INTRAHEPATIC INDUCTION OF ENDOGENOUS S-ADENOSYL-L-METHIONINE AGAINST THE BACKGROUND OF VARIOUS WAYS OF ADMINISTRATION OF METHIONINE-SUCCINATE COMPLEX AND ITS ROLE IN DRUG-INDUCED LIVER LESION CORRECTION

Cover Page

Abstract


A comparative study of the level of endogenous S-adenosyl-L-methionine (SAM) with other hepatoprotectors in pharmacological correction of liver drug lesion. Among 117 male rats. It has been shown that among antituberculous drugs only Remaxol and Runihol were causing significant increase in endogenic SAM. Taking into account the amelioration of lab results as well as histological condition of the liver against the background of Remaxol treatment as well as positive effect of Runihol treatment upon cholestasis, one can draw a conclusion  upon the importance of succinic acid together with SAM induction as a part of hepatoprotective effect of the drug.  Reamberin, which contains succinic acid without methionine also shows hepatoprotective qualities and doesn’t induce endogenous SAM production. Positive therapeutic effect of exogenous SAM regardless the way of administration doesn’t correlate with endogenous SAM induction, and is associated with the external hepatocyte cell membrane restoration.    

 


About the authors

D. S. Sukhanov

State Budgetary Educational Institution of Higher Professional Education Mechnikov North-Western state medical university

Author for correspondence.
Email: dmitriysukhanovl@mail.ru

Russian Federation кандидат медицинских наук, доцент кафедры фтизиопульмонологии и торакальной хирургии Северо-Западного государственного медицинского университета им. И.И. Мечникова Адрес: 191015, Санкт-Петербург, ул. Кирочная, д. 41 Тел.: (953) 353-84-39, (812) 710-82-25 доб. 461

A. Yu. Petrov

JSC «Polysan», Saint-Petersburg

Email: dmitriysukhanovl@mail.ru

Russian Federation кандидат фармацевтических наук, начальник производственной лаборатории ООО «НТФФ «ПОЛИСАН» Адрес: 191119, Санкт-Петербург, Лиговский пр., д. 112

A. L. Kovalenko

JSC «Polysan», Saint-Petersburg

Email: dmitriysukhanovl@mail.ru

Russian Federation доктор биологических наук, директор по науке ООО «НТФФ «ПОЛИСАН» Адрес: 191119, Санкт-Петербург, Лиговский пр., д. 112

M. G. Romantsov

State Budgetary Educational Institution of Higher Professional Education Mechnikov North-Western state medical university

Email: dmitriysukhanovl@mail.ru

Russian Federation доктор медицинских наук, профессор кафедры инфекционных болезней Северо- Западного государственного медицинского университета им. И.И. Мечникова Адрес: 191015, Санкт-Петербург, ул. Кирочная, д. 41

References

  1. Rei`zis A.R., BorzaLova S.N., ALsenova V.A. Gepatit, indutcirovanny`i` tuberLulostatichesLimi preparatami. Rossii`skie meditcinskie vesti. 2011; XVI (1): 32–38.
  2. Nechaev V.V., Ivanov A.K., Panteleev A.M. Sotcial`no-znachimy`e infeLtcii. Chast` II. Sankt-Peterburg: ООО «Beresta». 2011. 440 s.
  3. Radchenko V.G., Shabrov A.V., Zinov`eva E.N. Osnovy` clinichesLoi` gepatologii. SPb.: NevsLii` dialeLt. 2005. 528 s.
  4. Kozhoka T.G. Lekarstvenny`e sredstva v farmaLoterapii patologii cletLi. Mosqva. 2007. 136.
  5. Okovity`i` S.V., Bezborodkina N.N., Ulei`chik S.G., Shulenin S.N. Gepatoprotektory`. M.: GE`OTAR-Media. 2010. 112.
  6. Gubergritc N.B. Ademetionin: ot farmaLologii k clinicheskoi` e`ffektivnosti. Suchasna gastroenterologіia. 2004; 18 (4): 74–82.
  7. Chishty M., Reichel A., Abbott N.J. et al. S-adenosylmethionine is substrate for carrier mediated transport at the blood-brain barrier in vitro. Brain Research. 2002; 942 (6): 46–50.
  8. Bontemps F., van Den Berghe G. Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake. Biochem. J. 1997; 327: 383–389.
  9. Hazanov V.A. FarmaLologichesLaia reguliatciia e`nergetichesLogo obmena. E`Lsperimental`naia i clinichesLaia farmaLologiia. 2009; 72(4): 61–64.
  10. Mato J.M., Martinez-Chantar M.L., Lu S.C. Methionine metabolism and liver disease 2008. Annu Rev. Nutr. 2008; 28 (5): 273–293.
  11. Winogradova T.I., Suhanov D.S., Zabolotny`kh N.V. i soavt. Sravnitel`naia ocenka vliianiia RemaLsola i ademetionina na reparativno-regeneratorny`e protcessy` pecheni v usloviiakh hirurgichesLogo vmeshatel`stva v e`Lsperimente. E`Lsperimental`naia i clinichesLaia farmaLologiia. 2011; 74 (2): 34–39.
  12. Correa P.R., Kruglov E.A., Thompson M. et al. Succinate is a paracrine signal for liver damage. Journal of Hepatology. 200 7; 47 (2): 262–269.

Statistics

Views

Abstract - 315

PDF (Russian) - 299

Cited-By


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

PlumX

Dimensions



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies