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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">18158</article-id><article-id pub-id-type="doi">10.15690/vramn18158</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>STOMATOLOGY: CURRENT ISSUES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ СТОМАТОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Biomimetic materials and minimally invasive techniques in contemporary prosthodontics: innovative solutions for preserving natural tooth structure</article-title><trans-title-group xml:lang="ru"><trans-title>Биомиметические материалы и минимально-инвазивные методики в современной ортопедической стоматологии: инновационные решения для сохранения естественной структуры зубов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0789-2564</contrib-id><name-alternatives><name xml:lang="en"><surname>Nalbandyan</surname><given-names>Karen G.</given-names></name><name xml:lang="ru"><surname>Налбандян</surname><given-names>Карен Георгиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Professor</p></bio><bio xml:lang="ru"><p>доцент</p></bio><email>qi.mozg@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2834-5874</contrib-id><contrib-id contrib-id-type="spin">3620-7094</contrib-id><name-alternatives><name xml:lang="en"><surname>Kirushin</surname><given-names>Maxim A.</given-names></name><name xml:lang="ru"><surname>Кирюшин</surname><given-names>Максим Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Professor</p></bio><bio xml:lang="ru"><p>доцент</p></bio><email>Kirushinma@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5038-8339</contrib-id><contrib-id contrib-id-type="spin">4649-8655</contrib-id><name-alternatives><name xml:lang="en"><surname>Ertuvkhanov</surname><given-names>Marat Z.</given-names></name><name xml:lang="ru"><surname>Эртувханов</surname><given-names>Марат Зайнулабидович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>Marat.ertuvkhanov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3564-3316</contrib-id><name-alternatives><name xml:lang="en"><surname>Yakubov</surname><given-names>Mansurjon I.</given-names></name><name xml:lang="ru"><surname>Якубов</surname><given-names>Мансурджон Илхомджонович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yakubovmansurj@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-8440-8667</contrib-id><name-alternatives><name xml:lang="en"><surname>Shcherbinin</surname><given-names>Nikita A.</given-names></name><name xml:lang="ru"><surname>Щербинин</surname><given-names>Никита Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>drscherbinin@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5917-4560</contrib-id><contrib-id contrib-id-type="spin">3069-8103</contrib-id><name-alternatives><name xml:lang="en"><surname>Katkova</surname><given-names>Anastasia K.</given-names></name><name xml:lang="ru"><surname>Катькова</surname><given-names>Анастасия Константиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>a.katkovaa@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-7544-5217</contrib-id><name-alternatives><name xml:lang="en"><surname>Garyaeva</surname><given-names>Danara V.</given-names></name><name xml:lang="ru"><surname>Гаряева</surname><given-names>Данара Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>danarka48@gmail.com</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-4117-970X</contrib-id><name-alternatives><name xml:lang="en"><surname>Yanovskaya</surname><given-names>Yana V.</given-names></name><name xml:lang="ru"><surname>Яновская</surname><given-names>Яна Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yanovskaya281@gmail.com</email><xref ref-type="aff" rid="aff6"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия УДП РФ</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">New Iceberg Dental Trauma Centre</institution></aff><aff><institution xml:lang="ru">Центр дентальной травматологии New Iceberg</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Kuban State Medical University</institution></aff><aff><institution xml:lang="ru">Кубанский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Stavropol State Medical University</institution></aff><aff><institution xml:lang="ru">Ставропольский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Volgograd State Medical University</institution></aff><aff><institution xml:lang="ru">Волгоградский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-09-22" publication-format="electronic"><day>22</day><month>09</month><year>2026</year></pub-date><volume>81</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>213</fpage><lpage>223</lpage><history><date date-type="received" iso-8601-date="2025-12-07"><day>07</day><month>12</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-07-03"><day>03</day><month>07</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Издательство "Педиатръ"</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-03-22"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/18158">https://vestnikramn.spr-journal.ru/jour/article/view/18158</self-uri><abstract