MECHANISMS OF CEREBRAL DAMAGE IN PATIENTS WITH HIV-INFECTION

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Abstract

Mechanisms of HIV transportation through blood-brain barrier, vascular plexus and interaction with cerebral cells having CD-4-receptors, ССR-5- and CXCR-4-coreceptors were studied. Cerebral damage developed through latent and acute periods also known as HIV-encephalopathy, HIV-associated neurocognitive dysfunction etc. Cerebral lesions are caused by a variety of chemical agents from pro-inflammatory cytokines to toxic HIV-proteins resulting in development of HIV-dementia through several years. Even early stage of this process revealed significant disturbances of glucose metabolism and evoked potentials EEG alterations which can serve as a marker of HIV-infection. Genetic differences of HIV in blood and spinal liquor with different drug resistance were revealed implying a new approach to therapy development.

 

About the authors

N. A. Belyakov

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Author for correspondence.
Email: aidscentr@zdrav.spb.ru
доктор медицинских наук, академик РАМН, руководитель Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, главный научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53 Russian Federation

S. V. Medvedeva

N.P. Bechterev Institute of Human Brain, St. Petersburg

Email: aidscentr@zdrav.spb.ru
доктор биологических наук, член-корреспондент РАН, директор Института мозга человека РАН, Санкт-Петербург Адрес: 193376, Санкт-Петербург, ул. Акад. Павлова, д. 9 Тел.: (812) 234-32-47 Russian Federation

T. N. Trofimova

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: Ras-doc@mail.ru
доктор медицинских наук, профессор, главный научный сотрудник Института мозга человека РАН, главный научный сотрудник НИИ экспериментальной медицины СЗО РАМН, профессор- консультант Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53 Russian Federation

V. V. Rassokhin

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: aidscentr@zdrav.spb.ru
кандидат медицинских наук, заместитель руководителя Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, ведущий научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53 Russian Federation

N. E. Dement'eva

St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: lab.dementeva@mail.ru
врач-генетик Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53 Russian Federation

S. A. Shelomov

St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: aidscentr@zdrav.spb.ru
врач-инфекционист Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-0853 Russian Federation

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