The Influence of Obesity and Sedentary Lifestyle on Testosterone Level and the Main Indicators of the Metabolic Status in Young Men

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Background. It is considered an established fact that there is an adverse trend in the male reproductive potential, which has been observed in various countries over the past decades. It is assumed that it can be formed due to the influence of individual lifestyle factors, in particular, a decrease in the level of physical activity and excessive nutrition, leading to obesity. However, the effect of obesity combined with sedentary or physically active lifestyle on the reproductive hormone level and metabolic homeostasis has not been studied well.

Aims — the aim of the work was to study the effects of obesity combined with sedentary or active physical lifestyle on the level of reproductive hormones and the main indicators of metabolic status of young men.

Methods. In young male volunteers (median age — 23 years, n = 295) from the general population, anthropometry was performed, which included body height and weight, waist and hip circumference, and body mass index (BMI); and they were also asked to fill out a questionnaire containing questions about individual lifestyle. In addition, serum concentrations of follicle stimulating and luteinizing hormones, testosterone, estradiol, inhibin B and triglycerides, total cholesterol, high and low density lipoprotein cholesterol, glucose, uric acid were evaluated.

Results. The most important lipid metabolism disorders observed in overweight and obesity included an increase in triglycerides, total cholesterol, low-density lipoprotein cholesterol and a decrease in high-density lipoprotein cholesterol. Overweight and obesity in men was accompanied by an increase in waist and hip circumference, a decrease in the serum level of testosterone and inhibin B reaching in obese men the testosterone values characteristic for hypogonadism. Sedentary obese men had the increased waist circumference, lower testosterone level (median — 13.6 vs. 18.0 nmol/L), elevated glucose level (median — 5.8 vs. 4.9 mmol/L) compared to physically active obese men or those who prefer sports or physical recreation.

Conclusions. In men, obesity negatively affects the serum level of testosterone and glucose, increases the accumulation of visceral fat, but a physically active lifestyle and sports give significant advantages to obese men, as it contributes to an increase in testosterone levels and normalization of metabolic parameters.

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About the authors

Ludmila V. Osadchuk

The Federal Research Center Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Author for correspondence.
ORCID iD: 0000-0002-7597-9204
SPIN-code: 2924-3468
Scopus Author ID: 7004923596

PhD in Biology, Professor

Russian Federation, 10, Lavrentiev Av., 630090, Novosibirsk

Alexander V. Osadchuk

The Federal Research Center Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID iD: 0000-0002-4210-7354
SPIN-code: 4023-5070
Scopus Author ID: 7004220731

