IMMUNOPHENOTYPIC CHARACTERISTIC OF DENDRITIC CELLS IN BRONCHIAL ASTHMA IN CONDITIONS OF EXTRACT OPISTHORCHIS FELINEUS IN VITRO

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Abstract


This work shows comparative characteristics of immunogenic properties of the extract of Opisthorchis felineus in different severity of asthma using antigen presenting dendritic cells in vitro. New data on the effect of Opisthorchis felineus on the expression of surface markers of dendritic cells (CD209, HLA-DR, CD83, CD86) were received. Pronounced expression of CD209, CD86 and HLA-DR on the surface of dendritic cells in mild and severe asthma compared with healthy individuals was shown. In the stimulation of dendritic cells with extract Opisthorchis felineus in vitro weakening of CD86 expression in mild and in severe asthma was found. CD86 molecule may be a regulatory factor in the co-stimulation of dendritic cells which allows us to consider it as a potential pharmacological target for the treatment of allergic diseases.

 


About the authors

E. E. Kremer

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: elenakremer@yandex.ru

Russian Federation PhD, Research Worker, Central Research Laboratory, Siberian State Medical University Address: 634050, Tomsk, Moscovsky Trakt, 2/18; tel.: (3822) 52-83-97

L. M. Ogorodova

Siberian State Medical University, Tomsk, Russian Federation

Email: lm-ogorodova@mail.ru

Russian Federation RAMS cor. member, Professor, Head of Department of Pediatric Faculty with a Course of Children Diseases of the Medical faculty, Siberian State Medical University Address: 634050, Tomsk, Moscovsky Trakt, 2; tel.: (3822) 53-10-22

N. A. Kirillova

Siberian State Medical University, Tomsk, Russian Federation

Email: kirillova.natalya@gmail.com

Russian Federation PhD, Assistant, The Department of Hospital Therapy with Course of Physical Rehabilitations and Sports Medicine, Siberian State Medical University Address: 634063, Tomsk, street Chernykh, 96; tel.: (3822) 64-44-81

K. V. Khvorilova

Siberian State Medical University, Tomsk, Russian Federation

Email: kseniahvorilova@gmail.com

Russian Federation Junior Research Worker, Central Research Laboratory, Siberian State Medical University Address: 634050, Tomsk, Moscovsky Trakt, 2/18; tel.: (3822) 52-83-97

T. V. Perevozchikova

Siberian State Medical University, Tomsk, Russian Federation

Email: perevozchikova.tv@gmail.com

Russian Federation PhD, Research Worker, Central Research Laboratory, Siberian State Medical University. Address: 634050, Tomsk, Moscovsky Trakt, 2/18; tel.: (3822) 52-83-97

E. A. Fait

Siberian State Medical University, Tomsk, Russian Federation

Email: fa1len@mail.ru

Russian Federation Junior Research Worker, Central Research Laboratory, Siberian State Medical University Address: 634050, Tomsk, Moscovsky Trakt, 2/18; tel.: (3822) 52-83-97

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