Annals of the Russian academy of medical sciences

Вестник Российской академии медицинских наук

0869-60472414-3545

"Paediatrician" Publishers LLC

178

10.15690/vramn.v68i6.673

РATHOPHYSIOLOGY: CURRENT ISSUES

АКТУАЛЬНЫЕ ВОПРОСЫ ПАТОФИЗИОЛОГИИ

NERVOUS REGULATION ОF THYROID FUNCTION

НЕРВНАЯ РЕГУЛЯЦИЯ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ

Lychkova

A. E.

Лычкова

А. Э.

Russian Federation

PhD, Head of the Clinical Physiology Laboratory, Central Research Institute of Gastroenterology Department of Moscow Public Health Address: 129343, Moscow, Entuziastov highway, 86; tel.: (499) 180-41-12

lychkova@mail.ru

Central Gastroenterology Research Institute, Moscow, Russian FederationЦентральный научно-исследовательский институт гастроэнтерологии, Москва, Российская Федерация

19062013

686

Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciences

Вестник Российской академии медицинских наук

495507082015

1970

"Paediatrician" Publishers LLC

Издательство "Педиатръ"

https://vestnikramn.spr-journal.ru/jour/about/submissions

https://vestnikramn.spr-journal.ru/jour/article/view/178

Review examines the autonomic regulation of thyroid function. Review examines the issues of autonomic regulation of the thyroid gland. Activation of the central α-adrenergic mechanisms increases the release of thyroid-stimulating hormone of pituitary mainly due to the stimulation of its secretion. Dopamine inhibits the secretion of this hormone, acting on D2-receptors tireotropotsitov. Acetylcholine and other cholinomimetics inhibit the functional activity of thyrociteы with the participation of muscarinic receptors. Along the sympathetic and parasympathetic special attention paid to the role of the serotonergic division of vegetative system. Serotonin can inhibit the secretion of thyrotropin by the pituitary gland, but has a direct stimulatory effect on thyrocytes. This stimulatory effect is mediated by the serotonin 5-HT2 receptors. In hypothyroidism synthesis and metabolism of serotonin in the brain are slowed down. Depression is accompanied by inhibition of the enzyme activity deiodinase type 2, thereby reducing the concentration of serotonin. Activation of 5-HT1 receptor lead to increased levels of intracellular calcium, causing inhibition of the promoter of calcitonin gene-associated peptide.

В обзоре рассмотрены вопросы вегетативной регуляции функции щитовидной железы. Активация центральных α-адренергических механизмов увеличивает высвобождение тиреотропного гормона гипофиза преимущественно за счет стимуляции его секреции. Дофамин угнетает секрецию этого гормона, воздействуя на D₂-рецепторы тиреотропоцитов. Ацетилхолин и другие холиномиметики угнетают функциональную активность тиреоцитов при участии мускариновых рецепторов. Наряду симпатическим и парасимпатическим отделом особое внимание уделено роли серотонинергического отдела вегеьтативной нервной системы. Серотонин может блокировать секрецию тиреотропина гипофизом, однако оказывает прямое стимулирующее влияние на тиреоциты. Этот стимуляторный эффект серотонина опосредован 5-НТ₂-рецепторами. При гипотиреозе угнетен синтез и метаболизм серотонина в мозге. Депрессия сопровождается угнетением активности фермента дейодиназы типа 2, что способствует снижению содержания серотонина при депрессии. Активация 5-НТ1-рецептора приводит к увеличению содержания внутриклеточного кальция, вызывая торможение активности промоутера кальцитонин ген-ассоциированного пептида.

thyroid glandnervous regulation

щитовидная железанервная регуляция

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