Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC18310.15690/vramn.v68i5.660ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИNEUROENDOCRINE TUMORS OF DIGESTIVE SYSTEM: MORPHOLOGIC SPECTRUM AND CELL PROLIFERATION (KI67 INDEX)НЕЙРОЭНДОКРИННЫЕ ОПУХОЛИ ПИЩЕВАРИТЕЛЬНОЙ СИСТЕМЫ: МОРФОЛОГИЧЕСКИЙ СПЕКТР И КЛЕТОЧНАЯ ПРОЛИФЕРАЦИЯ (ИНДЕКС KI67)DelektorskayaV. V.ДелекторскаяВ. В.
Russian Federation

PhD, Head of the Histochemistry and Electron Microscopy Laboratory, N. N. Blokhin Russian Cancer Research Center of RAMS Address: 115478, Moscow, Kashirskoye Highway 24; tel.: (499) 324-61-11

delektorskaya@yandex.ruKushlinskiiN. E.КушлинскийН. Е.
Russian Federation

PhD, Professor, RAMS cor. member, Head of the Clinical Biochemistry Laboratory, N. N. Blokhin Russian Cancer Research Center of RAMS Address: 115478, Moscow, Kashirskoye Highway 24; tel.: (499) 324-11-59

biochimia@mtu-net.ruN.N. Blokhin Russian Cancer Researche Centre of RAMS, Moscow, Russian FederationРоссийский онкологический научный центр им. Н.Н. Блохина РАМН, Москва, Российская Федерация14052013685Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук283707082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/183

This review deals with the analysis of up-to-date concepts of different types of human neuroendocrine tumors of the digestive system. It summarizes the information on the specifics of recent histological classifications and criteria of morphological diagnosis accounting histological, ultrastructural and immunohistochemical parameters. Current issues of the nomenclature as well as various systems of grading and staging are discussed. In the light of these criteria the results of the own research clinical value of the determination of cell proliferation in primary and metastatic gastroenteropancreatic neuroendocrine neoplasms on the basis of evaluation of the Ki67 antigen expression are also presented.

Обзор посвящен анализу современных представлений о различных типах нейроэндокринных новообразований пищеварительной системы человека. В нем обобщены сведения об особенностях последних гистологических классификаций и критериях морфологической диагностики с учетом гистологических, ультраструктурных, и иммуногистохимических параметров. Обсуждаются вопросы номенклатуры, а также системы градации и стадирования. В свете этих критериев также представлены данные собственных исследований по клинической значимости определения пролиферативной активности клеток первичных и метастатических нейроэндокринных новообразований желудочно-кишечного тракта и поджелудочной железы на основе оценки экспрессии антигена Ki67.

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