Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC1160210.15690/vramn11602DERMATOLOGY and VENEROLOGY: current issuesАКТУАЛЬНЫЕ ВОПРОСЫ ДЕРМАТОВЕНЕРОЛОГИИReview ArticleSarcoidosis of the Skin as an Interdisciplinary ProblemСаркоидоз кожи как междисциплинарная проблемаhttps://orcid.org/0000-0002-9458-08722287-5062SamtsovAlexey V.СамцовАлексей Викторович
Russian Federation

MD, PhD, Professor

доктор медицинских наук, профессор

avsamtsov@mail.ruhttps://orcid.org/0000-0002-8396-19363900-3441KryukovEvgeniy V.КрюковЕвгений Владимирович
Russian Federation

MD, PhD, Professor, Academician of the RAS

доктор медицинских наук , профессор, академик РАН

evgeniy.md@mail.ruS.M. Kirov Military Medical AcademyВоенно-медицинская академия имени С.М. Кирова150120247915141605202301122023Copyright ©; 2024, "Paediatrician" Publishers LLCCopyright ©; 2024, Издательство "Педиатръ"2024"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/11602

Sarcoidosis is a disease of unknown etiology characterized by the formation of epithelioid cell granulomas in several organs or tissues without caseous necrosis (fibrinoid necrosis may occur). With sarcoidosis, almost all organs and tissues can be affected, which determines the interdisciplinary nature of the problem. Skin sarcoidosis is one of the most common manifestations of systemic sarcoidosis. At the same time, the role of dermatologists in the diagnosis of sarcoidosis is exceptionally large, since skin lesions are often the key to the discovery of systemic sarcoidosis, which allows internists to purposefully and timely diagnose and treat lesions of internal organs. Skin rashes in patients with sarcoidosis may occur secondarily against the background of specific lesions of the lungs, intrathoracic nodes and other internal organs, however, skin sarcoidosis may also develop primarily. All forms of skin sarcoidosis may be the only manifestation of the disease, and it is impossible to distinguish clinically and histologically between skin changes in systemic sarcoidosis and skin lesions alone. Treatment of skin sarcoidosis often presents great difficulties and includes, depending on the prevalence and activity of the process, local (corticosteroids, tacrolimus) and systemic therapy (immunomodulators, immunosuppressors, TNF inhibitors).

Саркоидоз — заболевание неизвестной этиологии, характеризующееся образованием в нескольких органах или тканях эпителиоидно-клеточных гранулем без казеозного некроза (может встречаться фибриноидный некроз). При саркоидозе возможно поражение практически всех органов и тканей, что определяет междисциплинарный характер проблемы. Cаркоидоз кожи представляет собой одно из наиболее частых проявлений системного саркоидоза. При этом роль дерматологов в диагностике саркоидоза исключительно велика, поскольку поражения кожи нередко бывают ключом к открытию системного саркоидоза, что позволяет интернистам целенаправленно и своевременно диагностировать и проводить лечение поражений внутренних органов. Высыпания на коже у больных саркоидозом могут возникать вторично на фоне специфических поражений легких, внутригрудных узлов и других внутренних органов, однако саркоидоз кожи может развиться и первично. Все формы саркоидоза кожи могут быть единственным проявлением заболевания, и различить клинически и гистологически изменения кожи при системном саркоидозе и поражении только кожи невозможно. Лечение саркоидоза кожи нередко представляет большие трудности и включает в зависимости от распространенности и активности процесса местную (кортикостероиды, такролимус) и системную (иммуномодуляторы, иммуносупрессоры, ингибиторы ФНО) терапию.

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