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INTRACELLULAR TARGETS OF PROAPOPTOTIC INFLUENCE OF GASEOUS TRANSMITTERS
- Authors: Tashireva L.A.1, Starikova E.G.1, Novitskii V.V.1, Ryazantseva N.V.1
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Affiliations:
- Siberian State Medical University, Tomsk
- Issue: Vol 67, No 10 (2012)
- Pages: 77-81
- Section: SHORT MESSAGES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/260
- DOI: https://doi.org/10.15690/vramn.v67i10.420
- ID: 260
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Abstract
Main molecular targets of nitric oxide, hydrogen sulfide and carbon monoxide proapoptotic action in Jurkat cells were determined in this study. Decrease of mitochondrial transmembrane potential was shown during all three gases action. Reason of this event is the Bcl-2 family members disbalance. Proapoptotic proteins release after mitochondrion membranes permeabilisation could be abolished by protein xIAP inhibition of caspase -9 and-3 activity during NO and CO application.
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About the authors
L. A. Tashireva
Siberian State Medical University, Tomsk
Author for correspondence.
Email: lkleptsova@mail.ru
аспирант кафедры патофизиологии ГБОУ ВПО СибГМУ МЗ РФ Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 66-30-50 Russian Federation
E. G. Starikova
Siberian State Medical University, Tomsk
Email: to-elen@yandex.ru
кандидат медицинских наук, докторант кафедры патофизиологии ГБОУ ВПО СибГМУ МЗ РФ Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 24-37-81 Russian Federation
V. V. Novitskii
Siberian State Medical University, Tomsk
Email: office@ssmu.ru
академик РАМН, профессор, заведующий кафедрой патофизиологии ГБОУ ВПО СибГМУ МЗ РФ Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 53-04-23 Russian Federation
N. V. Ryazantseva
Siberian State Medical University, Tomsk
Email: strateg@ssmu.ru
доктор медицинских наук, профессор, заведующая кафедрой фундаментальных основ клинической медицины ГБОУ ВПО СибГМУ МЗ РФ Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 52-77-47 Russian Federation
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