Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC15510.15690/vramn.v68i8.719INFECTIOUS DISEASES: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ИНФЕКЦИОННЫХ БОЛЕЗНЕЙEPIDEMIOLOGY-BIOLOGICAL FEATURES OF THE ACUTE INTESTINAL INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUSОCТРЫЕ КИШЕЧНЫЕ ИНФЕКЦИИ, ВЫЗВАННЫЕ STAPHYLOCOCCUS AUREUS: ЭПИДЕМИОЛОГО-БИОЛОГИЧЕСКИЕ ОСОБЕННОСТИGolubnichayaV. N.ГолубничаяВ. Н.
Ukraine

MD, associate professor of the Department Hygiene and Ecology of Microbiology, Virology and Immunology of Sumy State University

golubnichiy@ukr.netMalyshN. G.МалышН. Г.
Ukraine

MD, assistant of the Department of Infection Disease with Epidemiology of Sumy State University

ninamalysh@mail.ruSumy State University, Sumy, UkraineСумский государственный университет, Украина19082013688Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук242707082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/155

Nowadays the structure of acute intestinal infections pathogens changed substantially. It is caused by constant evolution of bacteria and involvement of the opportunistic pathogens in the pathological processes. The aim of the study was to investigate the prevalence of the acute intestinal infections caused by staphylococci in the North-Eastern region of Ukraine, to determine the pathogenic factors in isolated pathogens. The materials for the study were the data of statistical reporting of Sumy regional sanitary-epidemiological station. Biological properties of the 50 Staphylococcus aureus strains were investigated. In the work used The descriptive and analytical techniques of the epidemiological, bacteriological and statistical methods were used. In the 2007–2012 the incidence of acute intestinal infections caused by staphylococci was in the range 17,1–20,3 on the 100 thousand. 2 year-old children were prevailed in the age structure. The largest numbers of cases were recorded in January, February, April, June and August. Strains of Staphylococcus aureus, isolated from the patients were characterized by a wide spectrum of pathogenic and persistence factors. Anti-lisozym activity was in 100% of the investigated cultures, anti-interferon and anti-complement activity were detected in 96,0 and 64,0% stains, ability to adhesion was present in 36,0% stains. At the same time anti-lisozym, anti-interferon and anti-complement activity were showed in the 52,0% stains of the Staphylococcus aureus. These data characterize negatively predicted for the near future regional trends in morbidity.

В настоящее время существенно изменилась структура возбудителей острых кишечных инфекций, что связано с постоянной эволюцией бактерий и вовлечением в патологические процессы условно-патогенных микроорганизмов. Целью исследования явилось изучение распространенности в Северо-Восточном регионе Украины острых кишечных инфекций стафилококковой этиологии, определение наличия у выделенных возбудителей факторов патогенности. Материалами для работы послужили данные отраслевой статистической отчетности Сумской областной санитарно-эпидемиологической станции. Были исследованы биологические свойства у 50 штаммов Staphylococcus aureus. В работе применяли дескриптивные и аналитические приемы эпидемиологического метода исследований, бактериологические и статистические методы. Уровень заболеваемости острыми кишечными инфекциями стафилококковой этиологии в 2007–2012 гг. находился в диапазоне 17,1–20,3 на 100 тыс. населения. В возрастной структуре превалировали дети в возрасте до 2 лет. Наибольшее число случаев регистрировали в январе, феврале, апреле, июне и августе. Штаммы S. aureus, выделенные от пациентов, характеризовались широким спектром факторов патогенности и персистенции. Антилизоцимной активностью обладали 100% исследованных культур, антиинтерфероновой и антикомплементарной, соответственно, 96,0 и 64,0%, способностью к адгезии — 36,0%. Одновременно антилизоцимную, антиинтерфероновую и антикомплементарную активность проявляли 52,0% штаммовS. aureus. Эти данные негативно характеризуют прогнозируемую на ближайшее время региональную тенденцию динамики показателей заболеваемости.

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