Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC118210.15690/vramn1182ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИResearch ArticleDiabetes Mellitus and Thyroid Dysfunction, Including Autoimmune Genesis. Mutual Influence of PathologiesСахарный диабет и дисфункция щитовидной железы, в том числе аутоиммунного генеза. Взаимное влияние патологийhttps://orcid.org/0000-0001-5917-68698825-8874TkachukA. V.ТкачукА. В.
Russian Federation

MD, Clinical Resident

врач-эндокринолог, клинический ординатор

arinatarasova@inbox.ruhttps://orcid.org/0000-0002-4382-05143172-5538MikhinaM. S.МихинаМ. С.
Russian Federation

MD, Research Associate

врач-эндокринолог, н.с.

docmikhina@mail.ruhttps://orcid.org/0000-0003-3535-520X5013-8222IbragimovaL. I.ИбрагимоваЛ. И.
Russian Federation

MD, PhD, Leading Research Associate

к.м.н., в.н.с.

ibragimovaliudmila@gmail.comhttps://orcid.org/0000-0001-5656-25968863-0201NikonovaT. V.НиконоваТ. В.
Russian Federation

MD, PhD

д.м.н.

tatiana_nikonova@mail.ruhttps://orcid.org/0000-0002-8520-87028821-8990TroshinaE. A.ТрошинаЕ. А.
Russian Federation

MD, PhD, Professor, Corresponding Member of the RAS

д.м.н., профессор, член-корреспондент РАН

troshina@inbox.ruEndocrinology Research CentreНациональный медицинский исследовательский центр эндокринологии151220207566476521408201908122020Copyright ©; 2020, "Paediatrician" Publishers LLCCopyright ©; 2020, Издательство "Педиатръ"2020"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1182

Thyroid disease, including autoimmune genesis, and diabetes mellitus are the two most common endocrine diseases in clinical practice. These pathologies have a mutual influence on each other. On the one hand, thyroid hormones are involved in regulation of carbohydrate metabolism: excessive production of thyroid hormones is associated with hyperglycemia, while hypothyroidism has a decreased level of glucose production by the liver. On the other hand, glucose homeostasis disorder affects the functional state of the thyroid gland: dystrophic, sclerotic and atrophic processes are developing in thyroid gland, what is a manifestation of diabetic microangiopathy. This article demonstrates the need to take into account the mutual influence of pathologies for optimal treatment of this conditions.

Заболевания щитовидной железы, в том числе аутоиммунного генеза, и сахарный диабет являются двумя наиболее распространенными эндокринными нарушениями, встречающимися в клинической практике. Данные патологии оказывают взаимное влияние друг на друга. С одной стороны, гормоны щитовидной железы участвуют в регуляции углеводного обмена: избыточная продукция тиреоидных гормонов ассоциирована с гипергликемией, в то время как при гипотиреозе наблюдается сниженный уровень продукции глюкозы печенью. С другой стороны, нарушение в гомеостазе глюкозы воздействует на функциональное состояние щитовидной железы: в органе развиваются дистрофические, склеротические и атрофические процессы, что представляет собой проявление диабетической микроангиопатии. Данная статья демонстрирует необходимость учета взаимного влияния патологий для оптимального лечения этих состояний.

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