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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1313</article-id><article-id pub-id-type="doi">10.15690/vramn1313</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GASTROENTEROLOGY: CURRENT ISSUES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ГАСТРОЭНТЕРОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Cross-Functional Syndrome of Gastrointestinal Diseases in Adults and Children in the Context of Their Continuity</article-title><trans-title-group xml:lang="ru"><trans-title>Синдром перекреста функциональных желудочно-кишечных заболеваний у взрослых и детей в контексте их преемственности</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6114-564X</contrib-id><contrib-id contrib-id-type="scopus">550426</contrib-id><contrib-id contrib-id-type="spin">1994-0933</contrib-id><name-alternatives><name xml:lang="en"><surname>Maev</surname><given-names>Igor' V.</given-names></name><name xml:lang="ru"><surname>Маев</surname><given-names>Игорь Вениаминович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Academician of the RAS</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН</p></bio><email>igormaev@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8417-5849</contrib-id><contrib-id contrib-id-type="scopus">790039</contrib-id><contrib-id contrib-id-type="spin">3373-5500</contrib-id><name-alternatives><name xml:lang="en"><surname>Osadchuk</surname><given-names>Maksim M.</given-names></name><name xml:lang="ru"><surname>Осадчук</surname><given-names>Максим Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>osadchuk_83@bk.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0485-6802</contrib-id><contrib-id contrib-id-type="scopus">671330</contrib-id><contrib-id contrib-id-type="spin">3108-0478</contrib-id><name-alternatives><name xml:lang="en"><surname>Osadchuk</surname><given-names>Mihail A.</given-names></name><name xml:lang="ru"><surname>Осадчук</surname><given-names>Михаил Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>osadchuk.mikhail@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution></aff><aff><institution xml:lang="ru">Московский государственный медико-стоматологический университет имени А.И. Евдокимова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">City Polyclinic No. 52 of the Moscow Department of Health</institution></aff><aff><institution xml:lang="ru">Городская поликлиника № 52</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-11-30" publication-format="electronic"><day>30</day><month>11</month><year>2021</year></pub-date><volume>76</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>458</fpage><lpage>464</lpage><history><date date-type="received" iso-8601-date="2020-03-18"><day>18</day><month>03</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2021-10-06"><day>06</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Издательство "Педиатръ"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2022-11-30"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/1313">https://vestnikramn.spr-journal.ru/jour/article/view/1313</self-uri><abstract xml:lang="en"><p>This review provides an analysis of a possible relationship between functional diseases of the gastrointestinal tract in children and adults. Some functional disorders previously identified only in the children’s age group, such as abdominal migraine, were increasingly recorded in the adult population. As a rule, the diagnosis of functional gastrointestinal diseases is based primarily on clinical symptoms. However, researchers increasingly note that for some pathologies in children, such as gastroesophageal reflux disease, the main symptoms of reflux, such as heartburn and belching, are not absolutely dominant. All this makes it possible to express an opinion on the formation of a universal functional pathology of the digestive tract with the dominance at certain stages of the pathological process of one or another symptomatology that affects the central nervous system.</p></abstract><trans-abstract xml:lang="ru"><p>В данном обзоре приводится анализ возможной связи между функциональными заболеваниями желудочно-кишечного тракта в детской и взрослой популяции. Некоторые функциональные заболевания, ранее определяемые только в детской возрастной группе, такие как абдоминальная мигрень, все чаще стали регистрироваться и у взрослого контингента. Как правило, постановка диагноза функциональных желудочно-кишечных заболеваний базируется преимущественно на клинических симптомах. Однако исследователи все чаще отмечают, что при некоторых патологиях у детей, таких как гастроэзофагеальная рефлюксная болезнь, основные симптомы рефлюкса, например изжога и отрыжка, не носят абсолютно доминирующего характера. Все это дает возможность высказать мнение о формировании универсальной функциональной патологии пищеварительного тракта с доминированием на определенных этапах патологического процесса той или иной симптоматики, затрагивающей и центральную нервную систему.</p></trans-abstract><kwd-group xml:lang="en"><kwd>functional diseases of the gastrointestinal tract</kwd><kwd>chiasm syndrome in children and adults</kwd><kwd>irritable bowel syndrome</kwd><kwd>functional dyspepsia</kwd><kwd>gastroesophageal reflux disease</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>функциональные заболевания желудочно-кишечного тракта</kwd><kwd>синдром перекреста у детей и взрослых</kwd><kwd>синдром раздраженного кишечника</kwd><kwd>функциональная диспепсия</kwd><kwd>гастроэзофагеальная рефлюксная болезнь</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Keely S, Walker MM, Marks E, Talley NJ. 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