Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC117110.15690/vramn1171OBSTETRICS AND GYNECOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ АКУШЕРСТВА И ГИНЕКОЛОГИИResearch ArticlePossibilities of application of regenerative technologies in gynecologyСовременные аспекты использования клеточных технологий в гинекологииhttps://orcid.org/0000-0003-1753-0537DenisovaJulia V.ДенисоваЮлия Вадимовна
Russian Federation

4th year student of the Medicine of the Future International School

студентка 4-го курса Международной школы «Медицина будущего»

yuliya.sheveleva.97@mail.ruhttps://orcid.org/0000-0002-5397-9422MandraEkaterina V.МандраЕкатерина Владимировна
Russian Federation

4th year student of the Medicine of the Future International School

студентка 4-го курса Международной школы «Медицина будущего»

emandra97@mail.ruhttps://orcid.org/0000-0002-0102-54914954-3004LyundupAleksey V.ЛюндупАлексей Валерьевич
Russian Federation

MD, PhD

к.м.н.

lyundup@gmail.comhttps://orcid.org/0000-0001-7702-26877529-5005SulinaYana Y.СулинаЯна Юрьевна
Russian Federation

MD, PhD

к.м.н.

ya.suli.na@gmail.comhttps://orcid.org/0000-0003-2512-57852738-9662AleksandrovLeonid S.АлександровЛеонид Семёнович
Russian Federation

MD, PhD, Professor

д.м.н., профессор

leonid.aleks@bk.ruhttps://orcid.org/0000-0002-4476-49722306-4571IschenkoАnton А.ИщенкоАнтон Анатольевич
Russian Federation

MD, PhD

к.м.н.

ra2001_2001@mail.ruhttps://orcid.org/0000-0003-3338-11133294-3251IschenkoАnatoliy I.ИщенкоАнатолий Иванович
Russian Federation

MD, PhD, Professor

д.м.н., профессор

liubella.2011@mail.ruhttps://orcid.org/0000-0002-0210-45705940-7554BeregovykhValery V.БереговыхВалерий Васильевич
Russian Federation

PhD, Professor

д.тех.н., профессор, академик РАН

beregovykh@ramn.ruI.M. Sechenov First Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)16032020300320207514172307201923102019Copyright ©; 2020, "Paediatrician" Publishers LLCCopyright ©; 2020, Издательство "Педиатръ"2020"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1171

The article presents a review of publications devoted to the use of regenerative technologies in the treatment of gynecological pathologies. The authors describe possible ways to solve these problems by analyzing the experimental studies conducted in the world. Identified the main indications for tissue engineering: Asherman’s syndrome, primary ovarian failure, infertility caused by chemotherapy, a “niche” in the uterus, endometrial pathology (endometriosis, endometrial problems, etc.), cervical pathology, female genital tract abnormalities, pelvic organ prolapse. The results of clinical trials of cell therapy aimed at treating infertility caused by Asherman syndrome and primary ovarian failure, female genital tract abnormalities, as well as such rare pathology as a “niche” of the uterus. At the preclinical stage, in addition to the above, considered cellular therapy of cervical pathologies, endometrial diseases and pelvic organ prolapse. Eximined cell cultures and the level of their influence on the regeneration of the female reproductive system structures, presented the biological scaffolds that stimulate the growth of stem cells, their effectiveness and shortcomings are covered.

В предлагаемом систематическом обзоре представлен анализ данных клинических и доклинических исследований в области гинекологии, в которых применяли клеточные технологии. Определены основные показания для применения тканеинженерных конструкций: синдром Ашермана, первичная яичниковая недостаточность, бесплодие, несостоятельность рубца на матке, патологии эндометрия (эндометриоз, проблемы эндометрия и др.), патологии шейки матки, аномалии развития женской половой сферы, пролапс тазовых органов. На данный момент описаны результаты клинических испытаний клеточной терапии, направленной на лечение бесплодия при синдроме Ашермана и первичной яичниковой недостаточности, врожденных аномалиях женской половой сферы, а также при такой редкой патологии, как несостоятельность рубца на матке. На доклинической стадии помимо вышеперечисленных рассматривается клеточная терапия патологий шейки матки, заболеваний эндометрия и пролапса тазовых органов. Представлены клеточные культуры и уровень их воздействия на процессы регенерации структур половой системы женщины, рассмотрены биологические матрицы, стимулирующие рост стволовых клеток, их эффективность и недостатки. В настоящее время в России появилась нормативно-правовая база для внедрения в клиническую практику новых средств лечения с использованием живых клеток человека.

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