xml:lang="en"><p>Contemporary prosthodontics is shifting from retention-based full-coverage designs to biomimetic, tissue-sparing solutions that prioritize maximal enamel preservation, judicious dentin management, and sustained function and aesthetics. Aim. To synthesize current evidence on biomimetic materials and minimally invasive techniques in prosthodontics and to appraise their clinical reliability. Materials and methods. The review followed PRISMA 2020, with searches in PubMed/MEDLINE, Scopus, Web of Science, Embase, Cochrane Library, and ScienceDirect (2020–2025). A total of 2,186 records were identified; after screening and full-text assessment, 71 publications were included in the synthesis. At the level of adhesive protocols, biomimetic luting relies on universal systems containing 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP); selective enamel etching improves retention and marginal adaptation compared with pure self-etch, while immediate dentin sealing is associated with higher overall survival of indirect restorations at a comparable level of postoperative comfort. For single-unit indirect restorations, self-adhesive resin cements are non-inferior to conventional resin cements when the substrate is properly conditioned. By materials, lithium disilicate used for partial-coverage restorations shows approximately 94% three-year survival with durable long-term outcomes; resin-matrix CAD/CAM materials provide acceptable mid-term reliability with prudent case selection; for zirconia, combined surface conditioning with phosphate-containing primers is critical. Minimally invasive designs allow restoration of anatomy and, when needed, occlusal vertical dimension without extensive preparation; debonding remains the main risk for adhesive solutions and is typically manageable by rebonding. Biomimetic materials and minimally invasive protocols constitute a predictable, tissue-conserving strategy for prosthodontic rehabilitation; enamel-oriented adhesion, appropriate zirconia surface conditioning, and an end-to-end digital workflow remain pivotal.</p></abstract><trans-abstract xml:lang="ru"><p>В ортопедической стоматологии происходит переход от ретенционных полнокоронковых конструкций к биомиметическим и щадящим решениям, где приоритетом становится максимальное сохранение эмали при рациональной работе с дентином и поддержание высокой эстетики и функции. Цель работы — систематизировать современные данные о биомиметических материалах и минимально-инвазивных методиках в ортопедической стоматологии и оценить их клиническую надежность. Обзор выполнен по методологии PRISMA 2020 с поиском в PubMed/MEDLINE, Scopus, Web of Science, Embase, Cochrane Library и ScienceDirect (2020–2025 гг.). Идентифицировано 2186 записей; после скрининга и полнотекстовой оценки в работу включена 71 публикация. На уровне адгезивных протоколов биомиметическая фиксация опирается на универсальные системы с 10-метакрилоилоксидецилдигидрогенфосфатом, причем селективное протравливание эмали повышает ретенцию и качество краевой адаптации по сравнению с чистым самопротравливанием, а немедленное герметизирование дентина ассоциировано с ростом интегральной выживаемости непрямых реставраций при сопоставимом уровне послеоперационного комфорта; самоадгезивные цементы на основе композитных смол при фиксации одиночных непрямых конструкций не уступают традиционным композитным цементам при корректной подготовке субстрата. Литийдисиликат для частичных адгезивных реставраций демонстрирует трехлетнюю выживаемость около 94% и устойчивые долгосрочные исходы; гибридные CAD/ CAM-материалы на матрице из композитных смол обеспечивают приемлемую среднесрочную надежность при взвешенном выборе показаний; для циркония критична комбинированная подготовка поверхности с использованием фосфат-содержащих праймеров. Конструктивные решения, реализующие принцип минимальной инвазивности, позволяют восстанавливать анатомию и при необходимости окклюзионную высоту без масштабной препаровки; ведущим риском для адгезивных конструкций остается дебондинг, как правило, устранимый повторной фиксацией. Биомиметические материалы и минимально-инвазивные методики формируют предсказуемую, тканесберегающую стратегию ортопедической реабилитации, ключевыми остаются эмаль-ориентированная адгезия, корректная подготовка циркония и полноценный цифровой цикл планирования и исполнения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biomimetic materials</kwd><kwd>minimally invasive dentistry</kwd><kwd>adhesive system</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биомиметические материалы</kwd><kwd>минимально-инвазивная стоматология</kwd><kwd>адгезивные системы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ioannidis A, Pitta J, Panadero RA, et al. Rehabilitation Strategies and Occlusal Vertical Dimension Considerations in the Management of Worn Dentitions: Consensus Statement from SSRD, SEPES, and PROSEC Conference on Minimally Invasive Restorations. 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