Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC150710.15690/vramn1507OBSTETRICS AND GYNECOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ АКУШЕРСТВА И ГИНЕКОЛОГИИResearch ArticleImmunological Aspects of Normal and Pathological PregnancyИммунологические аспекты нормальной и патологически протекающей беременностиhttps://orcid.org/0000-0001-7516-520357203807050AAJ-2991-20204757-7940GalkinaDaria E.ГалкинаДарья Евгеньевна
Russian Federation

MD, PhD, Associate Professor

кандидат медицинских наук, доцент кафедры оперативной гинекологии, врач акушер-гинеколог и заведующий хирургическим отделением "Профессорской клиники"

dashsemch@mail.ruhttps://orcid.org/0000-0002-2899-8103AAJ-2216-20203133-7406MakarenkoTatyana A.МакаренкоТатьяна Александровна
Russian Federation

MD, PhD, Associate Professor

доктор медицинских наук, заведующая кафедрой оперативной гинекологии института последипломного образования, доцент

makarenko7777@yandex.ruhttps://orcid.org/0000-0003-3212-79576149514971-5250OkladnikovDmitry V.ОкладниковДмитрий Владимирович
Russian Federation

MD, PhD, Associate Professor

кандидат медицинских наук, доцент кафедры патологической физиологии имени профессора В.В. Иванова

okladdm@yandex.ruKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyКрасноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого1804202277113242001202125032022Copyright ©; 2022, "Paediatrician" Publishers LLCCopyright ©; 2022, Издательство "Педиатръ"2022"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1507

This article presents an overview of foreign and domestic data (Web of Science, e-LIBRARY, Scopus, PubMed) for the period 1998–2021, devoted to the system of immune protection of the mother and fetus during normal and pathologically occurring pregnancy. According to the results of the analysis of the literature data, changes occurring at the level of cellular and humoral immunity were revealed, and the mechanisms of innate and adaptive immunity, complement systems in such pathologies of pregnancy as miscarriage, threat of termination, preeclampsia, infectious complications were described. A complex system of protection against fetal rejection is a certain regulatory factor in maintaining the immunological balance during the entire gestation period, and a violation in its work underlies the formation of complications of the early and late postpartum period, as well as neonatal pathologies.

В данной статье представлен обзор зарубежных и отечественных данных (Web of Science, e-LIBRARY, Scopus, PubMed) за период 1998–2021 гг., посвященных системе иммунной защиты матери и плода во время нормальной и патологически протекающей беременности. По результатам анализа литературных данных были выявлены изменения, происходящие на уровне клеточного и гуморального иммунитета, а также описаны механизмы работы врожденного и адаптивного иммунитета, системы комплемента при таких патологиях беременности, как невынашивание, угроза прерывания, преэклампсия, инфекционные осложнения. Сложно устроенная система защиты от отторжения плода является определенным регулирующим фактором в поддержании иммунологического баланса во время всего периода гестации, а нарушение в его работе лежит в основе формирования осложнений раннего и позднего послеродового периода, а также неонатальных патологий.

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