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Background: A current etiological and pathogenic opinion about human health disturbance thereupon extreme factor effects is shown that this cause is principal mechanism of regulatory system (neuroimmunoendocrine complex) distress. In endocrine link occurs hormonal disbalance in hypothalamus-hypophysis axis, physiological interrelation disturbances in central – peripheral gland system (hypophysis-adrenal, hypophysis-thyroid) and metabolism abnormalities subsequently. Objective: Our aim was to determine the particular content of adrenocorticotropic and thyrothrophin hormone, cortisol, thyroxin and triiodthyronine features at law order staff in dependence from professional loading. Methods: It’s provided two investigation series among law order staff groups — combatants, ordinary policemen and military school students. The investigation period for all people corresponds to combat mission beginning and its finish. In blood serum an adrenocorticotropic (ACTH) and thyrothrophin (TSH) hormone, cortisol, thyroxin (Т4) and triiodthyronine (Т3) levels were determined. Results: A higher ACTH and TSH levels detected at combatants in both investigation series. A cortisol, Т4 and Т3 at combatants before military mission were least in comparative with other groups, but after mission it indexes were largest. Conclusion: Prolonged changes of endocrine secretory function that lead to hormonal disbalance can result to adaptation derangement. In connection with it in medical providing system for person that undergo extreme negative professional factors it’s necessary create a special endocrine link  with the view of organism resistance and life viability to extreme emergency factors and for prevention of pathological conditions.


About the authors

R. V. Kubasov

Northern State Medical University, Archangelsk, Russian Federation

Author for correspondence.
Email: romanas2001@gmail.com
кандидат биологических наук, доцент кафедры мобилизационной подготовки здравоохранения и медицины катастроф СГМУ Адрес: 163061, Архангельск, Троицкий пр-т, д. 51, тел.: +7 (8182) 24-22-65 Russian Federation

Yu. E. Barachevskii

Northern State Medical University, Archangelsk, Russian Federation

Email: barje1@yandex.ru
доктор медицинских наук, доцент, заведующий кафедрой мобилизационной подготовки здравоохранения и медицины катастроф СГМУ Адрес: 163061, Архангельск, Троицкий пр-т, д. 51, тел.: +7 (8182) 24-22-65 Russian Federation

A. M. Ivanov

Kirov Military Medical Academy, Saint-Petersburg, Russian Federation

Email: iamvma@mail.ru
доктор медицинских наук, профессор, начальник кафедры клинической биохимии и лабораторной диагностики Военно-медицинской академии им. С.М. Кирова; главный лаборант Министерства обороны РФ Адрес: 194044, Санкт-Петербург, Пироговская наб., д. 1., тел.: +7 (812) 292-32-25 Russian Federation


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