Postgenomic Medicine: Alternative to Biomarkers

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Abstract

In the article relevance of high-performance postgenomic technologies is tackled. The intrinsic problems of the implementation of genomics, proteomics and metabolomics in routine clinical practice are considered. Further development of postgenomic medicine requires severe change in the current research approaches. Avenue for development of such approaches are illustrated by metabolome research of human blood plasma. The postgenomic biomarkers are pictured as molecular iceberg, greater part of which is inaccessible for detection with measurement methods. Due to diversity of protein forms the spectrum of molecular markers will always evaluate in terms of incompleteness and inconsistence regardless of technological development level. These properties of «big data» are typical of data intensive domains. Special computational methods are essential for data intensive analytics and hardly suitable for the evidence-based medicine.

About the authors

A. V. Lisitsa

Orekhovich Institute of Biomedical Chemistry,
Moscow

Author for correspondence.
Email: lisitsa063@gmail.com

Доктор биологических наук, член-корреспондент РАН, директор 

Адрес: 119121, Москва, ул. Погодинская, д. 10

Russian Federation

E. A. Ponomarenko

Orekhovich Institute of Biomedical Chemistry,
Moscow

Email: 2463731@gmail.com

Кандидат биологических наук, заведующая лабораторией анализа постгеномных данных

Адрес: 119121, Москва, ул. Погодинская, д. 10

Russian Federation

P. G. Lokhov

Orekhovich Institute of Biomedical Chemistry,
Moscow

Email: lokhovpg@gmail.com

Доктор биологических наук, заведующий лабораторией масс-спектрометрической метаболомной диагностики

Адрес: 119121, Москва, ул. Погодинская, д. 10, стр. 8

Russian Federation

A. I. Archakov

Orekhovich Institute of Biomedical Chemistry,
Moscow

Email: archak@ibmc.msk.ru

Доктор биологических наук, академик РАН, профессор, научный руководитель 

Адрес: 119121, Москва, ул. Погодинская, д. 10, стр. 8

Russian Federation

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