PhD in Biology, Assistant Professor

Russian Federation, 10, Lavrentiev Av., 630090, Novosibirsk


  1. Аполихин О.И., Москалева Н.Г., Комарова В.А. Современная демографическая ситуация и проблемы улучшения репродуктивного здоровья населения России // Экспериментальная и клиническая урология. — 2015. — № 4. — С. 4–14. [Apolikhin OI, Moskaleva NG, Komarova VA. Contemporary demographic situation and problems of improving the reproductive health of Russian population. Experimental and Clinical Urology. 2015;4:4–14. (In Russ.)]
  2. Лебедев Г.С., Голубев Н.А., Шадеркин И.А., и др. Мужское бесплодие в Российской Федерации: статистические данные за 2000–2018 годы // Экспериментальная и клиническая урология. — 2019. — № 4. — С. 4–12. [Lebedev GS, Golubev NA, Shaderkin IA, et al. Male infertility in the Russian Federation: statistical data for 2000–2018. Experimental and Clinical Urology. 2019;4:4–12. (In Russ.)] doi:
  3. Осадчук Л.В., Осадчук А.В. Популяционные исследования мужского репродуктивного потенциала: качество сперматозоидов как маркер репродуктивного здоровья // Урология. — 2020. — № 3. — С. 111–120. [Osadchuk LV, Osadchuk AV. Epidemiological studies of the male reproductive potential: sperm quality as a marker of reproductive health. Urologiia. 2020;3:111–120. (In Russ.)]. doi:
  4. Osadchuk L, Shantanova L, Troev I, et al. Regional and ethnic differences in semen quality and reproductive hormone levels in Russia: a Siberian population-based cohort study of young men. Andrology. 2021;9(5):1512–1525. doi:
  5. Leisegang K, Dutta S. Do lifestyle practices impede male fertility? Andrologia. 2021;53(1):e13595. doi:
  6. Crovesy L, Rosado EL. Interaction between genes involved in energy intake regulation and diet in obesity. Nutrition. 2019;67–68:110547. doi:
  7. Vaamonde D, Da Silva-Grigoletto ME, García-Manso JM, et al. Physically active men show better semen parameters and hormone values than sedentary men. Eur J Appl Physiol. 2012;112(9):3267–3273. doi:
  8. Ibañez-Perez J, Santos-Zorrozua B, Lopez-Lopez E, et al. An update on the implication of physical activity on semen quality: a systematic review and meta-analysis. Arch Gynecol Obstet. 2019;299(4):901–921. doi:
  9. Lavín-Pérez AM, Collado-Mateo D, Villafaina S, et al. The role of exercise to reduce the impact of diabetes in the seminal quality: a systematic review. Medicina (Kaunas). 2021;57(2):159. doi:
  10. Gaskins AJ, Chavarro JE. Diet and fertility: a review. Am J Obstet Gynecol. 2018;218(4):379–389. doi:
  11. Priskorn L, Jensen TK, Bang AK, et al. Is sedentary lifestyle associated with testicular function? A cross-sectional study of 1,210 men. Am J Epidemiol. 2016;184(4):284–294. doi:
  12. Minas A, Fernandes ACC, Maciel Júnior VL, et al. Influence of physical activity on male fertility. Andrologia. 2022;54(7):e14433. doi:
  13. Kivimäki M, Strandberg T, Pentti J, et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study. Lancet Diabetes Endocrinol. 2022;10(4):253–263. doi:
  14. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.
  15. Осадчук Л.В., Попова А.В., Туманик О.В., и др. Андрогенный дефицит у мужчин с избыточной массой тела и ожирением // Проблемы репродукции. — 2012. — № 4. — С. 76–79. [Osadchuk LV, Popova AV, Tumanik OV, et al. Androgens deficiency in men with overweight and obesity. Russian Journal of Human Reproduction. 2012;4:76–79. (In Russ.)]
  16. Осадчук Л.В., Гуторова Н.В., Петрова П.Г., и др. Гормональный и метаболический статус у мужчин якутской этнической принадлежности c избыточной массой тела и ожирением // Проблемы репродукции. — 2014. — № 2. — С. 78–83. [Osadchuk LV, Gutorova NV, Petrova PG, et al. Hormonal and metabolic status in men of Yakut ethnic group with overweight and obesity. Russian Journal of Human Reproduction. 2014;2:78–83. (In Russ.)]
  17. Hasan B, Nayfeh T, Alzuabi M, et al. Weight loss and serum lipids in overweight and obese adults: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2020;105(12):dgaa673. doi:
  18. Осадчук Л.В., Гуторова Н.В., Людинина А.Ю., и др. Изменение гормонального и метаболического статуса у мужчин этнической группы коми с избыточной массой тела и ожирением // Ожирение и метаболизм. — 2013. — Т. 10. — № 2. — С. 28–32. [Osadchuk LV, Gutorova NV, Ludinina AYu, et al. Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity. Obesity and metabolism. 2013;10(2):28–32. (In Russ.)]. doi:
  19. Гуторова Н.В., Клещёв М.А., Типисова Е.В., и др. Влияние избыточной массы тела и ожирения на показатели спермограммы и уровень репродуктивных гормонов у мужского населения Европейского Севера России // Бюллетень экспериментальной биологии и медицины. — 2014. — Т. 157. — № 1. — С. 108–111. [Gutorova NV, Kleshchyov MA, Tipisova EV, et al. Effects of overweight and obesity on the spermogram values and levels of reproductive hormones in the male population of the European North of Russia. Bulletin of Experimental Biology and Medicine. 2014;157(1):95–98. (In Russ.)]
  20. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 1972;18(6):499–502.
  21. Aggerholm AS, Thulstrup AM, Toft G, et al. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril. 2008;90(3):619–626. doi:
  22. Durairajanayagam D. Lifestyle causes of male infertility. Arab J Urol. 2018;16(1):10–20. doi:
  23. Гамидов С.И., Шатылко Т.В., Гасанов Н.Г. Мужское здоровье и ожирение — диагностика и терапевтические подходы // Ожирение и метаболизм. — 2019. — Т. 16. — № 3. — С. 29–36. [Gamidov SI, Shatylko TV, Gasanov NG. Male health and obesity — diagnostic and therapeutic approach. Obesity and metabolism. 2019;16(3):29–36. (In Russ.)]. doi:
  24. Saad F, Grahl AS, Aversa A, et al. Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction. BJU Int. 2007;99(5):988–992. doi:
  25. Jensen TK, Andersson AM, Jørgensen N, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863–870. doi:
  26. Liu Y, Ding Z. Obesity, a serious etiologic factor for male subfertility in modern society. Reproduction. 2017;154(4):R123–R131. doi:
  27. Bujan L, Daudin M, Charlet JP, et al. Increase in scrotal temperature in car drivers. Hum Reprod. 2000;15(6):1355–1357. doi:
  28. Mínguez-Alarcón L, Gaskins AJ, Chiu YH, et al. Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod. 2018;33(9):1749–1756. doi:
  29. Rao M, Zhao XL, Yang J, et al. Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men. Asian J Androl. 2015;17(4):668–675. doi:
  30. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, et al. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005;20(1):208–215. doi:
  31. Kumagai H, Zempo-Miyaki A, Yoshikawa T, et al. Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone. J Clin Biochem Nutr. 2016;58(1):84–89. doi:
  32. Kraemer WJ, Ratamess NA, Hymer WC, et al. Growth hormone(s), testosterone, insulin-like growth factors, and cortisol: roles and integration for cellular development and growth with exercise. Front Endocrinol (Lausanne). 2020;11:33. doi:

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