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This review presents detailed analysis of scientific data on influence of the associated with interleukin-1 cytokines on the development of malignant tumors of stomach with the definition of spectrum of diagnostic and therapeutic possibilities. Cytokines associated with interleukin-1 directly and indirectly involved into gastric carcinogenesis. Implementation of pro- and contreoncogenic effects depends on many factors. The serological and genetic criteria changes of interleukin-1 have high diagnostic value and prognostic significance opening new differential approaches to the treatment of precancer conditions and gastric cancer.


About the authors

L. V. Matveeva

Medical Institute of N.P. Ogarev Mordovian State University, Saransk, Russian Federation

Author for correspondence.
кандидат медицинских наук, доцент кафедры иммунологии, микробиологии и виру- сологии медицинского института МГУ им. Н.П. Огарева Адрес: 430032, Республика Мордовия, г. Саранск, ул. Ульянова, д. 26а Тел.: (8342) 35-25-16 Russian Federation

L. M. Mosina

Medical Institute of N.P. Ogarev Mordovian State University, Saransk, Russian Federation

доктор медицинских наук, профессор кафедры госпитальной терапии медицинского института МГУ им. Н.П. Огарева Адрес: 430032, Республика Мордовия, Саранск, ул. Ульянова, д. 26а Тел.: (8342) 32-19-83 Russian Federation


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