Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC10510.15690/vramn.v68i12.857PEDIATRICS: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПЕДИАТРИИCHANGES OF EPIDERMAL GROWTH FACTOR LEVEL IN BLOOD SERUM, SALIVA AND GASTRIC JUICE IN CHILDREN WITH DUODENAL ULCERИЗМЕНЕНИЯ ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА В СЫВОРОТКЕ КРОВИ, СЛЮНЕ И ЖЕЛУДОЧНОМ СОКЕ ПРИ ЯЗВЕННОЙ БОЛЕЗНИ 12-ПЕРСТНОЙ КИШКИ У ДЕТЕЙZhukovaE. A.ЖуковаЕ. А.
Russian Federation

PhD, Deputy Director for Research work of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-62-46

zhulenn@mail.ruVidmanovaT. A.ВидмановаТ. А.
Russian Federation

MD, Head of Clinic of Upper Parts of Digestive Tract Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90

talev2001@mail.ruViskovaI. N.ВисковаИ. Н.
Russian Federation

postgraduate student of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90

niidg@mail.ruKolesovS. A.КолесовС. А.
Russian Federation

MD, senior research scientist of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-54-60

niidg@mail.ruKorkotashviliL. V.КоркоташвилиЛ. В.
Russian Federation

MD, Head of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-54-60

lvkor@inbox.ruShirokovaN. Yu.ШироковаН. Ю.
Russian Federation

MD, senior research scientist of Morphology Group of the Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-93-39

niidg@mail.ruKan'kovaN. Yu.КаньковаН. Ю.
Russian Federation

MD, research scientist of Clinic of Upper Parts of Digestive Tract Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90

nelly.kankova@gmail.comFederal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, RussiaФГБУ «Нижегородский научно-исследовательский институт детской гастроэнтерологии» Минздрава России, г. Нижний Новгород, Россия.101220136812Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук364007082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/105

92 children, age 8-17 years, with duodenum ulcer were under observation. The peculiarities of EGF level changes in human biological mediums, depending on phase of the disease. The highest EGF level was detected with acute peptic ulcer in the presence of ulcerous defects. EGF level increasing was marked out in the remission phases ulcerous defects healing, and it didn`t reach normal values in gastric juice. EGF content changes in biological mediums were revealed with different variants of duodenum ulcer clinical course in children. The lowest EGF level was marked out in blood, saliva and gastric juice with unfavorable course of the disease (frequent relapses, cicatricial-ulcerous strains formation), which can serve as a prognostic factor.

Под наблюдением находилось 92 ребенка с язвенной болезнью 12-перстной кишки в возрасте от 8 до 17 лет. Выявлены особенности изменений уровня эпидермального фактора роста (ЭФР) в биосредах организма в зависимости от фазы заболевания. При обострении язвенной болезни (при наличии язвенных дефектов слизистой оболочки двенадцатиперстной кишки) регистрировались наиболее высокие показатели ЭФР, в фазу ремиссии (по мере заживления язвенных дефектов слизистой) отмечалось снижение данного ростового фактора, при этом в желудочном соке он не достигал нормальных значений. Установлены отличия содержания ЭФР в биосредах организма при различных вариантах течения язвенной болезни 12-перстной кишки у детей. При неблагоприятном течении заболевания (частых рецидивах, формировании рубцово-язвенной деформации) отмечалось самое низкое содержание ЭФР как в крови, так и в желудочном соке и слюне, что может служить прогностическим критерием.

duodenal ulcerchildrenepidermal growth factorязвенная болезньдетиэпидермальный фактор роста1. Maev I.V., Kucheryavyi Yu.A., Oganesyan T.S. Ross. zhurn. gastroenterol., gepatol., koloproktol = Russian journal of gastroenterology, hepatology and coloproctology. 2008; 5: 4–11.2. Chen A, Li CN, Hsu PI, [et al.] Risks of interleykin-1 genetic polymorphisms and Helicobacter pylori infection in the development of gastric cancer. Aliment Pharmacol Ther. 2004;20(2):203-11.3. Furuta T, El-Omar EM, Xiao F [et al.] Interleykin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology. 2002;123(1):92-105.4. Playford R.Y., Ghosh S. Cytokines and growth modulators in intestinal inflammation and repair. J Pathol. 2005;205(4):417-25.5. Tsaregorodtseva T.M., Serova T.I. Tsitokiny v gastroenterologii [Cytokines in Gastroenterology]. Moscow, Аnarkhasis, 2003. 96 p.6. Aruin L.I., Kapuller L.L., Isakov V.A. Morfologicheskaya diagnostika boleznei zheludka i kishechnika [Morphological Diagnostics of Stomach and Intestine Diseases]. Moscow, Triada-X, 1998. 496 p.7. Bondarenko O.Yu., Kogan E.A., Sklyanskaya O.A., Lapina T.L., Ivashkin V.T. Ross. zhurn. gastroenterol., gepatol., koloproktol. = Russian journal of gastroenterology, hepatology and coloproctology. 2003; 6: 27–32.8. Kononov A.V. Ross. zhurn. gastroenterol., gepatol., koloproktol = Russian journal of gastroenterology, hepatology and coloproctology. 2006; 3: 12–16.9. Maev I.V., V'yuchnova E.S. Diagnostika i lechenie yazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki: Uch. pos [Diagnostics and Treatment of Stomach and Duodenum Ulcerous Disease: Manual]. Moscow, GOU VUNMTS MZ RF, 2003. 96 p.10. Konturek P.C. Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H.pylori derived gastrotoxins. J. Physiol. Pharmacol. 1997;48(1):3-42.11. Bolezni organov pishchevareniya u detei: Ruk-vo dlya vrachei. Pod red. A.V. Mazurina [Diseases of Digestive Organs in Children: Guideline for Doctors. Edited by A.V. Mazurin]. Moscow, Meditsina, 1984. 656 p.12. Khronicheskii gastroduodenit i yazvennaya bolezn' u detei (diagnostika, terapiya, prognoz, profilaktika). Pod red. A.I. Volkova, E.I. Shabuninoi [Chronic Gastroduodenitis and Ulcerous Disease in Children (Diagnostics, Therapy, Prognosis and Prophylaxis). Edited by A.I. Volkov, E.A. Shabunina]. Nizhnii Novgorod, 2009. 99 p.13. Milani S., Calabro A. Role of growth factors and their receptors in gastric ulcer healing. Microsc. Res. Tech. 2001; 53 (5): 360–371.14. Chao J.C., Liu K.Y., Chen S.H., Fang C.L., Tsao C.W. Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer. World J. Gastroenterol. 2003; 9 (10): 2261–2265.15. Konturek P.C., Bobrzynski A., Konturek S.J., Bielanski W., Faller G., Kirchner T., Hahn E.G. Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. Gut. 1997; 40 (4): 463.