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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">157</article-id><article-id pub-id-type="doi">10.15690/vramn.v68i8.721</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>STOMATOLOGY: CURRENT ISSUES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ СТОМАТОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">MODERN CONCEPTS OF ETIOLOGY, PATHOGENESIS AND TREATMENT APPROACHES TO ENDO-PERIO LESIONS</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ ОБ ЭТИОЛОГИИ, ПАТОГЕНЕЗЕ И ПОДХОДАХ К ЛЕЧЕНИЮ ЭНДОДОНТО-ПАРОДОНТАЛЬНЫХ ПОРАЖЕНИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grudyanov</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Грудянов</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, professor, Head of the Department of Periodontology of Central Research Institute of Dental and Maxillofacial Surgery, Professor of the Department of Dentistry of I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Timur Frunze St., 16; tel.: (499) 246-82-58</p></bio><email>grudyanov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Makeeva</surname><given-names>M. K.</given-names></name><name xml:lang="ru"><surname>Макеева</surname><given-names>М. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate of the Department of Periodontology of Central Research Institute of Dental and Maxillofacial Surgery. Address: 119992, Moscow, Timur Frunze St., 16; tel.: (499) 246-13-34</p></bio><email>abrek93@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pyatigorskaya</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Пятигорская</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Deputy director for Research of Research Institute of Pharmacy, professor of the Department of Industrial Pharmacy, I.M. Sechenov First Moscow State Medical University. Address: 117418, Moscow, Nakhimovsky Ave, 45; tel.: (499) 128-57-55</p></bio><email>osipova-mma@list.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central research institute of dental and maxillofacial surgery, Moscow, Russian Federation&#13;
First Moscow state medical university named after I.M. Setchenov, Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии, Москва, Российская Федерация &#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central research institute of dental and maxillofacial surgery, Moscow, Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии, Москва, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">I.M. Setchenov First Moscow state medical university, Russian Federation</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-08-19" publication-format="electronic"><day>19</day><month>08</month><year>2013</year></pub-date><volume>68</volume><issue>8</issue><issue-title xml:lang="en">Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciences</issue-title><issue-title xml:lang="ru">Вестник Российской академии медицинских наук</issue-title><fpage>34</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2015-08-07"><day>07</day><month>08</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, Издательство "Педиатръ"</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/157">https://vestnikramn.spr-journal.ru/jour/article/view/157</self-uri><abstract xml:lang="en"><p><italic>A combination of periodontitis and pulp or periapical tissues inflammation in one tooth is known as endo-periodontal lesions. Such kind of lesion is serious problem of modern dentistry. It was found that pathogenic microflora of periodontal pocket and root canal of tooth with eno-perio lesion is almost the equal and consist of anaerobic microorganisms. Pathogenic effects have not only microorganisms but also their life products. Apical foramen, lateral and additional canals are physiological ways for pathogens migration. Inflammatory processes in these structures complicate each other. Lack of information among dentists about treatment possibilities of endo-perio lesions is a main reasons of extraction such kind of teeth. Simultaneous elimination of pathogens both from periodontal pocket and root canal is a key factor for effective treatment. Periodontal status is main factor for prognosis of tooth with endo-perio lesion, because of it treatment of endo-perio lesions should consist of two stages: infection elimination and regeneration of tooth-supported structures.</italic></p><p> </p></abstract><trans-abstract xml:lang="ru"><p><italic>C</italic><italic>очетание пародонтита и осложнений кариеса (пульпита и периодонтита) в области одного зубочелюстного сегмента, называемое эндодонто-пародонтальным поражением, представляет серьезную проблему современной стоматологии. Установлено, что патогенная микрофлора пародонтальных карманов и корневых каналов зубов с эндодонто-пародонтальным поражением практически идентична и представляет собой преимущественно анаэробные микроорганизмы. Патогенным действием обладают не только микроорганизмы, но и продукты их жизнедеятельности. Апикальное отверстие, боковые и дополнительные каналы являются физиологическими путями распространения инфекции между пульпой и пародонтом, формирующиеся в процессе эмбрионального развития, по которым патогенные микроорганизмы могут мигрировать, приводя к взаимному отягощению воспалительных процессов. В литературе эндодонто-пародонтальные поражения классифицируют на основании первичного источника инфекции, а именно эндодонтические, пародонтальные и истинно комбинированные поражения. Причиной частых удалений является недостаточная информированность врачей о возможностях и этапах лечения этой группы поражений. Эффективное лечение эндодонто-пародонтальных поражений подразумевает одновременное устранение микробного фактора из системы корневых каналов и пародонтального кармана, а затем, по возможности, — восстановление костных опорных структур, от которых зависит прогноз функционирования зуба в зубочелюстной системе.</italic></p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>endo-perio lesions</kwd><kwd>endodontic</kwd><kwd>tooth prognosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эндодонто-пародонтальные поражения</kwd><kwd>эндодонтия</kwd><kwd>прогноз зуба</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	Alekhanova I.F. Depul'pirovanie pri parodontite: kliniko-immunologicheskie aspekty. Avtoref. diss. … kand. med. nauk [Endodontically treated tooth in periodontitis: clinical and immunological aspects. Author’s abstract]. 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