VEGF IN NEOPLASTIC ANGIOGENESIS

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Abstract

Solid tumor progression largely depends on vascularization and angiogenesis in the malignant tissue. The most prominent among all proangiogenic factors is vascular endothelium growth factor (VEGF). VEGF suppression leads to retrogression of neoplastic vessels and tumor growth restriction. Clinical trials of complex antiangiogenic and chemical therapy of different neoplastic tumors have shown promising results. Nowadays bevacizumab is widely used in breast cancer, colorectal cancer and II-IV stage of malignancy gliomas treatment. Unfortunately, in the majority of cases antiangiogenic treatment led not to full recovery, but only to tumor development restriction. Resistance mechanisms include potentiating of alternative proangiogenic signaling pathways and activation of malignant cell invasive population.

About the authors

V. P. Chekhonin

FSI «Serbsky State scientific centre of social and forensic psychiatry»
Ministry of Healthcare and Social development, Moscow
Pirogov Russian National scientific medical university, Ministry of Healthcare and Social Development of Russia, Moscow

Author for correspondence.
Email: chekhoninnew@yandex.ru
доктор медицинских наук, профессор, академик РАМН, заведующий Отделом фундаментальной и прикладной нейробиологии ФГУССП, заведующий кафедрой медицинских нанобиотехно- логий РГМУ Адрес: 119034, Москва, пер. Кропоткинский, д. 23 Тел.: (495) 695-02-62, факс: (495) 636-50-55 Russian Federation

S. A. Shein

Pirogov Russian National scientific medical
university, Ministry of Healthcare and Social Development of Russia, Moscow

Email: atomos@rambler.ru
аспирант кафедры медицинских нанобиотехнологий Адрес: 119634, Москва, ул. Лукинская, д. 11, кв. 191 Тел.: (916) 108-35-09 Russian Federation

A. A. Korchagina

Pirogov Russian National scientific medical
university, Ministry of Healthcare and Social Development of Russia, Moscow

Email: avilis1@yandex.ru
аспирант кафедры медицинских нанобиотехнологий Адрес: 121601, Москва, Филевский бульвар, д. 11, кв. 84 Тел.: (910) 433-17-76 Russian Federation

O. I. Gurina

FSI «Serbsky State scientific centre of social and forensic psychiatry»
Ministry of Healthcare and Social development, Moscow

Email: olga672@yandex.ru
доктор медицинских наук, руководитель лаборатории нейрохимии ФГУССП Адрес: 117587, Москва, Варшавское шоссе, д. 114/1, кв. 364 Тел.: (495) 695-02-62 Russian Federation

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