THE FUNDAMENTS OF NEURONAL PLASTICITY

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Abstract


 Plasticity of the nervous system  is determined by the modification of efficacy of synaptic transmission: long- term potentiation and long- term depression. Different modern technical approaches such as: registration of ionic currents in single neuron, molecular- genetic analysis, neurovisualization, and others reveal the molecular mechanisms of synaptic plasticity. The understanding of these mechanisms, in its turn, stimulates the development of methods of pharmacological correction of different forms of brain pathology such as Alzheimer disease, parkinsonism,  alcoholism, aging and others.      

 


About the authors

V. G. Skrebitskii

Research Center of Neurology Russian Academy of medical Science, Moscow
Institute of Molecular Biology and Biophysics Siberian Division of RAMS, Novosibirsk

Author for correspondence.
Email: skrebitsky@yahoo.com

Russian Federation доктор биологических наук, профессор, член-корр. РАН и РАМН, заведующий лабораторией функциональной синаптологии отдела исследований мозга ФГБУ «НЦН» РАМН Адрес: 125319, Москва, ул. Черняховского, д. 4/7 Тел./факс: (495) 917-23-82

M. B. Shtark

Research Center of Neurology Russian Academy of medical Science, Moscow
Institute of Molecular Biology and Biophysics Siberian Division of RAMS, Novosibirsk

Email: mark@soramn.ru

Russian Federation доктор биологических наук , профессор, академик РАМН, руководитель отдела физики и биоинженерии Института молекулярной биологии и биофизики Адрес: 630117, Новосибирск, ул. Тимакова, д. 2 Тел./факс: (383)335-98-47

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