Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC10210.15690/vramn.v68i12.854ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИCOMPARATIVE ANALYSIS OF VASCULARIZATION DEGREE OF HEPATOCELLULAR CARCINOMA AND FOCAL NODULAR HYPERPLASIA OF THE LIVER ACCORDING TO COMPUTED TOMOGRAPHY AND MORPHOLOGICAL STUDIESСРАВНИТЕЛЬНЫЙ АНАЛИЗ СТЕПЕНИ ВАСКУЛЯРИЗАЦИИ ГЕПАТОЦЕЛЛЮЛЯРНОГО РАКА И ОЧАГОВОЙ УЗЛОВОЙ ГИПЕРПЛАЗИИ ПЕЧЕНИ ПО ДАННЫМ КОМПЬЮТЕРНО-ТОМОГРАФИЧЕСКОГО И МОРФОЛОГИЧЕСКОГО ИССЛЕДОВАНИЙTumanovaU. N.ТумановаУ. Н.
Russian Federation

clinical physician of the Department of Imaging methods of Diagnosis and Treatment of FSBI “A.V. Vishnevskii Surgery Institute”, junior research scientist of the 2nd Department of Morbid anatomy of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”. Address: 27, B. Serpukhovskaya Street, Moscow, RF, 117997; tel.: +7 (495) 237-37-64

u.n.tumanova@gmail.comKarmazanovskiiG. G.КармазановскийГ. Г.
Russian Federation

PhD, professor, Head of the Department of Imaging methods of Diagnosis and Treatment of FSBI “A.V. Vishnevskii Surgery Institute”. Address: 27, B. Serpukhovskaya Street, Moscow, RF, 117997; tel.: +7 (495) 237-37-64

karmazanovsky@ixv.ruDubovaE. A.ДубоваЕ. А.
Russian Federation

MD, senior research scientist of the 2nd Department of Morbid anatomy of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”. Address: 4, Akad. Oparin Street, Moscow, RF, 117997; tel.: +7 (495) 438-28-92

e_dubova@oparina4.ruShchegolevA. I.ЩеголевА. И.
Russian Federation

PhD, professor, Head of the 2nd Department of Morbid anatomy of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”. Address: 4, Akad. Oparin Street, Moscow, RF, 117997; tel.: +7 (495) 438-28-92

ashegolev@oparina4.ruVishnevsky Institute of Surgery, Russian Ministry of Healthcare, Moscow, Russian Federation Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perina-tology, Russian Ministry of Healthcare, Moscow, Russian FederationФГБУ «Институт хирургии им. А.В. Вишневского» Минздрава России, Москва, Российская Федерация ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Минздрава России, Москва, Российская ФедерацияVishnevsky Institute of Surgery, Russian Ministry of Healthcare, Moscow, Russian FederationФГБУ «Институт хирургии им. А.В. Вишневского» Минздрава России, Москва, Российская ФедерацияAcademician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perina-tology, Russian Ministry of Healthcare, Moscow, Russian FederationФГБУ «Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Минздрава России, Москва, Российская Федерация101220136812Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук91507082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/102

A comparative analysis of vascularization degree of hepatocellular carcinoma and focal nodular hyperplasia of the liver according to the multislice computed tomography and histological study of tissue is presented. It was established that computed tomography with bolus contrast enhancement allows to study the characteristics of blood supply of the liver and focal formations. Frequently only the use of this method helps to evaluate specific morphological structure of tumors - hepatocellular carcinoma or focal nodular hyperplasia. As an additional differential diagnostic feature is recommended to increase the density determination of tissue formation in the arterial phase computed tomography study. The maximum of vascularization by computed tomography and immunohistochemistry (with antibodies CD34) are installed in a tissue of highly differentiated hepatocellular carcinoma.

Проведен сравнительный анализ степени васкуляризации гепатоцеллюлярного рака и очаговой узловой гиперплазии печени по данным мультиспиральной компьютерной томографии и гистологического исследования ткани образований. Установлено, что использование компьютерной томографии с болюсным контрастным усилением позволяет изучить особенности кровоснабжения очаговых образований печени и часто только по данным этого исследования решить вопрос о конкретной морфологической структуре новообразования – гепатоцеллюлярный рак или очаговая узловая гиперплазия. В качестве дополнительного дифференциально-диагностического признака рекомендуется определение прироста плотности ткани образования в артериальную фазу компьютерно-томографического исследования. Максимальные значения степени васкуляризации по данным компьютерной томографии и иммуногистохимического исследования (с антителами CD34) установлены в ткани высокодифференцированного гепатоцеллюлярного рака.

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