Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC118110.15690/vramn1181Research ArticlePredictive biomarkers in the treatment of acromegaly: a review of the literaturePrzhiyalkovskayaE. G.<p>MD, PhD</p>przhiyalkovskaya.elena@gmail.comhttps://orcid.org/0000-0001-9119-2447OsmanovaPatimat O.osmanova.ne@yandex.ruhttps://orcid.org/0000-0003-0473-8144MamedovaElizaveta O.<p>MD, PhD</p>lilybet@mail.ruhttps://orcid.org/0000-0002-9783-3599LutsenkoAlexander S.some91@mail.ruhttps://orcid.org/0000-0002-9314-7831BelayaZhanna E.<p>MD, PhD</p>jannabelaya@gmail.comhttps://orcid.org/0000-0002-6674-6441MelnichenkoGalina A.<p>MD, PhD, Professor</p>Teofrast2000@mail.ruhttps://orcid.org/0000-0002-5634-7877Endocrinology Research Centre211220197464304402509201909122019Copyright © 2019, "Paediatrician" Publishers LLC2019<p>In the era of personalized medicine treatment of acromegaly requires the individual selection of optimal treatment based on the measured parameters. Following the standard algorithm for the management of patients with acromegaly with the choice of neurosurgical treatment as the main and somatostatin analogues as the first line of drug therapy with ineffective surgery prevents the achievement of remission in patients resistant to these types of therapy. The introduction of predictive biomarkers in clinical practice will allow to achieve remission of the disease faster and reduce the financial costs of ineffective treatments. We collected information of possible predictive biomarkers in acromegaly from literature. This review presents data from studies of potential predictive biomarkers in different treatments of acromegaly. According to the analysis of publications, the greatest number of results is devoted to the prediction resistance to somatostatin analogues. Reliable biomarkers predicting the inefficiency of somatostatin analogues include low immunoexpression of somatostatin receptors type 2 and AIP protein, rarely granular type of pituitary adenoma and hyperintensive signal on T2-weighted images in magnetic resonance imaging of the pituitary gland. At the same time, the search for predictors of the effectiveness of pegvisomant is focused on the study of the receptor of growth hormone and opens up new opportunities for pharmacogenomic research. Thus, it is necessary to expand the search of predictive biomarkers for different methods of acromegalys treatment. It is especially important to identify biomarkers that do not require mandatory removal of the tumor. Of great interest is the study of epigenetic biomarkers, in particular miRNAs, which carry out post-transcriptional regulation of gene expression. 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