Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC16910.15690/vramn.v68i7.713PULMONOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПУЛЬМОНОЛОГИИASSOCIATION OF POLYMORPHISM RS6737848 IN THE SOCS5 GENE WITH BRONCHIAL ASTHMAАССОЦИАЦИЯ ПОЛИМОРФИЗМА RS6737848 ГЕНА SOCS5 С БРОНХИАЛЬНОЙ АСТМОЙSaltykovaI. V.СалтыковаИ. В.
Russian Federation

PhD, Junior Research Worker, Central Research Laboratory of Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 52-99-16

ira.saltikova@mail.ruFreidinM. B.ФрейдинМ. Б.
Russian Federation

PhD, Senior Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56

mfreidin@medgenetics.ruBraginaE. Yu.БрагинаЕ. Ю.
Russian Federation

PhD, Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56

elena.bragina72@gmail.comOgorodovaL. M.ОгородоваЛ. М.
Russian Federation

PhD, Professor, RAMS cor. member, Head of the Pediatrics Department of the Medical Faculty with Children's Diseases Course, Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 53-10-22

lm.ogorodova@mail.ruPuzyrevV. P.ПузыревВ. П.
Russian Federation

PhD, Professor, RAMS academician, Director of the Research Institute of Medical Genetics SB RAMS, Head of the Laboratory of Population Genetics Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 51-22-28

valery.puzyrev@medgenetics.ruSiberian State Medical University, Tomsk, Russian FederationСибирский государственный медицинский университет, Томск, Российская ФедерацияResearch Institute of Medical Genetics, Tomsk, Russian FederationНаучно-исследовательский институт медицинской генетики СО РАМН, Томск, Российская Федерация19072013687Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук535607082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/169

Aim: to investigate the role of polymorphic variants of immune-response modifying genes in predisposition to asthma. Patients and methods. The analysis of restriction fragments length polymorphism was used to investigate 10 single-nucleotide polymorphisms: IFNG rs2069705, IFNGR2 rs17880053, IL4 rs 2070874, IL4RA rs 1805010, GATA3 rs10905277, TBX21 rs11652969, PIASY rs3760903, PIAS3 rs12756687, STAT5β rs16967593, and SOCS5 rs6737848 in 106 asthma patients and 115 healthy people. Results. The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model (р =0,05, OR =0,338, 95%CI 0,158–0,723) and in dominant model (р =0,02, OR =0,284, CI 0,126–0,638). None of the polymorphisms of the studied genes was associated with total IgE levels. Conclusions. This is the first report on the association of rs6737848 SOCS5 with asthma.

Цель исследования: произвести анализ ассоциаций полиморфных вариантов генов регуляции иммунного ответа с бронхиальной астмой. Пациенты и методы. Проанализировано 10 однонуклеотидных замен генов IFNG (rs2069705), IFNGR2 (rs17880053), IL4 (rs2070874), IL4RA (rs1805010), GATA3 (rs10905277), TBX21 (rs11652969), PIASY (rs3760903), PIAS3 (rs12756687), STAT5β (rs16967593), SOCS5 (rs6737848) путем полиморфизма длин рестрикционных фрагментов у 106 больных бронхиальной астмой и 115 здоровых индивидов. Результаты. С помощью логистической регрессии показана ассоциация полиморфизма rs6737848 гена SOCS5 с бронхиальной астмой в аддитивной и доминантной модели (р =0,05, OR =0,338, 95% CI 0,158–0,723; р =0,02, OR =0,284, CI 0,126–0,638, соответственно). Не обнаружено вклада полиморфизма исследованных генов в изменчивость уровня общего IgE. Выводы. Полученные данные свидетельствуют о патогенетической роли полиморфизма rs6737848 гена SOCS5 в отношении бронхиальной астмы.

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