Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC18710.15690/vramn.v68i5.664SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯTHE STUDY OF DYNAMICS OF CLINICAL AND MOLECULAR PHENOTYPES IN THE GENERALIZED FORM OF MYASTHENIA WITH OPTIMIZED AND COMBINED TREATMENTИССЛЕДОВАНИЕ ДИНАМИКИ КЛИНИЧЕСКОГО И МОЛЕКУЛЯРНОГО ФЕНОТИПА ПРИ МИАСТЕНИИ НА ФОНЕ ОПТИМИЗИРОВАННОГО И КОМБИНИРОВАННОГО РЕЖИМА ЛЕЧЕНИЯDrozdO. A.ДроздО. А.
Russian Federation

PhD student, Department of Nervous Diseases and Neurosurgery, Rostov State Medical University, Resident, Municipal Budgetary Health-Care Institution City Hospital № 8 in Rostov-on-Don Address: 344029, Rostov-on-Don, Nakhichevan Lane, 29; tel.: (863) 250-41-33

drozd.oksy@gmail.comEfremovV. V.ЕфремовВ. В.
Russian Federation

MD, Neurologist, PhD, Associate Professor, Associate Professor, Department of Nervous Diseases and Neurosurgery, Rostov State Medical University. Address: 344029, Rostov-on-Don, Nakhichevan Lane, 29; tel.: (863) 250-41-33

drozd.oksy@gmail.comRomantsovM. G.РоманцовМ. Г.
Russian Federation

Doctor of Medical Science, PhD in Pedagogics, Full Member of the Russian Academy of Natural Sciences. Address: 105037, Moscow, PO Box 47

mr@polysan.ruSarvilinaI. V.СарвилинаИ. В.
Russian Federation

PhD, Clinical Pharmacologist, General Director of Ltd. “Medical Center “Novomeditsina” Address: 344002, Rostov-on-Don, Sotsialisticheskaya St., 74

isarvilina@mail.ruRostov state medical university, Rostov-on-Don, Russian FederationРостовский государственный медицинский университет, Российская ФедерацияI.I. Mechnikov North-Western State Medical University, Saint-Petersburg, Russian FederationСеверо-Западный медицинский университет им. И.И. Мечникова, Санкт-Петербург, Российская ФедерацияLLC «Medical centre «Novomeditsina», Rostov-on-Don, Russian FederationООО «Медицинский центр «Новомедицина», Ростов-на-Дону, Российская Федерация14052013685Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук606407082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/187

The aim of the study was the research of clinical and molecular phenotypes in the generalized form of myasthenia with optimized treatment, which includes the application of basic mode of the treatment and meglumine sodium succinate, and also the combined mode of the treatment, which includes above the mentioned drugs and ozonotherapy. The most expressed improvement of indicators of the clinical and neurologic status (the elimination of motoring breakdown, eye movement disorders, the weaknesses of mimic, respiratory and chewing muscles, bulbar syndrome, the doubling in eyes and ptosis, pharyngeal violations and increase in volume of movement of eyes) was observed in the group of patients receiving the combined therapy. The reduction of the expressiveness of the defeat of the neuromotor device and the decrement of the amplitude of the various degree of M-answer in patients with myasthenia is revealed in the application of the combined therapy in the comparison with the application of the basic and optimized therapy. For the first time we have investigated the dynamics of the intensity of the expression of specific peptides and proteins in blood serum in patients with the application of basic therapy, reamberin and ozonotherapy, which have allowed to open the new mechanisms of the efficiency of the combined therapy of the disease.

Цель работы заключалась в исследовании динамики клинического и молекулярного фенотипа при генерализованной миастении на фоне оптимизированного режима лечения, предполагавшего применение базисной терапии миастении, меглюмина натрия сукцината, а также комбинированного режима лечения, включавшего вышеперечисленные лекарственные препараты и озонотерапию. Достоверное улучшение показателей клинико-неврологического статуса (устранение двигательных расстройств, глазодвигательных нарушений, слабости мимической, дыхательной и жевательной мускулатуры, бульбарного синдрома, двоения в глазах и птоза, глоточных нарушений) наблюдалось у пациентов, получавших комбинированный режим терапии. Выявлено достоверное уменьшение степени выраженности поражения нейромоторного аппарата и декремента амплитуды М-ответа различной степени у пациентов с миастенией при приеме комбинированной терапии по сравнению с приемом базисной и оптимизированной терапии. Впервые исследована динамика интенсивности экспрессии молекул пептидов и белков в сыворотке крови при приеме базисной, оптимизированной и комбинированной терапии, позволившая раскрыть новые механизмы эффективности комбинированной терапии заболевания.

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