Russ.) doi: https://doi.org/10.18093/0869-0189-2020-30-5-679-687Pelosi P, Tubiolo D, Mascheroni D, et al. Effects of the prone position on respiratory mechanics and gas exchange during acute lung injury. Am J Respir Crit Care Med. 1998;157(2):387–393. doi: https://doi.org/10.1164/ajrccm.157.2.97-04023Ehrmann S, Li J, Ibarra-Estrada M, et al. Awake Prone Positioning Meta-Trial Group. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021;9(12):1387–1395. doi: https://doi.org/10.1016/S2213-2600(21)00356-8Avdeev SN, Nekludova GV, Trushenko NV, et al. Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID-19 associated acute respiratory distress syndrome. Crit Care. 2021;25(1):35. doi: https://doi.org/10.1186/s13054-021-03472-1WHO Coronavirus (COVID-19) Dashboard. Available from: https://covid19.who.int (accessed: 11.05.2022).Отчет о текущей ситуации по борьбе с коронавирусом. Коммуникационный центр Правительства Российской Федерации. 11.05.2022. [Otchet o tekushei situacii po bor’be s koronavirusom. Available from: Kommunikacionnii centr Pravitel’stva Rossiiskoi Federacii. 11.05.2022. (In Russ.)] Available from: https://стопкоронавирус.рфОковитый С.В. Клиническая фармакология иммунодепрессантов // Обзоры по клинической фармакологии и лекарственной терапии. — 2003. — Т. 2. — № 2. — С. 2–34. [Okovityj SV. Klinicheskaya farmakologiya immunodepressantov. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. 2003;2(2):2–34. (In Russ.)]COVID-19 Excess Mortality Collaborators. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020-21. Lancet. 2022;399(10334):1513–1536. doi: https://doi.org/10.1016/S0140-6736(21)02796-3Shi Y, Wang Y, Shao C, et al. COVID-19 infection: the perspectives on immune responses. Cell Death Differ. 2020;27(5):1451–1454. doi: https://doi.org/10.1038/s41418-020-0530-3Козлов В.А., Савченко А.А., Кудрявцев И.В., и др. Клиническая иммунология. — Красноярск: Поликор, 2020. — 386 с. [Kozlov VA, Savchenko AA, Kudryavcev IV, i dr. Klinicheskaya immunologiya. Krasnoyarsk: Polikor; 2020. 386 s. (In Russ.)]Wang J, Yang W, Chen P, et al. The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysis. PLoS One. 2021;16(4):e0249481. doi: https://doi.org/10.1371/journal.pone.0249481Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 15. 22.02.2022. Available from: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/392/original/ВМР_COVID-19_V15.pdfSnow TAC, Saleem N, Ambler G, et al. Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials. Intensive Care Med. 2021;47(6):641–652. doi: https://doi.org/10.1007/s00134-021-06416-zSelvaraj V, Khan MS, Bavishi C, et al. Tocilizumab in Hospitalized Patients with COVID-19: A Meta Analysis of Randomized Controlled Trials. Lung. 2021;199(3):239–248. doi: https://doi.org/10.1007/s00408-021-00451-9RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021;397(10285):1637–1645. doi: https://doi.org/10.1016/S0140-6736(21)00676-0Patoulias D, Doumas M, et al. Janus kinase inhibitors and major COVID-19 outcomes: time to forget the two faces of Janus! A meta-analysis of randomized controlled trials. Clin Rheumatol. 2021;40(11):4671–4674. doi: https://doi.org/10.1007/s10067-021-05884-4Ma S, Xu C, Liu Sh, et al. Efficacy and safety of systematic corticosteroids among severe COVID‐19 patients: a systematic review and meta‐analysis of randomized controlled trials. Signal Transduct Target Ther. 2021;6(1):83. doi: https://doi.org/10.1038/s41392-021-00521-7RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(8):693–704. doi: https://doi.org/10.1056/NEJMoa2021436The COVID STEROID 2 Trial Group; Munch MW, Myatra SN, Vijayaraghavan BKT, et al. Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial. JAMA. 2021;326(18):1807–1817. doi: https://doi.org/10.1001/jama.2021.18295Jamaati H, Hashemian SMR, Farzanegan B, et al. No clinical benefit of high dose corticosteroid administration in patients with COVID-19: A preliminary report of a randomized clinical trial. Eur J Pharmacol. (2021);897:173947. doi: https://doi.org/10.1016/j.ejphar.2021.173947Oganesyan A., Zykov K, Surovoy Y, et al. Target Groups for a Short Dexamethasone Course among Critically Ill COVID-19 Patients. Crit Care Res Pract. 2021;2021:5557302. doi: https://doi.org/10.1155/2021/5557302Jung C, Wernly B, Fjølner J, et al. and the COVIP study group. Steroid use in elderly critically ill COVID-19 patients. Eur Respir J. 2021;58(4):2100979. doi: https://doi.org/10.1183/13993003.00979-2021Duarte MBO, Leal F, et al. Outcomes of COVID-19 Patients under Cytotoxic Cancer Chemotherapy in Brazil. Cancers (Basel). 2020;12(12):3490. doi: https://doi.org/10.3390/cancers12123490Синицын Е.А., Зыкова А.А., Шамин Р.В., и др. Эффективность и безопасность применения ингаляций ультранизких доз мелфалана в лечении госпитализированных пациентов с COVID-19 // Acta Biomedica Scientifica. — 2022. — Т. 7. — № 2. — С. 12–23. [Sinitsyn EA, Zykova AA, Shamin RV, et al. Efficacy and safety of ultra-low dose inhaled melphalan in the treatment of hospitalized patients with COVID-19. Acta Biomedica Scientifica. 2022;7(2):12–23. (In Russ.)] doi: https://doi.org/10.29413/ABS.2022-7.2.2