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In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels - from peripheral neuron to central structures – that provides pain perception and painful behaviour development.


About the authors

N. N. Yakhno

The first Moscow state medical university

Author for correspondence.
доктор медицинских наук, профессор, академик РАМН, заведующий кафедрой нервных болезней Первого Московского государственного медицинского университета имени И.М. Сеченова Адрес: 119021, Москва, ул. Россолимо, д. 11 Тел.: (499) 248-65-38 Russian Federation

M. L. Kukushkin

Scientific research institute of the general pathology and pathophysiology

доктор медицинских наук, профессор, заведующий лабораторией фундаментальных и прикладных проблем боли ФГБУ НИИ общей патологии и патофизиологии РАМН Адрес: 125315, Москва, ул. Балтийская, д. 8 Тел.: (495) 601-24-20; (916) 803-79-16 Russian Federation


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