Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC14810.15690/vramn.v68i9.778SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯPLATELET ACTIVITY IN THE CHRONIC SCHIZOPHRENIC PATIENTS DURING ATTACKS OUTCOME AND REMISSION DEVELOPMENTАКТИВАЦИЯ ТРОМБОЦИТОВ У МУЖЧИН, ХРОНИЧЕСКИ БОЛЬНЫХ ШИЗОФРЕНИЕЙ, В ПРОЦЕССЕ ВЫХОДА ИЗ ПРИСТУПА И ФОРМИРОВАНИЯ РЕМИССИИBrusovO. S.БрусовО. С.
Russian Federation

MD, chief of the clinical biochemistry laboratory of the Federal State Budgetary Institution «Mental Health Research Center» of RAMS. Address: bld. 16, build. 3, 2, Zagorodnoye Route, Moscow, 117152; tel.: (495) 952-91-41

oleg_brusov@mail.ruZlobinaG. P.ЗлобинаГ. П.
Russian Federation

MD, senior research scientist of the clinical biochemistry laboratory of the Federal State Budgetary Institution «Mental Health Research Center» of RAMS. Address: bld. 16, build. 3, 2, Zagorodnoye Route, Moscow, 117152; tel.: (495) 952-91-41

zlobina2000@mail.ruMental Health Research Center of the Russian Academy of Medical Sciences, Moscow, Russian FederationНаучный центр психического здоровья РАМН, Москва, Российская Федерация10092013689Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук424507082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/148

The purpose of this work was to evaluate the degree of activation of platelets chronically schizophrenic patients with paroxysmal course of the disease during outcome from the attack of disease or in process of forming of the remission. Platelets in platelet-rich-plasma (PRP) and after PRP gel-filtration through the column with Sepharose CL-2B taken from the ulnar vein of males with chronic schizophrenia during outcome from the attack of disease or in process of forming of the remission were measured. Patients were investigated on the peak of the disease attack (visit 1), at the stage of significant improvement of clinical state (visit 2), and at the stage of stable drug-induced remission (visit 3). Platelet quantities in PRP prepared by centrifugation are equal in patients in visits 1, 2 or 3. These platelets quantities are much less than similar platelet quantities in healthy individuals matched in age. The additional decreases of platelet quantities were found after the elution of PRP platelets from the column with Sepharose CL-2B. These additional platelet quantity losses are increased from visit 1 to visit 3. Such losses of cells indicate decrease in their resistance to various influences, their activation in spite of remission development in this group of patients.

Цель настоящей работы - оценка степени активации тромбоцитов хронически больных шизофренией с приступообразным течением болезни в процессе выхода из приступа и формирования ремиссии. Оценивали число тромбоцитов в обогащенной тромбоцитами плазме (ОТП) и в элюате после гель-фильтрации ОТП через колонку с сефарозой CL-2B у мужчин, хронически больных шизофренией, в процессе выхода из приступа и формирования ремиссии. Больные были обследованы на высоте приступа (визит 1), на этапе значительного улучшения состояния (визит 2) и на этапе сформированной лекарственной терапии (визит 3). В ОТП, полученной центрифугированием, число тромбоцитов было одинаковым у больных при 1-м, 2-м, 3-м визите и при этом значительно меньше, чем у здоровых доноров. Хроматография тромбоцитов с использованием сефарозы CL-2B продемонстрировала дополнительные потери тромбоцитов больных, при этом потери тромбоцитов возрастали от 1-го к 3-му визиту. Такие потери клеток указывают на снижение их резистентности к различным воздействиям, их активацию, несмотря на формирование ремиссии у больных.

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