CHRONIC PAIN: MEDICO-BIOLOGIC AND SOTSIO-ECONOMIC ASPECTS

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Abstract

In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels - from peripheral neuron to central structures – that provides pain perception and painful behaviour development.

 

About the authors

N. N. Yakhno

The first Moscow state medical university

Author for correspondence.
Email: yahno@mma.ru
доктор медицинских наук, профессор, академик РАМН, заведующий кафедрой нервных болезней Первого Московского государственного медицинского университета имени И.М. Сеченова Адрес: 119021, Москва, ул. Россолимо, д. 11 Тел.: (499) 248-65-38 Russian Federation

M. L. Kukushkin

Scientific research institute of the general pathology and pathophysiology

Email: mkuk57@gmail.com
доктор медицинских наук, профессор, заведующий лабораторией фундаментальных и прикладных проблем боли ФГБУ НИИ общей патологии и патофизиологии РАМН Адрес: 125315, Москва, ул. Балтийская, д. 8 Тел.: (495) 601-24-20; (916) 803-79-16 Russian Federation

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