Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC103110.15690/vramn1031CELL TRANSPLANTOLOGY AND TISSUE ENGINEERING: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КЛЕТОЧНОЙ ТРАНСПЛАНТОЛОГИИ И ТКАНЕВОЙ ИНЖЕНЕРИИMicrovesicles of leukocyte originМикровезикулы лейкоцитарного происхожденияhttps://orcid.org/0000-0003-2748-3543MarkovaKseniya L.МарковаКсения Львовна
Russian Federation

Junior research, Cell Interactions Laboratory, Department of Immunology and Cell Interactions.

Saint-Petersburg

SPIN ID: 4917-8153

Младший научный сотрудник лаборатории межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий.

Санкт-Петербург

SPIN-код: 4917-8153

kseniyabelyakova129@gmail.comhttps://orcid.org/0000-0002-7351-6900KoganIgor U.КоганИгорь Юрьевич
Russian Federation

Professor, MD, corresponding member of the RAS, temporarily assuming the responsibilities of the director.

Saint-Petersburg

SPIN-код: 6572-6450

Доктор медицинских наук, профессор, член-корреспондент РАН, временно исполняющий обязанности директора.

Санкт-Петербург

SPIN-код: 6572-6450

ikogan@mail.ruhttps://orcid.org/0000-0003-2126-880XShevelevaAnastasia R.ШевелеваАнастасия Романовна
Russian Federation

Researcher, Cell Interactions Laboratory, Department of Immunology and Cell Interactions.

Saint-Petersburg

SPIN ID:1741-9092

Лаборант-исследователь лаборатории межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий.

Санкт-Петербург

SPIN-код:1741-9092

anastasiasheveleva075@gmail.comhttps://orcid.org/0000-0003-1328-8157MikhailovaValentina A.МихайловаВалентина Анатольевна
Russian Federation

Senior researcher, Cell Interactions Laboratory, Department of Immunology and Cell Interactions, PhD.

SPINID: 1749-5100

Saint-Petersburg

Кандидат биологических наук, старший научный сотрудник лаборатории межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий.

Санкт-Петербург

SPIN-код: 1749-5100

mva_spb@mail.ruhttps://orcid.org/0000-0003-1560-7529SelkovSergey A.СельковСергей Алексеевич
Russian Federation

Professor, MD, Head of Immunology and Cell Interactions Department.

Saint-Petersburg

SPIN ID: 7665-0594

Доктор медицинских наук, профессор, руководитель отдела иммунологии и межклеточных взаимодействий.

Санкт-Петербург

SPIN-код: 7665-0594

selkovsa@mail.ruhttps://orcid.org/0000-0002-5749-2531SokolovDmitry I.СоколовДмитрий Игоревич
Russian Federation

Doctor of Biological Sciences, Head of Cell Interactions Laboratory.

3, Mendeleyevskaya line, 199034 Saint-Petersburg

SPIN ID: 3746-0000

Доктор биологических наук, заведующий лабораторией межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий.

199034, Санкт-Петербург, Менделеевская линия, д. 3

SPIN-код: 3746-0000

falcojugger@yandex.ruThe Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. OttНаучно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта281220187363783870609201801122018Copyright ©; 2018, "Paediatrician" Publishers LLCCopyright ©; 2018, Издательство "Педиатръ"2018"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/1031

Microvesicles are a new field of biological research. They are subcellular structures ranging in size from 100 to 1000 nm and found in practically all human biological fluids. Their sources are different cells. Microvesicles have a diverse internal composition and carry a wide spectrum of molecules on their surface, which determines their participation in physiological and pathological processes. Their assumed role of biological markers of diseases has aroused great interest. At the present time, there is a lot of data in the world literature about microvesicles of platelets and endothelial cells, and there is practically no data about microvesicles of leukocytes. In this regard, the purpose of the given review was to summarize the data about microvesicles of leukocytes. The review presents data about source cells, internal and superficial composition of leukocytes’ microvesicles, their interaction with various cells, and involvement in physiological and pathological processes. Further study of microvesicles will make it possible to clarify their role in normal and pathological conditions, the possibility of using them as vectors of diseases and carriers of various biologically active molecules.

Микровезикулы ― новый объект биологических исследований. Они представляют собой субклеточные структуры размером от 100 до 1000 нм и обнаружены практически во всех биологических жидкостях человека. Их источниками являются различные клетки организма. Микровезикулы обладают разнообразным внутренним составом и несут широкий спектр молекул на своей поверхности, что определяет их участие в физиологических и патологических процессах. Предполагается их роль в качестве биологических маркеров заболеваний, чем и обусловлен интерес к ним. В настоящее время в мировой литературе достаточно много данных o микровезикулах тромбоцитов и эндотелиальных клеток, при этом данных o микровезикулах лейкоцитов практически нет. В связи c этим целью настоящего обзора было суммирование данных o микровезикулах лейкоцитов. В обзоре представлены данные o клетках-источниках, внутреннем и поверхностном составе микровезикул лейкоцитов, их взаимодействии с различными клетками организма, вовлеченности в физиологические и патологические процессы. Дальнейшее изучение микровезикул позволит уточнить их роль в норме и при патологиях, возможность использования в качестве маркеров заболеваний и переносчиков различных биологически активных молекул.

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