Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC114010.15690/vramn1140CARDIOLOGY AND CARDIOVASCULAR SURGERY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИ И СЕРДЕЧНО-СОСУДИСТОЙ ХИРУРГИИResearch ArticleFeatures of Takotsubo Syndrome in Male PatientsОсобенности синдрома Такоцубо у мужчинhttps://orcid.org/0000-0002-6547-13945577-7982KaraoglanovaTat’yana E.КараоглановаТатьяна Эдуардовна
Russian Federation

MD, PhD, Associate Professor

к.м.н., доцент

t.e.kar@mail.ruhttps://orcid.org/0000-0003-4087-33519044-6712ManzyukAleksey V.МанзюкАлексей Васильевич
Russian Federation

Student

студент

aleksej-manzyuk@yandex.ruI.M. Sechenov First Moscow State Medical University (Sechenovskiy University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)071220207555085131205201918102020Copyright ©; 2020, "Paediatrician" Publishers LLCCopyright ©; 2020, Издательство "Педиатръ"2020"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1140

Takotsubo syndrome has particular significance among heart diseases, as with the increase in the number of publications, there is more and more evidence that this syndrome can cause serious complications and even death of patients. Similarity with acute coronary syndrome is even more important reason for interest in Takotsubo syndrome, coupled with the lack of a clear diagnostic criterion to distinguish these pathologies. The lack of understanding of the pathogenesis of Takotsubo syndrome is one of the obstacles to the formation of such a diagnostic criterion. Despite a large number of publications on the causes and pathogenesis of Takotsubo syndrome, course of the disease has not been studied in men, since this pathology is much more often observed in women. Identifying the gender characteristics of this disease and their causes can be an important step towards explaining the pathogenesis of Takotsubo syndrome. In this review, a sample of 45 clinical cases of Takotsubo syndrome in men was compared with a mixed group from a clinical study. Takotsubo syndrome in men has a number of distinctive features: the greater importance of physical stress in the structure of the causes, in contrast to the predominance of emotional stress in the mixed group, a higher proportion of the basal form of the disease, as well as a significant decrease in the ejection fraction of the left ventricle and the frequent occurrence of cardiogenic shock manifestations of a more severe course of this disease.

Синдром Такоцубо имеет особенное значение среди заболеваний сердца, так как с ростом числа публикаций, появляется все больше подтверждений тому, что данный синдром может стать причиной серьезных осложнений и даже смерти пациентов. Но более важная причина интереса к синдрому Такоцубо — его схожесть с острым коронарным синдромом в совокупности с отсутствием четкого диагностического критерия, позволяющего отличать эти патологии. Отсутствие понимания патогенеза синдрома Такоцубо является одним из препятствий к формированию такого диагностического критерия. Несмотря на большое количество публикаций о причинах и патогенезе синдрома Такоцубо, практически не изучалось его течение у мужчин, так как данная патология значительно чаще наблюдается у женщин. Выявление гендерных особенностей данного заболевания и их причин может быть важным шагом на пути к объяснению патогенеза синдрома Такоцубо. В данном обзоре выборка из 45 клинических случаев синдрома Такоцубо у мужчин сравнивалась со смешанной группой из клинического исследования. Синдром Такоцубо у мужчин имеет ряд отличительных особенностей: большее значение физического стресса в структуре причин возникновения, в отличие от преобладания эмоционального стресса в смешанной группе, более высокая доля базальной формы заболевания, а также значительное снижение фракции выброса левого желудочка и частое возникновение кардиогенного шока как проявления более тяжелого течения данного заболевания.

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