THE AIRWAYS MICROBIAL COMMUNITY COMPOSITION IN HEALTHY INDIVIDUALS AND BRONCHIAL ASTHMA PATIENTS

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Abstract

This review summarizes the results of studies on the composition of microbial communities in the airways of healthy individuals and patients with asthma. Modern molecular genetic technology of the microbial identification, which are based on a sequence determination of encoding proteins genes conserved regions. These regions form the 16s-subunit ribosomal RNA in microorganisms of different species. These genes are detected by sequencing markers characteristic of individual microorganisms and their phylogenetic groups, and allow to perform a deep analysis of the microbiota in healthy volunteers and patients with chronic bronchoobstructive diseases. So, apparently healthy human bronchial tree is characterized by low bacterial contamination (most typical representatives here are the genera Pseudomonas, Streptococcus, Prevotella, Fusobacteria and Veilonella, much less potentially pathogenic Haemophilus and Neisseria are represented). In bronchial asthma patients the lower respiratory tract microbiota undergoes a qualitative transformation: as compared to healthy individuals the number of Proteobacteria increases and the number of Bacteroidetes decreases. Severe asthma in children is associated with significant respiratory tract Staphylococcus spp. insemination. Association between the asthma developing higher risk in young children and organisms such as Haemophilus, Moraxella and Neisseria spp. It is of considerable interest to determine the role of the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the development of resistance to therapy.

About the authors

S. V. Fedosenko

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: s-fedosenko@mail.ru

кандидат медицинских наук, докторант кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины ГБОУ ВПО «СибГМУ» МЗ РФ
Адрес: 634050, Томск, Московский тракт, д. 2, тел.: (3822) 51-49-67

Russian Federation

L. M. Ogorodova

Siberian State Medical University, Tomsk, Russian Federation

Email: lm-ogorodova@mail.ru

доктор медицинских наук, профессор, член-корреспондент РАМН, заведующая кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «СибГМУ» МЗ РФ, заместитель министра науки и образования Российской Федерации
Адрес: 634050, Томск, Московский тракт, д. 2, тел.: (3822) 51-49-67

Russian Federation

M. A. Karnaushkina

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation

Email: kar3745@yandex.ru

кандидат медицинских наук, ассистент кафедры пульмонологии ФПДО ГБОУ ВПО «МГМСУ им. А.И. Евдокимова» МЗ РФ
Адрес: 127473, Москва, ул. Делегатская, д. 20, стр. 1, тел.: (495) 681-57-69

Russian Federation

E. S. Kulikov

Siberian State Medical University, Tomsk, Russian Federation

Email: evgeny.s.kulikov@gmail.com

кандидат медицинских наук, докторант кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины ГБОУ ВПО «СибГМУ» МЗ РФ
Адрес: 634050, Томск, Московский тракт, д. 2, тел.: (3822) 51-49-67

Russian Federation

I. A. Deev

Siberian State Medical University, Tomsk, Russian Federation

Email: ivandeyev@yandex.ru

доктор медицинских наук, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «СибГМУ» МЗ РФ, Первый заместитель начальника Департамента здравоохранения Томской области
Адрес: 634050, Томск, Московский тракт, д. 2, тел.: (3822) 51-49-67

Russian Federation

N. A. Kirillova

Siberian State Medical University, Tomsk, Russian Federation

Email: kirillova.natalya@gmail.com

кандидат медицинских наук, ассистент кафедры общей врачебной практики и поликлинической терапии ФПК и ППС ГБОУ ВПО «СибГМУ» МЗ РФ
Адрес: 634050, Томск, Московский тракт, д. 2, тел.: (3822) 51-49-67

Russian Federation

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