Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC11610.15690/vramn.v68i11.837OBSTETRICS AND GYNAECOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ АКУШЕРСТВА И ГИНЕКОЛОГИИCELLS OF IMMUNE SYSTEM OF MOTHER АND TROPHOBLAST CELLS: CONSTRUCTIVE COOPERATION FOR THE SAKE OF ACHIEVEMENT OF THE JOINT PURPOSEКЛЕТКИ ИММУННОЙ СИСТЕМЫ МАТЕРИ И КЛЕТКИ ТРОФОБЛАСТА: «КОНСТРУКТИВНОЕ СОТРУДНИЧЕСТВО» РАДИ ДОСТИЖЕНИЯ СОВМЕСТНОЙ ЦЕЛИAilamazyanE. K.АйламазянЭ. К.
Russian Federation

PhD, professor, academician of RAMS, Honoured scientist of Russian Federation, Director of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 325-32-20

iag@ott.ruStepanovaO. I.СтепановаО. И.
Russian Federation

MD, research scientist of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45

alzas@mail.ruSel'kovS. A.СельковС. А.
Russian Federation

PhD, professor, Head of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45

elkovsa@mail.ruSokolovD. I.СоколовД. И.
Russian Federation

PhD, leading research scientist of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45, (812) 328-98-50

falcojugger@yandex.ruD.O. Ott Research Institute of Obstetrics and Gynecology North-West Branch under the Russian Academy of Medical Sciences, St. Petersburg, Russian FederationНИИ акушерства и гинекологии им. Д.О. Отта СЗО РАМН, Санкт-Петербург, Российская Федерация121120136811Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук122107082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/116

In the present review modern data about change of morfo-functional properties of a trophoblast during pregnancy, and also about influence of the cytokines produced by cells of a microenvironment, including leucocytes of mother, on a functional state of trophoblast is cited. Features of interaction between trophoblast and immune cells of mother are described within physiological pregnancy and within pregnancy complicated by preeclampsia.

В обзоре приведены современные данные об изменении морфофункциональных свойств трофобласта в течение беременности, влиянии цитокинов, продуцируемых клетками микроокружения, в т.ч. лейкоцитами матери, на функциональное состояние трофобласта, описаны особенности взаимодействия трофобласта с клетками иммунной системы матери при физиологической беременности и при беременности, осложненной преэклампсией. Работа поддержана грантом Президента РФ № НШ-131.2012.7, грантом РФФИ № 13-04-00304 А.

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