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Species of the genus Acinetobacter represent opportunistic bacteria with a growing clinical significance. In this literature review, we focus on the current role of Acinetobacter in infectious pathology and describe physiology, taxonomy, ecology, pathogenicity, and antibiotic resistance of these bacteria. Molecular pathogenesis and regulation of virulence factors in Acinetobacter spp. are described in detail. The majority of acinetobacterial infections are associated with A. baumannii and occur predominantly in an immunocompromised host. Usually, acinetobacterial infections are characterized by local purulent inflammation; in severe cases, meningitis and sepsis may develop. Antibiotic resistance of Acinetobacter is a major clinical problem; therefore we give special attention to laboratory testing of resistance as well as identification of Acinetobacter. In addition, treatment and prophylaxis of acinetobacterial infections are discussed.

About the authors

I. V. Chebotar'

Scientific Centre of Children Health, Moscow, Russian Federation

Author for correspondence.
доктор медицинских наук, ведущий научный сотрудник лаборатории микробиологии Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-53-87 Russian Federation

A. V. Lazareva

Scientific Centre of Children Health, Moscow, Russian Federation

кандидат медицинских наук, заведующая лабораторией микробиологии Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-53-87 Russian Federation

Ya. K. Masalov

Engelhardt Institute of Molecular Biology, Moscow, Russian Federation

аспирант лаборатории биологических микрочипов ФГБУН «ИМБ им. В.А. Эн- гельгардта» РАН Адрес: 119991, Москва, ул. Вавилова, д. 32, тел.: +7 (499) 135-98-46 Russian Federation

V. M. Mikhailovich

Engelhardt Institute of Molecular Biology, Moscow, Russian Federation

доктор биологических наук, ведущий научный сотрудник лаборатории биологи- ческих микрочипов ФГБУН «ИМБ им. В.А. Энгельгардта» РАН Адрес: 119991, Москва, ул. Вавилова, д. 32, тел.: +7 (499) 135-11-77 Russian Federation

N. A. Mayanskii

Scientific Centre of Children Health, Moscow, Russian Federation

доктор медицинских наук, заведующий лабораторным отделом Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-02-18 Russian Federation


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