Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC20210.15690/vramn.v68i3.598SURGICAL PATHOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ХИРУРГИЧЕСКИХ БОЛЕЗНЕЙCELL THERAPY OF CRITICAL LIMB ISCHEMIA (PROBLEMS AND PROSPECTS)КЛЕТОЧНАЯ ТЕРАПИЯ КРИТИЧЕСКОЙ ИШЕМИИ НИЖНИХ КОНЕЧНОСТЕЙ (ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ)LebedevS. V.ЛебедевС. В.
Russian Federation

кандидат медицинских наук, старший научный сотрудник, врач Центра доказательной медицинской практики и инновационных технологий стационара Медицинского центра Банка России Адрес: 117593, Москва, Севастопольский проспект, д. 66; тел.: (495) 676-80-50

lebedsv@mail.ruKarasevA. V.КарасевА. В.
Russian Federation

заведующий отделением молекулярно-клеточных технологий Медицинского центра Банка России Адрес: 117593, Москва, Севастопольский проспект, д. 66; тел.: (495) 676-80-50

stemcell@inbox.ruKungurtsevV. V.КунгурцевВ. В.
Russian Federation

доктор медицинских наук, профессор, сердечно-сосудистый хирург Медицинского центра Банка России Адрес: 117593, Москва, Севастопольский проспект, д. 66; тел.: (495) 676-83-16

kung-vadim@yandex.ruLokhoninaA. V.ЛохонинаА. В.
Russian Federation

биолог Центра доказательной медицинской практики и инновационных техно- логий стационара Медицинского центра Банка России Адрес: 117593, Москва, Севастопольский проспект, д. 66; тел.: (495) 676-83-74

anastasia.cell@gmail.comKleimenovaE. B.КлейменоваЕ. Б.
Russian Federation

доктор медицинских наук, заведующая Центром доказательной медицинской прак- тики и инновационных технологий стационара Медицинского центра Банка России Адрес: 117593, Москва, Севастопольский проспект, д. 66; тел.: (495) 676-80-11

stemcell@inbox.ruMedical Center of the Bank of Russia, Moscow, Russian FederationМедицинский центр Банка России, Москва, Российская Федерация13032013683Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук334407082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/202

Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology. The article provides a critical analysis of pathogenic prerequisites of stem/progenitor cells for the treatment of patients with a critical limb ischemia in detail the basic results of preclinical and clinical studies on the safety and efficacy of cell technology. Unsolved problems and prospects of practical application are also discussed.

Критическая ишемия нижних конечностей — синдром ряда различных по этиологии и патогенезу заболеваний периферических артерий. Критическая ишемия нижних конечностей характеризуется неблагоприятным прогнозом, высоким уровнем инвалидизации и смертности. Возможности хирургической и консервативной терапии критической ишемии нижних конечностей практически полностью исчерпаны. Определенные надежды возникли в связи с достижениями в области клеточных технологий. В статье представлен критический анализ патогенетических предпосылок применения стволовых/прогениторных клеток для лечения пациентов с критической ишемией нижних конечностей, подробно рассмотрены основные результаты доклинических и клинических исследований безопасности и эффективности клеточных технологий, перспективы их практического внедрения в клиническую практику, а также сформулированы нерешенные вопросы.

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