Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC154210.15690/vramn1542RHEUMATOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ РЕВМАТОЛОГИИReview ArticleThe Value of Trabecular Bone Score in Patients with Rheumatic DiseasesЗначение трабекулярного костного индекса у больных ревматическими заболеваниямиhttps://orcid.org/0000-0002-6834-2651KolpakovKonstantin I.КолпаковКонстантин Игоревич
Russian Federation
elmad95@mail.ruhttps://orcid.org/0000-0002-4890-08475494-7355KorolevMaxim A.КоролевМаксим Александрович
Russian Federation

MD, PhD, Associate Professor

к.м.н, доцент

kormax@bk.ruhttps://orcid.org/0000-0001-6330-1044UbshaevaYuliya B.УбшаеваЮлия Борисовна
Russian Federation

MD, PhD

к.м.н.

leobina@mail.ruResearch Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesНаучно-исследовательский институт клинической и экспериментальной лимфологии – филиал Института цитологии и генетики Сибирского отделения Российской академии наук221020217644024110904202131082021Copyright ©; 2021, "Paediatrician" Publishers LLCCopyright ©; 2021, Издательство "Педиатръ"2021"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1542

Background. Trabecular bone score obtained by lumbar spine Dual-energy X-ray Absorptiometry is a novel and insufficiently explored instrument of accessing trabecular bone quality. One of its promising applications is early diagnostics of osteoporosis (OP) before fragility fractures appear. Meanwhile most of systemic inflammatory rheumatic diseases affect bone tissue either directly and indirectly by glucocorticoids consumption. Both factors potentiate OP development and can influence the trabecular bone score.

Aims — to evaluate the possibilities of trabecular bone score using in rheumatology.

Materials and Methods. Data analysis of domestic and foreign scientific publications.

Results and Discussion. Authors of analyzed publications note stable association of low trabecular bone score with vertebral fractures, its correlation with local inflammatory markers in lumbar spine and ankylosing spondylitis structural progression. In most studies trabecular bone score do not have association with systemic inflammatory activity and treatment.

Conclusion. Trabecular bone score is effective in OP diagnostics in rheumatic patients, evaluation of local inflammatory activity in the lumbar spine and structural progression of ankylosing spondylitis.

Обоснование. Трабекулярный костный индекс, получаемый при двухэнергетической рентгеновской абсорбциометрии поясничного отдела позвоночника в прямой проекции, является относительно новым и малоизученным инструментом оценки строения трабекулярной костной ткани. Одно из перспективных возможностей его практического применения — ранняя диагностика остеопороза (ОП) до развития патологических переломов. В то же время многие ревматические системные воспалительные заболевания прямо поражают костно-мышечную систему и контролируются глюкокортикоидами. Оба фактора потенцируют развитие ОП и могут вызывать изменение трабекулярного костного индекса.

Цель работы — оценить возможности применения трабекулярного костного индекса у больных ревматическими заболеваниями.

Материалы и методы. Анализ данных отечественной и зарубежной литературы, научных публикаций, электронных ресурсов.

Результаты и обсуждение. Авторы научных публикаций отмечают стабильную ассоциацию низких значений трабекулярного костного индекса у ревматологических пациентов с компрессионными переломами позвонков, его корреляцию с маркерами локального воспаления в позвоночнике и структурного прогрессирования анкилозирующего спондилита. В большинстве исследований трабекулярный костный индекс не показал четкой взаимосвязи с системной воспалительной активностью ревматических заболеваний и принимаемой терапией.

Выводы. Трабекулярный костный индекс эффективен в диагностике остеопороза у пациентов с ревматическими заболеваниями, оценке активности локальной воспалительной реакции и структурного прогрессирования при анкилозирующем спондилите.

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