INFLAMMATION AND BRAIN AGING

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Abstract

The review covers current concepts on cell and molecular mechanisms of neuroinflammation and aging with the special focus on the regulation of cytokine-producing activity of astroglial cells and intercellular communication. The review reflects that a key component of the aging phenomenon as a result of ineffective implementation of anti-inflammatory response are processes of the dysregulated cytokine production, in particular, an increase in the secretion of proinflammatory cytokines and an imbalance in the expression of the receptors and receptor associated proteins. Interpretation of the molecular mechanisms of cell conjugating neuroinflammation and aging cells can give rise to new therapeutic strategies that are relevant to the treatment of a wide range of central nervous system diseases and the development of new experimental models of diseases of the central nervous system.

 

About the authors

A. B. Salmina

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Author for correspondence.
Email: allasalmina@mail.ru
доктор медицинских наук, профессор, заведующая кафедрой биохимии с курсами медицинской, фармацевтической и токсикологической химии, проректор по инновационному развитию и международной деятельности КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69 Russian Federation

Yu. K. Komleva

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: yuliakomleva@mail.ru
кандидат медицинских наук, ассистент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69 Russian Federation

N. V. Kuvacheva

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: natalya.kuvacheva@gmail.ru
кандидат фармацевтических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69 Russian Federation

O. L. Lopatina

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: ol.lopatina@gmail.com
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

E. A. Pozhilenkova

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: elena.a.pozhilenkova@gmail.com
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28 Russian Federation

Ya. V. Gorina

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: yana_20@bk.ru
кандидат фармацевтических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28 Russian Federation

E. D. Gasymly

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: elya_qasimli@mail.ru
клинический ординатор кафедры нервных болезней, традиционной медицины с курсом последипломного образования КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28 Russian Federation

Yu. A. Panina

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: elving-girl@list.ru
аспирант кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28 Russian Federation

A. V. Morgun

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: 441682@mail.ru
кандидат медицинских наук, ассистент кафедры педиатрии ИПО КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28 Russian Federation

N. A. Malinovskaya

V.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian Federation

Email: konsuelo81@mail.ru

доктор медицинских наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии КрасГМУ им. В.Ф. Войно-Ясенецкого
Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

Russian Federation

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