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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">106</article-id><article-id pub-id-type="doi">10.15690/vramn.v68i12.858</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PEDIATRICS: CURRENT ISSUES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ПЕДИАТРИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">CORTISOL LEVELS IN CORD BLOOD WITH VARIOUS VIOLATIONS OF NEONATAL ADAPTATION</article-title><trans-title-group xml:lang="ru"><trans-title>СОДЕРЖАНИЕ КОРТИЗОЛА В ПУПОВИННОЙ КРОВИ ПРИ РАЗЛИЧНЫХ НАРУШЕНИЯХ АДАПТАЦИИ НОВОРОЖДЕННЫХ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kolesnikova</surname><given-names>N. I.</given-names></name><name xml:lang="ru"><surname>Колесникова</surname><given-names>Л. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, professor, corresponding member of RAMS, Director of Scientific Center of Family Health Aspects and Human Reproduction of Siberian Department of RAMS. Address: 16, Timiryazev Street, Irkutsk, RF, 664003; tel.: +7 (3952) 20-76-36</p></bio><email>iphr@sbamsr.irk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Попова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Head of Gynecology Department № 2 of Municipal Heaslthcare Institution № 6 of Chelyabinsk. Address: 28, Rumyantsev Street, Chelyabinsk, RF, 454047; tel.: +7 (351) 721-25-65</p></bio><email>biochem2009@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinitskii</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Синицкий</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, senior lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76</p></bio><email>biochem2009@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozochkin</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Козочкин</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76</p></bio><email>biochem2009@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gornostaeva</surname><given-names>A. B.</given-names></name><name xml:lang="ru"><surname>Горностаева</surname><given-names>А. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, senior lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76</p></bio><email>biochem2009@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Centre for Problems of Family Health and Human Reproduction of Siberian Branch of RAMS, Chelyabinsk, Russian Federation</institution></aff><aff><institution xml:lang="ru">Научный центр проблем здоровья семьи и репродукции человека СО РАМН, Иркутск, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Chelyabinsk city hospital № 6, Russian Federation</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница № 6, Челябинск, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">South Ural State Medical University, Chelyabinsk, Russian Federation</institution></aff><aff><institution xml:lang="ru">Южно-Уральский государственный медицинский университет, Челябинск, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-12-10" publication-format="electronic"><day>10</day><month>12</month><year>2013</year></pub-date><volume>68</volume><issue>12</issue><issue-title xml:lang="en">Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciences</issue-title><issue-title xml:lang="ru">Вестник Российской академии медицинских наук</issue-title><fpage>41</fpage><lpage>43</lpage><history><date date-type="received" iso-8601-date="2015-08-07"><day>07</day><month>08</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, Издательство "Педиатръ"</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/106">https://vestnikramn.spr-journal.ru/jour/article/view/106</self-uri><abstract xml:lang="en"><p><italic>Shifting extra uterine existence is a serious test of maturity of all functional systems of the newborn , so in recent years, the more attention is payed for the adaptation of the newborn. It is known that the pathological course of pregnancy is a violation of the functional state of the adrenal cortex, and prolonged exposure of the pathological factor leads to the inhibition of adrenocortical function and a decrease of the adaptive capabilities of a newborn. Therefore, serum cortisol levels could be a predictor of complications in preterm infants. Based on this, it seems appropriate to study changes in the content of serum cortisol cord blood prior to the development of various syndromes neonatal maladjustment. The clinical and laboratory examination of term infants with various disorders of adaptation: regurgitation, pain, hyperexcitability , depression , cardio - respiratory depression, bleeding in the skin , toxic erythema. It is shown that the most prominent violations maladjustment processes occur on the background of decreased cortisol. Border states, which are formed on the background of normal or elevated cortisol, are not accompanied by significant impairments of adaptation processes . On the basis of the data was drawn a conclusion about the possibility of using changes of cortisol in cord blood as a reliable indicator of neonatal adaptation processes, pointing to the possibility of the development of pathological conditions.</italic></p><p> </p></abstract><trans-abstract xml:lang="ru"><p><italic>Переход во внеутробное существование является серьезным испытанием зрелости всех функциональных систем новорожденного, поэтому в последние годы вопросам адаптации новорожденных уделяют все больше внимания. Известно, что при патологическом течении беременности</italic><italic> </italic><italic>происходит нарушение функционального состояния коры надпочечников, а длительное воздействие патологического фактора приводит к угнетению функции коры надпочечников и снижению адаптивных возможностей организма новорожденного</italic><italic>.</italic><italic> </italic><italic>Поэтому</italic><italic> сывороточный уровень кортизола может оказаться предиктором осложнений у глубоко</italic><italic> </italic><italic>недоношенных новорожденных</italic><italic>. Исходя из этого, представляется целесообразным исследование изменений содержания кортизола в сыворотке пуповинной крови, предшествующих развитию различных синдромов дезадаптации новорожденных.</italic><italic> </italic><italic> </italic><italic>Проведено клинико-лабораторное обследование доношенных новорожденных с различными нарушениями адаптации: срыгивания, болевой синдром, гипервозбудимость, угнетение, кардио - респираторная депрессия, кровоизлияния в кожу, токсическая эритема. Показано, что наиболее выраженные нарушения процессов дезадаптации протекают на фоне сниженного содержания кортизола. Пограничные состояния, формирующиеся на фоне нормального или повышенного </italic><italic>содержания </italic><italic>кортизола, не сопровождаются значительными нарушениями процессов адаптации. На основании полученных данных сделан вывод о возможности использования изменени</italic><italic>я</italic><italic> </italic><italic>содержания</italic><italic> кортизола в пуповинной крови как надежного показателя процессов адаптации новорожденных, указывающего на возможность развития патологических состояний.</italic></p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>adjustment disorders infants</kwd><kwd>cortisol</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>нарушения адаптации новорожденных</kwd><kwd>кортизол</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	Baranov A.A. The health status of children in the Russian Federation. Pediatriya = Pediatrics. 2012; 91(3): 9–14.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2.	Chervakova T.V., Tokhiyan A.A. The successes of the national obstetrics (based on the defense and confirmation of the WAC's thesis). 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