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HYPERGLYCEMIA IMPACT ON ANGIOGENIC PROPERTIES OF ENDOTHELIAL AND PROGENITOR VASCULAR CELLS
- Authors: Parfenova Е.V.1, Tkachuk V.A.2
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Affiliations:
- FSBI Russian cardiologic scientific productive complex Ministry of Healthcare and Social development of Russian Federation, Moscow
- Lomonosov Moscow State University
- Issue: Vol 67, No 1 (2012)
- Pages: 38-44
- Section: SHORT MESSAGES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/354
- DOI: https://doi.org/10.15690/vramn.v67i1.108
- ID: 354
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Abstract
circulating progenitor cells, which define their participation in angiogenesis. Obtained data shows that cultivation of endothelial cells in hyperglycemic
conditions leads to decrease of their ability for targeted migration and vascular-like structures formation on matrigel, and to suppression of VEGF
receptors expression in these cells. Mesenchymal stem cells cultivated in hyperglycemic conditions have altered expression profile, decreased ability
to stimulate angiogenesis via paracrine activity. Hyperglycemia in CHD patients with concomitant diabetes mellitus type II most probably lead to
circulating bone marrow progenitor cells mobilisation distortion in response to tissue ischemia and damage to the endothelium, that can infringe upon
their participation in endothelium reparation and angio- and vasculogenesis in the ischemic conditions. Found distortions can be used as targets for the treatment aimed at cardiovascular complications prevention in diabetic patients.
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About the authors
Е. V. Parfenova
FSBI Russian cardiologic scientific productive complex Ministry of Healthcareand Social development of Russian Federation, Moscow
Author for correspondence.
Email: yeparfyon@mail.ru
доктор медицинских наук, профессор, руководитель лаборатории ангиогенеза ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России Адрес: 121552, Москва, ул. 3-я Черепковская, 15-а Тел.: +7(495)414-67-12 Russian Federation
V. A. Tkachuk
Lomonosov Moscow State University
Email: tkachuk@fbm.msu.ru
доктор биологических наук, профессор, академик РАН и РАМН, декан ГУНУ факуль- тета фундаментальной медицины Московского государственного университета им. М.В. Ломоносова Адрес: 119192, Москва, Ломоносовский пр., 31, корп. 5 Тел.: +7(495)932-88-14 Russian Federation
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