Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC17010.15690/vramn.v68i7.714PULMONOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПУЛЬМОНОЛОГИИMYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESISМИКОПЛАЗМЫ И ХЛАМИДИИ КАК ЭТИОЛОГИЧЕСКИЕ ФАКТОРЫ БРОНХИАЛЬНОЙ АСТМЫ С ПОЗИЦИЙ ЭТНОГЕНЕЗАSharaviiO. A.ШаравииА. О.
Russian Federation

PhD, Senior Research Worker, Medical Research Institute for Northern Problems Siberian Branch of RAMS Address: 660022, Krasnoyarsk, Partizan Zheleznyaka St., 3G; tel.: (391)228-06-83

impn@impn.ruSmirnovaS. V.СмирноваС. В.
Russian Federation

PhD, Professor, Deputy Director for Research, Medical Research Institute for Northern Problems Siberian Branch of RAMS Address: 660022, Krasnoyarsk, Partizan Zheleznyaka St., 3G; tel.: (391) 228-06-81

svetvita@mail.ruMedical Research Institute for Northern Problems, Siberian Branch of RAMS, Krasnoyarsk, Russian FederationНаучно-исследовательский институт медицинских проблем Севера СО РАМН, Красноярск, Российская Федерация19072013687Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук576007082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/170

Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results. We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum.

Цель: изучить распространенность и клинические особенности микоплазмоза и хламидиоза у больных различными патогенетическими формами бронхиальной астмы (БА) с учетом этнической принадлежности. Пациенты и методы. В исследование включены 239 человек – европеоиды и монголоиды гг. Красноярска и Кызыла, больные БА, средней степени тяжести в стадии обострения и практически здоровые. Определяли антигены Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci, Chlamydia trachomatis в мазках со слизистой оболочки ротоглотки и антитела к ним в сыворотке периферической крови. Результаты. Установлена высокая распространенность микоплазмоза и хламидиоза у жителей Восточной Сибири, больных БА независимо от ее патогенетической формы, по сравнению с группой контроля. Определены этнические особенности специфического иммунного ответа: IgM к М. pneumoniae выявляются у европеоидов чаще, чем у монголоидов, а IgM – к С. pneumoniae и к C. trachomatis, антигены C. trachomatis чаще обнаруживают у монголоидов, чем у европеоидов. В качестве клинических эквивалентов диагностики микоплазмоза и хламидиоза у больных БА установлены: субфебрильная температура тела; кашель неинтенсивного, но навязчивого характера со скудной слизистой и слизисто-гнойной мокротой; одышка смешанного характера. Выводы. Микоплазмы и хламидии являются значимыми этиологическими факторами бронхиальной астмы. Выявлены особенности иммунного реагирования в зависимости от этнической принадлежности. Необходимо учитывать клинические маркеры микоплазмоза и хламидиоза при бронхиальной астме с целью своевременной диагностики и эрадикации возбудителей инфекции.

bronchial asthmamycoplasmosischlamydiosisthe frequencyethnic and clinical peculiaritiesбронхиальная астмамикоплазмозхламидиозчастота встречаемостиэтнические и клинические особенности1. Buzoleva L.S. Saprozoonoses: Yesterday, Today and Tomorrow. Byull.SO RAMN = Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2011; 4: 64–71.2. Granitov V.M. Khlamidiozy [Chlamydioses].Мoscow: Meditsinskaya kniga. 2002. 192 p.3. Zaitseva O.V., Levshin I.B., Lavrent'ev A.V., Zaitseva S.V., Skirda T.A., Martynova V.R., Kolkova N.I., Samsygina G.A. The Prevalence of bronchial asthma associated with Chlamydia pneumonia in children and clinical presentation. Pediatriya = Pediatrics. 1999; 1: 29–33.4. Kuz'menko L.G., Sokolov A.L., Kapustin I.V., Aleshkin V.A., Blyakher M.S., Skirda T.A., Bychkov V.A., Kirillov M.Yu., Zakharui S. Cytomegalovirus, mycoplasma, pneumocystosis and chlamydia infections rate in children with bronchial asthma. Pediatriya = Pediatrics. 1999; 1: 15–20.5. Ovsyannikov D.Yu., Kuz'menko L.G., Nazarova T.I. i dr. Bronchial asthma in children associated with mycoplasma and chlamydial infections. Allergologiya i immunologiya = Allergology and Immunology. 2004; 3: 146–149.6. Spichak T.V. The role of Chlamydia infection in children with bronchial asthma. Pediatriya = Pediatrics. 2009; 2: 19–26.7. Bartlett D.D. Infektsii dykhatel'nykh putei [Respiratory Tract Infections]. St. Petersburg: Nevskii dialekt. 2000. 192 p.8. Koroleva E.G., Osidak L.V., Mil'kint K.K. et al. Mycoplasma infection in children with bronchial asthma. Pul'monologiya = Pulmonology. 2002; 5: 13–16.9. Khamitov R.F., Novozhenov V.G., Pal'mova L.Yu. et al. The prevalence of antibodies to Chlamydia pneumoniae and Mycoplasma pneumoniae in patients with bronchial asthma. Pul'monologiya = Pulmonology. 2003; 2: 31–34.10. Koroleva E.G., Osidak L.V., Mil'kint K.K. et al. Mycoplasma infection in children with asthma. Pul'monologiya = Pulmonology. 2002; 5: 13–16.11. Khamitov R.F., Novozhenov V.G., Pal'mova L.Yu. et al. Prevalence of antibodies to the carrier Chlamydia pneumoniae and Mycoplasma pneumoniae in patients with bronchial asthma. Pul'monologiya = Pulmonology. 2003; 2: 31–34.12. Yano T., Ichikawa Y., Komatu S. et al. Assosiation of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma. Am. J. Respir. Crit. Care Med. 1994; 149 (5): 1348–1353.13. Kozlova V.I., Pukhner A.F. Virusnye, khlamidiinye i mikoplazmennye zabolevaniya genitalii [Viral, mycoplasma and chlamydial genital diseases]. Мoscow: Triada-Kh. 2003. 439 p.