Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC1794610.15690/vramn17946PHARMACOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ФАРМАКОЛОГИИ И ФАРМАЦИИResearch ArticlePharmacological Regulation Possibilities of HIF for Its’ Mediated Pathologies in Clinical PracticeВозможности фармакологической регуляции HIF для коррекции опосредованных ими патологических состояний в клинической практикеhttps://orcid.org/0000-0002-0953-7993NovikovVasiliy E.НовиковВасилий Егорович
Russian Federation

MD, PhD, Professor

д.м.н., профессор

novikov.farm@yandex.ruhttps://orcid.org/0000-0002-9595-69822888-6150LevchenkovaOlga S.ЛевченковаОльга Сергеевна
Russian Federation

MD, PhD, Associate Professor

д.м.н., доцент

levchenkova-o@yandex.ruSmolensk State Medical UniversityСмоленский государственный медицинский университет150820247932612700802202413052024Copyright ©; 2024, "Paediatrician" Publishers LLCCopyright ©; 2024, Издательство "Педиатръ"2024"Paediatrician" Publishers LLCИздательство "Педиатръ"https://creativecommons.org/licenses/by-nc-nd/4.0/https://vestnikramn.spr-journal.ru/jour/article/view/17946

The review is devoted to the experimental and clinical data analysis about the effectiveness and safety of drugs whose main target is the hypoxia-inducible factor HIF. The use of HIF inhibitors continues to be widely researched and is trying to enter practice in the treatment of cancers, such as the HIF-2α inhibitor belzutifan, which is approved for treatment of cancers associated with von Hippel–Lindau disease (VHL). HIF stabilizers can initiate preconditioning and be used in acute predictable myocardial or cerebral ischemia (during cardiac or vascular surgery). Long-term administration of some of them, in particular prolyl hydroxylase inhibitors, in the treatment of renal anemia cannot exclude the activation of neoangiogenesis, which is associated with the risk of pro-oncogenic effect as well as an increased risk of thrombosis and cardiovascular events.

Проведен анализ экспериментальных и клинических исследований эффективности и безопасности лекарственных средств, основной мишенью действия которых является гипоксией индуцированный фактор (HIF). Ингибиторы HIF продолжают широко исследоваться с целью их внедрения в клиническую практику, прежде всего в лечение раковых опухолей, например, ингибитор HIF-2α белзутифан, разрешенный к применению при опухолях, ассоциированных с болезнью фон Гиппеля–Линдау (VHL). Применение индукторов транскрипционного фактора HIF инициирует прекондиционирование, что может быть востребовано в случае острой предсказуемой ишемии миокарда или головного мозга (при операциях на сердце или сосудах). Продолжительное назначение некоторых из них, в частности ингибиторов пролилгидроксилазы, в лечении анемии при хронической болезни почек не может исключать активацию неоангиогенеза, что сопряжено с риском проонкогенного действия, а также повышенный риск тромбозов и сердечно-сосудистых нарушений.

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