Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC139610.15690/vramn1396ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИReview ArticleVitamin D-binding protein: multifunctional component of blood serumВитамин D-связывающий белок как многофункциональный компонент сыворотки кровиhttps://orcid.org/0000-0002-7634-54571970-2811PovaliaevaAlexandra A.ПоваляеваАлександра Александровна
Russian Federation
a.petrushkina@yandex.ruhttps://orcid.org/0000-0001-6539-466X6912-6331PigarovaEkaterina A.ПигароваЕкатерина Александровна
Russian Federation

MD, PhD

д.м.н.

kpigarova@gmail.comhttps://orcid.org/0000-0001-7112-58963959-5866RomanovaAnastasia A.РомановаАнастасия Александровна
Russian Federation

MD

svetasvetikova1535@gmail.comhttps://orcid.org/0000-0002-0327-46192958-5555DzeranovaLarisa K.ДзерановаЛариса Константиновна
Russian Federation

MD, PhD

д.м.н.

dzeranovalk@yandex.ruhttps://orcid.org/0000-0002-2729-93868513-7785ZhukovArtem Y.ЖуковАртем Юрьевич
Russian Federation

MD

zhukovartem@yahoo.comhttps://orcid.org/0000-0001-7041-07325691-7775RozhinskayaLiudmila Y.РожинскаяЛюдмила Яковлевна
Russian Federation

MD, PhD, Professor

д.м.н., профессор

lrozhinskaya@gmail.comEndocrinology Research CentreНациональный медицинский исследовательский центр эндокринологии120420217611031101307202016022021Copyright ©; 2021, "Paediatrician" Publishers LLCCopyright ©; 2021, Издательство "Педиатръ"2021"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/1396

Vitamin D-binding protein (DBP) was discovered more than half a century ago as a polymorphic serum protein and is currently characterized by a variety of physiological properties. First of all, DBP carries the bulk of vitamin D metabolites circulating in the bloodstream, while albumin is the second most important transport protein, especially in patients with a low concentration of DBP in serum. Since it was discovered that only 1–2% of the total circulating DBP have occupied steroid binding sites, a vigorous study of other potential biological roles of DBP was initiated: actin utilization, regulation of inflammation and innate immunity mechanisms, fatty acid binding, effects on bone metabolism and participation in the tumor pathogenesis. This review focuses on the main known biological functions of DBP.

Витамин D-связывающий белок (DBP) был открыт более полувека назад в качестве полиморфного белка сыворотки крови и к настоящему моменту характеризуется многообразием физиологических свойств. Прежде всего, DBP переносит основную часть циркулирующих в кровотоке метаболитов витамина D, тогда как альбумин является вторым по значимости транспортным белком, особенно у пациентов с низкой концентрацией DBP в сыворотке. Поскольку было открыто, что сайты связывания стероидов заняты лишь у 1–2% от общего количества циркулирующего DBP, инициировано активное изучение других потенциальных биологических ролей этого белка: утилизация актина, регуляция процессов воспаления и механизмов врожденного иммунитета, связывание жирных кислот, влияние на метаболизм костной ткани и связь с патогенезом опухолевых заболеваний. Данный обзор посвящен рассмотрению основных известных биологических функций DBP.

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