Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC14010.15690/vramn.v68i10.789SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯFEATURES OF THE FUNCTIONING OF THE THYROID GLAND IN HIV-INFECTEDОСОБЕННОСТИ ФУНКЦИОНИРОВАНИЯ ЩИТОВИДНОЙ ЖЕЛЕЗЫ У ЛИЦ С ВИЧ-ИНФЕКЦИЕЙTimofeevaE. V.ТимофееваЕ. В.
Russian Federation

PG student of the Federal State Budgetary Institution “Scientific Centre of the Family Health and Human Reproduction Problems” under the Siberian Branch of RAMS. Address: 16, Timiryazeva St., Irkutsk, 664003, tel.: (3952) 20-76-36

eve_gin@list.ruLeshchenkoO. Ya.ЛещенкоО. Я.
Russian Federation

PhD, Head of the socially significant infections laboratory of the Federal State Budgetary Institution “Scientific Centre of the Family Health and Human Reproduction Problems” under the Siberian Branch of RAMS. Address: 16, Timiryazeva St., Irkutsk, 664003, tel.: (3952) 20-76-36

loyairk@mail.ruScientific Center of Family Health and Human Reproduction Siberian Branch of Russian Academy of Medical Sciences, Irkutsk, Russian FederationНаучный центр проблем здоровья семьи и репродукции человека СО РАМН, Иркутск, Российская Федерация101020136810Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук535607082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/140

In the article the current literature, devoted to the peculiarities of functioning of the thyroid gland in patients with HIV infection, is analyzed. Based on the analysis of literature data bases demonstrated the structure of thyroid function disorders in HIV-infected, as well as the mechanisms of the pathogenesis of these disorders. In the structure of thyroid function is dominated by hypothyroidism, euthyroid pathological syndrome, Graves' disease, for which the opportunistic infections are triggers immune activation. It should be noted that the step of acquired immunodeficiency syndrome is accompanied by the development of inflammatory and neoplastic processes in the thyroid gland. Convincingly demonstrated the negative impact of highly active antiretroviral therapy in HIV-positive for the development of thyroid dysfunction, in connection which the expediency of forming risk groups and the timely correction of the projected thyroid diseases.

В статье проведен анализ современных литературных данных, посвященных особенностям функционирования щитовидной железы у лиц с ВИЧ-инфекцией, рассмотрены структура нарушений тиреоидной функции у ВИЧ – инфицированных и механизмы патогенеза этих нарушений. В структуре нарушений функции щитовидной железы преобладают гипотиреоз, эутиреоидный патологический синдром, болезнь Грейвса, для которых оппортунистические инфекции являются триггерами иммунной активации. Отмечено, что стадия синдрома приобретенного иммунодефицита сопровождается развитием воспалительных и неопластических процессов в щитовидной железе. Убедительно доказано негативное влияние высокоактивной антиретровирусной терапии у ВИЧ-инфицированных на развитие тиреоидной дисфункции, в связи с чем показана целесообразность формирования групп риска и своевременная коррекция прогнозируемых заболеваний щитовидной железы.

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