MOLECULAR MECHANISMS OF DEVELOPMENT OF CEREBRAL TOLERANCE TO ISCHEMIA (REVIEW. PART 2)

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Abstract


In the 2nd part the authors describe in details the main aspects of protective effect of preconditioning of the brain: inhibition of programmed cell death, weakening of phenomenon of excitotoxicity, activation of endogenous antioxidant systems, anti-inflammatory effects, modulation of glial cell function, changes in regional blood flow and vascular reactivity. In addition, data analysis on the impact of preconditioning on brain neurogenesis, the state of the blood-brain barrier, ion homeostasis and metabolism of neurons is presented. Review emphasizes the role of microRNAs in mechanisms of ischemic tolerance of brain. Profound understanding of molecular mechanisms of increased tolerance of brain to ischemic and reperfusion injury requires the implementation of this phenomenon in clinical practice.

 


About the authors

E. V. Shlyakhto

Saint-Petersburg State Medical Pavlov’s University, Saint-Petersburg
Saint-Petersburg, Almazov Federal Heart, Blood and Endocrinology Centre

Author for correspondence.
Email: Shlyakhto@inbox.ru

Russian Federation доктор медицинских наук, профессор, академик РАМН, директор ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития России, заведу- ющий кафедрой факультетской терапии СПбГМУ им. акад. И.П. Павлова Адрес: 197341, Санкт-Петербург, ул. Аккуратова, д. 2 Тел.: (812) 702-37-00

E. R. Barantsevich

Saint-Petersburg State Medical Pavlov’s University, Saint-Petersburg
Saint-Petersburg, Almazov Federal Heart, Blood and Endocrinology Centre

Email: profossrerb@yandex.ru

Russian Federation доктор медицинских наук, профессор, заведующий кафедрой неврологии и ману- альной медицины ФПО СПбГМУ им. акад. И.П. Павлова, заведующий НИО ангионеврологии ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития России Адрес: 197022, Санкт-Петербург, ул. Л. Толстого, д. 6/8 Тел/факс: (812) 233-45-26

N. S. Shcherbak

Saint-Petersburg State Medical Pavlov’s University, Saint-Petersburg
Saint-Petersburg, Almazov Federal Heart, Blood and Endocrinology Centre

Email: shcherbakns@yandex.ru

Russian Federation кандидат биологических наук, старший научный сотрудник лаборатории неот- ложной кардиологии Института сердечно-сосудистых заболеваний СПбГМУ им. акад. И.П. Павлова, ведущий научный сотрудник лаборатории нанотехнологий ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития России Адрес: 197341, Санкт-Петербург, ул. Аккуратова, д. 2 Тел.: (812) 702-37-00

M. M. Galagudza

Saint-Petersburg State Medical Pavlov’s University, Saint-Petersburg
Saint-Petersburg, Almazov Federal Heart, Blood and Endocrinology Centre

Email: galagoudza@mail.ru

Russian Federation доктор медицинских наук, руководитель Института экспериментальной медицины ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития России, профессор кафедры патофизиологии СПбГМУ им. акад. И.П. Павлова Адрес: 197022, Санкт-Петербург, ул. Л. Толстого, д. 6/8

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